Journal of dental hygiene science (치위생과학회지)

The Korean Society of Dental Hygiene Science (한국치위생과학회)
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Literature Review on the Incidence and Risk Factor of Oral Cancer

구강암의 발생현황과 원인

  • Published : 2012.10.31
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Abstract

The purpose of this study was to examine pervasive trends in oral cancer in different countries in an effort to discuss what to do to prevent cancer and drop a death rate. The materials of the study were selected from among articles of oral cancer by searching risk factor and epidemiology at a website (www.oraloncology.com). As a result of analyzing the selected literature, it's found that in our country, the percentage of oral cancer in total cancer dropped but the number of oral cancer patients was on the rise every year. In foreign countries, the number of oral cancer patients was on the increase as well, whereas the lethality dropped. In terms of demographic characteristics, the incidence rate of oral cancer was higher among men than women overall. The incidence rate of oral cancer was larger among older people. The major causes of oral cancer were smoking and drinking. To reduce the incidence rate of oral cancer, every possible institutional, administrative and legal measure should be taken to ensure of anti-smoking policies, and publicity of moderation in and abstinence from drinking should be reinforced. The additional causes of oral cancer were demographic characteristics by country and region. The incidence of oral cancer was under the influence of that was affected when the level of personal economy and education was low. Therefore it's important to redress social imbalance within a country and among countries to remove socioeconomic divide. As the oral cancer patients has increased every year, the incidence rate of it should accurately be grasped, and sustained research efforts should be made in consideration of demographic characteristics. Early diagnosis, public oral health education and preventive policies are all required to decrease the incidence rate of oral cancer.

기존 문헌의 조사결과 우리나라의 경우 전체 암에 대한 구강암 발생률은 감소하고 있지만 발생자수는 해마다 증가하고 있었다. 외국의 경우도 발생자수는 증가하고 있고, 반면 치사율은 낮아지고 있었다. 인구학적 특성에 따라서는 전반적으로 남자가 여자보다 구강암 발생률이 높았으며, 특히 연령이 낮을수록 남자와 여자의 발생 비율의 차이가 현저히 남자가 높았다. 구강암은 연령이 높은 집단에서 발생률이 증가하였다. 연령이 높을수록 협점막에서, 연령이 낮을수록 혀에서 다발하는 것으로 보고되었으나, 전반적으로 구내암이 가장 많이 빈발하였다. 구강암의 원인을 살펴본 많은 연구에서 담배와 음주를 구강암 발생의 원인으로 꼽았다. 특히 담배와 흡연은 구강암뿐만 아니라 기타 여러 암에 영향을 미친다. 따라서 구강암을 비롯한 여러 암발생을 감소시키기 위해 제도적, 행정적, 법적으로 적극적인 금연정책이 필요하며 더불어 절주 또는 금주에 대한 홍보가 필요할 것이다. 또한 구강암의 위험요인은 국가 및 지역별, 인구학적 특성에 따른다. 즉 태양으로부터 노출된 자외선의 양이 많을수록 입술 암이 발생하는 것과 낮은 경제적 수준과 교육수준, 힘겹게 연명하는 정도의 삶의 수준은 구강암을 발생에 영향을 주게 된다. 이외에도 비타민 및 단백질 결핍과 같은 영양결핍, 구강위생정도 및 인식과 습관 등도 구강암을 발생시킨다. 따라서 사회경제적 수준에 따른 격차가 생기지 않도록 국가 내에서, 또한 국가간의 사회적 불균형의 해소가 중요하다. 암은 점점 생존율이 높아지고 있지만 아직까지 현대 질병의 사망원인으로 큰 비중을 차지하고 있으며, 계속해서 이환된 환자가 증가하고 있다. 구강암은 기타 암 발생비율에 비해 낮아지는 수치를 보이고 있지만 발생자수가 증가하고 있어 구강암 발생 동향을 파악하고 인구학적 특성과 관련된 연구가 지속적으로 시행되어야 한다. 또한 구강암과 관련된 조직학적 연구나 현재 동향의 정보는 구강암 생존과 관련된 여러 요인을 파악하는데 도움을 주며, 구강암에 관한 계속적인 연구는 효과적인 구강건강프로그램을 개선시키고 구강보건교육과 구강암 검사프로그램을 만드는데 자료로 제공될 수 있다. 이제 암의 재발기간이 5년에서 10년으로 늘어난 만큼 암은 정복 되어야 할 질병으로 구강암 발생을 줄이기 위해서는 조기진단과 공중구강보건교육 및 예방정책이 필요하다. 따라서 정부와 관련된 단체 및 3차 진료기관 등과 협력하여 치과계 직종 종사자들은 책임감을 갖고 국민의 구강건강상태를 향상시키고 구강암 발생을 감소시키는데 노력해야 할 것이다.

Keywords

References

  1. Kwon HK, et al.: Risk factors for oral cancer; a case-control study. J Kor Oral Maxillofac Surg 28: 395-400, 2004.
  2. National Cancer Information Center. http://www.cancer.go.kr/cms/cancer/cancer_is/01/1190424_1221.html.
  3. Syjha S, et al.: Cost effectiveness of oral cancer screening: results from a cluster randomized controlled trial in India Bull World Health Organ 82: 200-206, 2009.
  4. Kim HD, et al.: Factors influencing knowledge about early signs and causes of oral cancer in Korean elders. J Korean Acad Dent Health 28: 570-582, 2004.
  5. Carlo LV, et al.: Trends in oral cancer morality in Europe. Oral Oncol 40: 433-439, 2004. https://doi.org/10.1016/j.oraloncology.2003.09.013
  6. Ostman J, et al.: Malignant oral tumours in Sweden 1960-1989-an epidemiological study. Oral Oncol, Eur J Cancer, 31B: 106-112, 1995.
  7. Robinson KL, Macfarlane GJ: Oropharyngeal cancer incidence and mortality in Scotland: are rates still increasing? Oral Oncol 39: 31-6, 2003. https://doi.org/10.1016/S1368-8375(02)00014-3
  8. Kumar V, Cotran RS, Robbins SL: Robbins basic pathology. 7th. Saunders, Philadelphia, pp.165-177, 2003.
  9. Kwon KH, et al.: Oral & maxillofacial surgery. 2nd. Daehannarae, Seoul, pp.195-201, 2008.
  10. Canto MT, Devesa SS: Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998. Oral Oncol 38: 610-617, 2002. https://doi.org/10.1016/S1368-8375(01)00109-9
  11. Maria TC, Susan SD: Oral cavity and pharynx cancer incidence rates in the United States 1995-1998. Oral Oncol 38: 610-617, 2002. https://doi.org/10.1016/S1368-8375(01)00109-9
  12. Chima O, Chukwuneke FN: Oral cancer in Enugu, Nigeria, 1998-2003. Br J Oral Maxillofac Surg 45: 298-301, 2007. https://doi.org/10.1016/j.bjoms.2006.09.001
  13. Naganuma T, et al.: Coffee consumption and the risk of oral, pharyngeal, and esophageal cancers in Japan. American Journal of Epidemiology 168:1425-1432, 2008. https://doi.org/10.1093/aje/kwn282
  14. http://www.cancer.go.kr/ncic/cics_a/01/012/index.html.
  15. Ministry of Health and Welfare: Annual report of cancer statistics in Korea in 2009, 2011. http://e-welfare.go.kr/wp/data/sta/viewSta04Info.laf?content_id=212450&path=/wfisc/wp/inf/sta/04/html&rn=3.
  16. Lee JY, Han YS: Clinical analysis of intra-oral carcinomas-473 cases-. J Korean Soc Plast Reconstr Surg 15: 469-479, 1988.
  17. Mores DE, et al.: Trends in the incidence of lip, oral, and pharyngeal cancer: connecticut, 1935-94. Oral Oncol 35: 1-8, 1999. https://doi.org/10.1016/S1368-8375(98)00071-2
  18. http://www.cancer.gov/.
  19. Antunes JLF, et al.: Trends and spatial distribution of oral cancer mortality in Sao Paulo, Brazil, 1980-1998. Oral Oncol 37: 345-350, 2001. https://doi.org/10.1016/S1368-8375(00)00113-5
  20. Victor WF: The epidemiology of oral and pharynx cancer in Brazil. Oral Oncol 38: 737-746, 2002. https://doi.org/10.1016/S1368-8375(02)00066-0
  21. Hindle I, Downer MC, Speight PM: The epidemiology of oral cancer. Br J Oral Maxillofac Surg 34: 471-476, 1996. https://doi.org/10.1016/S0266-4356(96)90111-4
  22. Rehman K, Monaghan A: Epidemiology of oral cancer in the West Midlands, UK. Oral Oncol 3: 56-122, 2009.
  23. W-Z S, et al.: Trends in site-specific mortality from oral and pharyngeal cancer among Japanese males, 1950-94. Oral Oncol 35: 9-16, 1999. https://doi.org/10.1016/S1368-8375(98)00038-4
  24. Sherin N, et al.: Changing trend in oral cancer. Indian J Cancer 45: 93-96, 2008. https://doi.org/10.4103/0019-509X.44063
  25. Kuruvilla J: Utilizing dental colleges for the eradication of oral cancer in India. Indian J Dent Res, 19: 349-353, 2008. https://doi.org/10.4103/0970-9290.44541
  26. Braakhuis JM, Visser O, ReneLeemans C: Oral and oropharyngeal cancer in The Netherlands between 1989 and 2006: increasing incidence, but not in young adults. Oral Oncol 45: 85-89, 2009. https://doi.org/10.1016/j.oraloncology.2008.02.011
  27. Visscher JGAM, et al.: Epidemiology of cancer of the lop in the Netherlands. Oral Oncol 34: 421-426, 1998. https://doi.org/10.1016/S1368-8375(98)00029-3
  28. Moreno-Lopez LA, et al.: Risk of oral cancer associated with tobacco smoking, alcohol consumption and oral hygiene: a case-control study in Madrd, Spain. Oral Oncol 36: 170-174, 2000. https://doi.org/10.1016/S1368-8375(99)00084-6
  29. Morris RE, et al.: The epidemiology of lip, oral cavity and pharyngeal cancers in Kuwait 1979-1988. Br J Oral Maxillofac Surg 38: 316-319, 2000. https://doi.org/10.1054/bjom.1999.0247
  30. McCartan BE, Cowan CG, Healy CM: Regional variations in oral cancer incidence in Ireland. Oral Oncol 41: 677-686, 2005. https://doi.org/10.1016/j.oraloncology.2005.03.010
  31. Oji C, Chukwuneke FN: Oral cancer in Enugu, Nigeria, 1998-2003. Br J Oral Maxillofac Surg 45: 298-301, 2007. https://doi.org/10.1016/j.bjoms.2006.09.001
  32. Guneri P, et al.: Primary oral cancer in a Turkish Population sample: association with sociodemographic features, smoking, alcohol, diet and dentition. Oral Oncol 41: 1005-1012, 2005. https://doi.org/10.1016/j.oraloncology.2005.06.002
  33. Toledo ALA, et al.: Dietary patterns and risk of oral and pharyngeal cancer: a case-control study in Rid de Janeiro, Brazil. (Cad.) Saude Publica, Rio de Janeiro 26: 135-142, 2010.
  34. Maria B: Etiology of oral cancer in the young patient: is tongue cancer becoming the other cancer in women? Oral Maxillofacial Surg Clin N Am 19: 163-171, 2007. https://doi.org/10.1016/j.coms.2007.01.004
  35. Bunnell A, et al.: Analysis of primary risk factors for oral cancer from select US states with increasing rates. Tob Induc Dis 8: 5, 2010. https://doi.org/10.1186/1617-9625-8-5
  36. Anthony P: Trends in incidence rates of tobacco-related cancer, selected areas, SEER program, United States, 1992-2004. Prev Chronic Dis 6: A16, 2009.
  37. Rodriguez T, et al.: Risk factors for oral and pharyngeal cancer in young adults. Oral Oncol 40: 207-213, 2004. https://doi.org/10.1016/j.oraloncology.2003.08.014
  38. Eadie D, et al.: Development and evaluation of an early detection intervention for mouth cancer using a mass media approach. Br J Cancer 101: 573-579, 2009.
  39. Bagan JV, Scully C: Recent advances in Oral Oncology 2007: epidemiology, aetiopathogenesis, diagnosis and prognostication. Oral Oncol 44: 103-108, 2008. https://doi.org/10.1016/j.oraloncology.2008.01.008
  40. Ross OC, et al.: A library-based ecological study to investigate the contribution of ethnicity to the incidence of oral cancer within health authorities in England and Wales. Br J Oral Maxillofac Surg 49: 42-46, 2010.