Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Prognostic Value of Volume-Based $^{18}F$-Fluorodeoxyglucose PET/CT Parameters in Patients with Clinically Node-Negative Oral Tongue Squamous Cell Carcinoma

  • Lee, Su Jin (Department of Nuclear Medicine, Ajou University School of Medicine) ;
  • Choi, Joon Young (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Hwan Joo (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Baek, Chung-Hwan (Department of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Son, Young-Ik (Department of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hyun, Seung Hyup (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Moon, Seung Hwan (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Byung-Tae (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Published : 2012.12.01
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Abstract

Objective: To evaluate the prognostic value of volume-based metabolic parameters measured with $^{18}F$-fluorodeoxyglucose ($^{18}F$-FDG) positron emission tomography (PET) in patients with clinically node-negative (cN0) oral tongue squamous cell carcinoma (OTSCC) as compared with other prognostic factors. Materials and Methods: In this study, we included a total of 57 patients who had been diagnosed with cN0 tongue cancer by radiologic, $^{18}F$-FDG PET/CT, and physical examinations. The maximum standardized uptake value ($SUV_{max}$), average SUV ($SUV_{avg}$), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for primary tumors were measured with $^{18}F$-FDG PET. The prognostic significances of these parameters and other clinical variables were assessed by Cox proportional hazards regression analysis. Results: In the univariate analysis, pathological node (pN) stage, American Joint Committee on Cancer (AJCC) stage, $SUV_{max}$, $SUV_{avg}$, MTV, and TLG were significant predictors for survival. On a multivariate analysis, pN stage (hazard ratio = 10.555, p = 0.049), AJCC stage (hazard ratio = 13.220, p = 0.045), and MTV (hazard ratio = 2.698, p = 0.033) were significant prognostic factors in cN0 OTSCC patients. The patients with MTV ${\geq}$ $7.78cm^{3}$ showed a worse prognosis than those with MTV < $7.78cm^{3}$ (p = 0.037). Conclusion: The MTV of primary tumor as a volumetric parameter of $^{18}F$-FDG PET, in addition to pN stage and AJCC stage, is an independent prognostic factor for survival in cN0 OTSCC.

Keywords

References

  1. Bello IO, Soini Y, Salo T. Prognostic evaluation of oral tongue cancer: means, markers and perspectives (I). Oral Oncol 2010;46:630-635 https://doi.org/10.1016/j.oraloncology.2010.06.006
  2. Bello IO, Soini Y, Salo T. Prognostic evaluation of oral tongue cancer: means, markers and perspectives (II). Oral Oncol 2010;46:636-643 https://doi.org/10.1016/j.oraloncology.2010.06.008
  3. Regezi JA, Sciubba JJ, Jordan RCK. Oral pathology: Clinical, pathologic correlations, 5th ed. St. Louis, MO: Saunders Elsevier, 2007
  4. Leipzig B, Cummings CW, Chung CT, Johnson JT, Sagerman RH. Carcinoma of the anterior tongue. Ann Otol Rhinol Laryngol 1982;91(1 Pt 1):94-97 https://doi.org/10.1177/000348948209100121
  5. Rusthoven K, Ballonoff A, Raben D, Chen C. Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. Cancer 2008;112:345-351 https://doi.org/10.1002/cncr.23183
  6. Sathyan KM, Sailasree R, Jayasurya R, Lakshminarayanan K, Abraham T, Nalinakumari KR, et al. Carcinoma of tongue and the buccal mucosa represent different biological subentities of the oral carcinoma. J Cancer Res Clin Oncol 2006;132:601-609 https://doi.org/10.1007/s00432-006-0111-y
  7. Zanation AM, Sutton DK, Couch ME, Weissler MC, Shockley WW, Shores CG. Use, accuracy, and implications for patient management of [18F]-2-fluorodeoxyglucose-positron emission/computerized tomography for head and neck tumors. Laryngoscope 2005;115:1186-1190 https://doi.org/10.1097/01.MLG.0000163763.89647.9F
  8. Fletcher JW, Djulbegovic B, Soares HP, Siegel BA, Lowe VJ, Lyman GH, et al. Recommendations on the use of 18F-FDG PET in oncology. J Nucl Med 2008;49:480-508 https://doi.org/10.2967/jnumed.107.047787
  9. Shin KM, Lee KS, Shim YM, Kim J, Kim BT, Kwon OJ, et al. FDG PET/CT and mediastinal nodal metastasis detection in stage T1 non-small cell lung cancer: prognostic implications. Korean J Radiol 2008;9:481-489 https://doi.org/10.3348/kjr.2008.9.6.481
  10. Baek CH, Chung MK, Jeong HS, Son YI, Choi J, Kim YD, et al. The clinical usefulness of (18)F-FDG PET/CT for the evaluation of lymph node metastasis in periorbital malignancies. Korean J Radiol 2009;10:1-7 https://doi.org/10.3348/kjr.2009.10.1.1
  11. Adams S, Baum RP, Stuckensen T, Bitter K, Hor G. Prospective comparison of 18F-FDG PET with conventional imaging modalities (CT, MRI, US) in lymph node staging of head and neck cancer. Eur J Nucl Med 1998;25:1255-1260 https://doi.org/10.1007/s002590050293
  12. Ng SH, Yen TC, Liao CT, Chang JT, Chan SC, Ko SF, et al. 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med 2005;46:1136-1143
  13. Byers RM, El-Naggar AK, Lee YY, Rao B, Fornage B, Terry NH, et al. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue? Head Neck 1998;20:138-144 https://doi.org/10.1002/(SICI)1097-0347(199803)20:2<138::AID-HED7>3.0.CO;2-3
  14. Werning JW, Heard D, Pagano C, Khuder S. Elective management of the clinically negative neck by otolaryngologists in patients with oral tongue cancer. Arch Otolaryngol Head Neck Surg 2003;129:83-88 https://doi.org/10.1001/archotol.129.1.83
  15. Minn H, Lapela M, Klemi PJ, Grenman R, Leskinen S, Lindholm P, et al. Prediction of survival with fluorine-18-fluoro-deoxyglucose and PET in head and neck cancer. J Nucl Med 1997;38:1907-1911
  16. Allal AS, Slosman DO, Kebdani T, Allaoua M, Lehmann W, Dulguerov P. Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F] fluoro-2-deoxy-D-glucose. Int J Radiat Oncol Biol Phys 2004;59:1295-1300 https://doi.org/10.1016/j.ijrobp.2003.12.039
  17. Choi KH, Yoo IR, Han EJ, Kim YS, Kim GW, Na SJ, et al. Prognostic value of metabolic tumor volume measured by 18F-FDG PET/CT in locally advanced head and neck squamous cell carcinomas treated by surgery. Nucl Med Mol Imaging 2011;45:43-51 https://doi.org/10.1007/s13139-010-0063-7
  18. Hyun SH, Choi JY, Shim YM, Kim K, Lee SJ, Cho YS, et al. Prognostic value of metabolic tumor volume measured by 18F-fluorodeoxyglucose positron emission tomography in patients with esophageal carcinoma. Ann Surg Oncol 2010;17:115-122 https://doi.org/10.1245/s10434-009-0719-7
  19. Kim BS, Kim IJ, Kim SJ, Nam HY, Pak KJ, Kim K, et al. The prognostic value of the metabolic tumor volume in FIGO stage IA to IIB cervical cancer for tumor recurrence: Measured by F-18 FDG PET/CT. Nucl Med Mol Imaging 2011;45:36-42 https://doi.org/10.1007/s13139-010-0062-8
  20. Chung MK, Jeong HS, Son YI, So YK, Park GY, Choi JY, et al. Metabolic tumor volumes by [18F]-fluorodeoxyglucose PET/CT correlate with occult metastasis in oral squamous cell carcinoma of the tongue. Ann Surg Oncol 2009;16:3111-3117 https://doi.org/10.1245/s10434-009-0621-3
  21. Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlein M, Guermazi A, et al. Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol 2007;25:571-578 https://doi.org/10.1200/JCO.2006.08.2305
  22. Lee P, Weerasuriya DK, Lavori PW, Quon A, Hara W, Maxim PG, et al. Metabolic tumor burden predicts for disease progression and death in lung cancer. Int J Radiat Oncol Biol Phys 2007;69:328-333 https://doi.org/10.1016/j.ijrobp.2007.04.036
  23. Nestle U, Kremp S, Schaefer-Schuler A, Sebastian-Welsch C, Hellwig D, Rube C, et al. Comparison of different methods for delineation of 18F-FDG PET-positive tissue for target volume definition in radiotherapy of patients with non-small cell lung cancer. J Nucl Med 2005;46:1342-1348
  24. Roh JL, Pae KH, Choi SH, Kim JS, Lee S, Kim SB, et al. 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography as guidance for primary treatment in patients with advanced-stage resectable squamous cell carcinoma of the larynx and hypopharynx. Eur J Surg Oncol 2007;33:790-795 https://doi.org/10.1016/j.ejso.2007.01.002
  25. La TH, Filion EJ, Turnbull BB, Chu JN, Lee P, Nguyen K, et al. Metabolic tumor volume predicts for recurrence and death in head-and-neck cancer. Int J Radiat Oncol Biol Phys 2009;74:1335-1341 https://doi.org/10.1016/j.ijrobp.2008.10.060
  26. Daisne JF, Duprez T, Weynand B, Lonneux M, Hamoir M, Reychler H, et al. Tumor volume in pharyngolaryngeal squamous cell carcinoma: comparison at CT, MR imaging, and FDG PET and validation with surgical specimen. Radiology 2004;233:93-100 https://doi.org/10.1148/radiol.2331030660
  27. Chan SC, Chang JT, Lin CY, Ng SH, Wang HM, Liao CT, et al. Clinical utility of 18F-FDG PET parameters in patients with advanced nasopharyngeal carcinoma: predictive role for different survival endpoints and impact on prognostic stratification. Nucl Med Commun 2011;32:989-996 https://doi.org/10.1097/MNM.0b013e3283495662
  28. Moon SH, Choi JY, Lee HJ, Son YI, Baek CH, Ahn YC, et al. Prognostic value of (18) F-FDG PET/CT in patients with squamous cell carcinoma of the tonsil: Comparisons of volume-based metabolic parameters. Head Neck 2012; dol:10.1002/hed.22904 [Epub ahead of print]
  29. Hatt M, Visvikis D, Pradier O, Cheze-le Rest C. Baseline $^{18}F$-FDG PET image-derived parameters for therapy response prediction in oesophageal cancer. Eur J Nucl Med Mol Imaging 2011;38:1595-1606 https://doi.org/10.1007/s00259-011-1834-9

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