Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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Rare Frameshift Mutation $Cys475Tyrfs^*$11 in the BCR/ABL Kinase Domain Contributes to Imatinib Mesylate Resistance in 2 Korean Patients with Chronic Myelogenous Leukemia

  • Park, Sang Hyuk (Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine) ;
  • Chi, Hyun-Sook (Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine) ;
  • Kwon, Mi-Ryang (Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine) ;
  • Cho, Young-Uk (Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine) ;
  • Jang, Seongsoo (Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine) ;
  • Park, Chan-Jeoung (Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine)
  • Published : 2012.11.01
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References

  1. Soverini S, Hochhaus A, Nicolini FE, Gruber F, Lange T, Saglio G, et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood 2011;118:1208-15. https://doi.org/10.1182/blood-2010-12-326405
  2. Soverini S, Martinelli G, Amabile M, Poerio A, Bianchini M, Rosti G, et al. Denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib. Clin Chem 2004;50:1205-13. https://doi.org/10.1373/clinchem.2004.031112
  3. Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, et al. (Eds.), Catalogue of Somatic Mutations in Cancer. http://www.sanger.ac.uk/genetics/CGP/cosmic (last updated on 12 Mar 2012).
  4. Strhakova L, Bujalkova MG, Hojsikova I, Lukackova R, Behulova R, Mistrik M, et al. Use of direct sequencing for detection of mutations in the BCR-ABL kinase domain in Slovak patients with chronic myeloid leukemia. Neoplasma 2011;58:548-53. https://doi.org/10.4149/neo_2011_06_548

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  1. The landscape of BCR‐ABL mutations in patients with Philadelphia chromosome‐positive leukaemias in the era of second‐generation tyrosine kinase inhibitors vol.38, pp.3, 2012, https://doi.org/10.1002/hon.2721
  2. Spectrum of BCR-ABL Mutations and Treatment Outcomes in Ethiopian Imatinib-Resistant Patients With Chronic Myeloid Leukemia vol.7, pp.None, 2012, https://doi.org/10.1200/go.21.00058