Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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Changes in the Levels of Interleukins 6, 8, and 10, Tumor Necrosis Factor Alpha, and Granulocyte-colony Stimulating Factor in Korean Burn Patients: Relation to Burn Size and Postburn Time

  • Kim, Hyun Soo (Department of Laboratory Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Jong-Hyun (Department of General Surgery, Hangang Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Yim, Haejun (Department of General Surgery, Hangang Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Dohern (Department of General Surgery, Hangang Sacred Heart Hospital, Hallym University College of Medicine)
  • Published : 2012.09.01
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Abstract

Background: Major burn injury induces an inflammatory response that is accompanied by the release of various cytokines. We investigated the gradual changes in the levels of pro-inflammatory and anti-inflammatory cytokines following burn injury and determined the relationship between these levels and burn size in adult Korean patients with burn injury. Methods: Blood samples from 9 healthy controls and 60 Korean burn patients were collected on days 1, 3, 7, 14, and 21 after burn injury, and concentrations of interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF)-${\alpha}$, and granulocyte-colony stimulating factor (GCSF) were measured. Burn patients were divided into 3 groups according to burn size (15-30%, 31-50%, >50% total body surface area), and the concentrations of the cytokines were compared between these groups and the control group over 3 weeks. Results: Compared to their levels in controls, IL-6, IL-8, IL-10, TNF-${\alpha}$, and G-CSF levels in burn patients were significantly higher during the observation period. Median concentrations of IL-8, IL-10, and G-CSF at each time point increased with burn size, although peak levels and time to peak levels of these cytokines differed from patient to patient. Conclusions: These findings indicate that IL-6, IL-8, IL-10, TNF-${\alpha}$, and G-CSF are important mediators in inflammatory changes after burn injury; however, various factors, including burn size, may influence the concentrations of these cytokines.

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References

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