The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Endoscopic Findings and Follow-Up of Gastric MALT Lymphoma

위 MALT 림프종의 내시경적 소견과 추적관찰

  • No, Jin Hee (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Lee, In Seok (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • 노진희 (가톨릭대학교 의과대학 내과학교실) ;
  • 이인석 (가톨릭대학교 의과대학 내과학교실)
  • Published : 2012.12.01
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Abstract

Gastric mucosa-associated lymphoid tissue (MALT) lymphomas comprise over 50% of primary gastric non-Hodgkin lymphomas and show an increasing incidence. Pathogenesis is often related to Helicobacter pylori infection (HPI). Howevere, endoscopic findings of MALT lymphoma are nonspecific and diagnosis is difficult by the naked eye due to various endoscopic appearances such as erosion, erythema, ulceration, atrophy and submucosal mass. Diagnosis is based on the histopathologic evaluation of multiple, deep and repeated biopsies taken from normal and any abnormal appearing sites of the stomach. Endoscopic ultrasound (EUS) can aid in accurate diagnosis, staging, and prediction of prognosis in gastric MALT lymphoma. After treatment of primary gastric lymphoma, EUS produces conflicting results that are not as accurate as endoscopy with biopsy. Therefore, EUS is not mandatory during follow-up. A first evaluation of lymphoma regression should be performed 3-6 months after completion of treatment. Further follow-up should be performed every 4-6 months thereafter until complete remission of lymphoma is documented. Gastroscopy with multiple biopsies has to be performed. Additionally, the initial sites of lymphoma involvement should be checked by appropriate methods. If complete remission of gastric MALT lymphoma is achieved, follow-up gastroscopies with biopsies seem advisable.

Keywords

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