Abstract
Neuropsychiatric events are common in patients with systemic lupus erythematosus (SLE). The estimated incidence of neuropsychiatric SLE (NPSLE) is 30 to 40%. However, NPSLE poses a difficult diagnostic challenge because a variety of conditions should be considered in the differential diagnosis, especially when patients present with uncommon or rare NPSLE features. We herein describe a 49-year-old man with SLE who initially presented with diplopia, ptosis, and gait disturbance that had developed 1 week after an upper respiratory tract infection. He was finally diagnosed with Miller Fisher syndrome (a variant of Guillain-$Barr{\acute{e}}$ syndrome) according to clinical symptoms, anti-GQ1b antibody positivity, and neurological study results. The patient recovered without sequelae with intravenous immunoglobulin therapy. This is the first report to describe a case of Miller Fisher syndrome that developed in a patient with SLE in Korea and suggests that Miller Fisher syndrome should be included as a differential diagnosis of NPSLE.
전신홍반루푸스에서 신경정신학적 증상은 흔하지만, 드물게 나타나는 뇌신경 장애나 다발성 신경병증에 대한 감별에는 여러 가지 질환들이 포함된다. 저자들은 전신홍반루푸스로 치료받고 있던 남자 환자에서 상기도 감염력이 있은 후 발생한 복시, 안검하수, 운동실조로 내원하여 신경학적 검사 및 항 GQ1b항체 검사를 통해 진단된 Miller Fisher 증후군을 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.