Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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A Case of Rosai-Dorfman Disease with Highly Elevated Serum Ferritin

  • Rew, Sung-Yoon (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Jang, Hee-Chang (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Park, Kyung-Hwa (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Ahn, Jae-Sook (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Kim, Ga-Eon (Department of Pathology, Chonnam National University Medical School) ;
  • Choi, Yoo-Duk (Department of Pathology, Chonnam National University Medical School) ;
  • Jung, Sook-In (Department of Internal Medicine, Chonnam National University Medical School)
  • Published : 2012.03.01
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Abstract

Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease is a rare disorder characterized by proliferation of distinctive histiocytes within lymph node sinuses and lymphatics, sometimes involving extranodal sites. However, clinical suspicion is difficult and there is also a lack of useful diagnostic markers for this disorder prior to histological confirmation. High elevation of serum ferritin is known to be a useful diagnostic marker for various hematologic diseases, including hemophagocytic lymphohistiocytosis and lymphoma. Here, we report a case of fever of unknown origin that presented along with highly elevated serum ferritin (5,780 ng/mL), and was finally diagnosed as Rosai-Dorfman disease by lymph node biopsy.

Keywords

References

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