Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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Relationship of Oxidative Stress in Hepatitis B Infection Activity with HBV DNA and Fibrosis

  • Duygu, Fazilet (Department of Infectious Disease and Clinic Microbiology, Tokat State Hospital) ;
  • Karsen, Hasan (Department of Infectious Disease and Clinic Microbiology, Faculty of Medicine, Harran University) ;
  • Aksoy, Nurten (Department of Biochemistry, Faculty of Medicine, Harran University) ;
  • Taskin, Abdullah (Department of Biochemistry, Faculty of Medicine, Harran University)
  • Published : 2012.03.01
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Abstract

Background: The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease. Methods: Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults were included in the study. The following values were measured and compared in patient groups: total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation (LOOH), catalase (CAT), and ceruloplasmin. In patients with chronic hepatitis B, these values were compared with HBV DNA and fibrosis levels. Results: ALT, TOS, LOOH, and OSI levels were higher in the CHB group compared to the other groups (P <0.001). Catalase levels increased in the CHB and IHBCS groups compared to the control group (P <0.001). Total aminooxidant and ceruloplasmin levels were found to be lowest in the CHB group and highest in the control group (P <0.001). Sulfhyrdyl was higher in the control group compared to the other groups (P <0.001). In the CHB group, there was no correlation between the HBV DNA and OSI (P >0.05). Conclusions: These finding suggested that oxidative stress is associated with hepatitis B activity.

Keywords

References

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