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Epigenetic Regulation of RUNX3 in Thyroid Carcinoma

  • Joung, Kyong Hye (Research Center for Endocrine and Metabolic Diseases, Department of Internal Medicine, Chungnam National University School of Medicine) ;
  • Shong, Minho (Research Center for Endocrine and Metabolic Diseases, Department of Internal Medicine, Chungnam National University School of Medicine)
  • Published : 2012.12.01

Abstract

Keywords

References

  1. Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell 2012;150:12-27. https://doi.org/10.1016/j.cell.2012.06.013
  2. Baylin SB, Jones PA. A decade of exploring the cancer epigenome: biological and translational implications. Nat Rev Cancer 2011;11:726-734. https://doi.org/10.1038/nrc3130
  3. Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 2006;5:37-50. https://doi.org/10.1038/nrd1930
  4. Xing M. Gene methylation in thyroid tumorigenesis. Endocrinology 2007;148:948-953. https://doi.org/10.1210/en.2006-0927
  5. Hu S, Liu D, Tufano RP, et al. Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer 2006;119:2322-2329. https://doi.org/10.1002/ijc.22110
  6. Porra V, Ferraro-Peyret C, Durand C, et al. Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas. J Clin Endocrinol Metab 2005;90:3028-3035. https://doi.org/10.1210/jc.2004-1394
  7. Schneider-Stock R, Roessner A, Ullrich O. DAP-kinase: protector or enemy in apoptotic cell death. Int J Biochem Cell Biol 2005;37:1763-1767. https://doi.org/10.1016/j.biocel.2005.02.019
  8. Weisenberger DJ, Siegmund KD, Campan M, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006;38:787-793. https://doi.org/10.1038/ng1834
  9. Blyth K, Cameron ER, Neil JC. The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer 2005;5:376-387. https://doi.org/10.1038/nrc1607
  10. Kim TY, Lee HJ, Hwang KS, et al. Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma. Lab Invest 2004;84:479-484. https://doi.org/10.1038/labinvest.3700060
  11. Ko HJ, Kim BY, Jung CH, et al. DNA methylation of RUNX3 in papillary thyroid cancer. Korean J Intern Med 2012;27:407-410. https://doi.org/10.3904/kjim.2012.27.4.407

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