Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Dosimetric Verification for Primary Focal Hypermetabolism of Nasopharyngeal Carcinoma Patients Treated with Dynamic Intensity-modulated Radiation Therapy

  • Xin, Yong (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital) ;
  • Wang, Jia-Yang (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital) ;
  • Li, Liang (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital) ;
  • Tang, Tian-You (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital) ;
  • Liu, Gui-Hong (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital) ;
  • Wang, Jian-She (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital) ;
  • Xu, Yu-Mei (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital) ;
  • Chen, Yong (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital) ;
  • Zhang, Long-Zhen (Department of Radiatiotherapy, Xuzhou Medical College Affiliated Hospital)
  • Published : 2012.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: To make sure the feasibility with $^{18F}FDG$ PET/CT to guided dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma patients, by dosimetric verification before treatment. Methods: Chose 11 patients in III~IVA nasopharyngeal carcinoma treated with functional image-guided IMRT and absolute and relative dosimetric verification by Varian 23EX LA, ionization chamber, 2DICA of I'mRT Matrixx and IBA detachable phantom. Drawing outline and making treatment plan were by different imaging techniques (CT and $^{18F}FDG$ PET/CT). The dose distributions of the various regional were realized by SMART. Results: The absolute mean errors of interest area were $2.39%{\pm}0.66$ using 0.6cc ice chamber. Results using DTA method, the average relative dose measurements within our protocol (3%, 3 mm) were 87.64% at 300 MU/min in all filed. Conclusions: Dosimetric verification before IMRT is obligatory and necessary. Ionization chamber and 2DICA of I'mRT Matrixx was the effective dosimetric verification tool for primary focal hyper metabolism in functional image-guided dynamic IMRT for nasopharyngeal carcinoma. Our preliminary evidence indicates that functional image-guided dynamic IMRT is feasible.

Keywords

References

  1. Agazaryan N, Solberg TD, DeMarco JJ (2003) Patient specific quality assurance for the delivery of intensity modulated radiotherapy. J Applied Clinical Med Phys, 4, 40-50. https://doi.org/10.1120/1.1525243
  2. Bo PG, Zhang XC, Pan JJ, et al (2006). Static intensitymodulated radiotherapy design and 30 cases dose verification analysis. Fu Jian Med University J, 40, 248-50.
  3. Bortfeld T, Boyer AL, Schlegel W, Kahler DL, Waldron TJ (1994). Realizationand verification of three-dimensional conformal radiotherapy with modulated fields. Int J Radiat Onco Biol Phys, 30, 899-908. https://doi.org/10.1016/0360-3016(94)90366-2
  4. Hu YM editor (1999). Tumor radiation physics. Atomic energy press, Beijing pp 328-41.
  5. Intensity Modulated Radiation Therapy Collaborative Working Group (2001). Intensity-modulated Radiotherapy: Current status and issues of interest. Int J RadiationOncology Biol Phys, 51, 880-914. https://doi.org/10.1016/S0360-3016(01)01749-7
  6. Kam MK, Leung SF, Zee B, et al (2007). Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J Clin Oncol, 25, 4873-9. https://doi.org/10.1200/JCO.2007.11.5501
  7. Leybovich LB, Sethi A, Dogan N (2003). Comparison of ionization chamhers of various volumes for IMRT absolute dose verification. Med Plays, 30, 119-23.
  8. Li GF, Zhu MS, Wu QH, et al (2002). Clinical quality assurance of intensity modulated radiation therapy. Chin J Radiat Oncol, 11, 190-3.
  9. Li L, Dai JR, Jiang B, Ma P (2010). The relation of the dose distributions with the dose rates in static intensity modulated radiotherapy using Varian's linear accelarator. Chin J Radiat Oncol, 19, 268-72.
  10. Litters DW, Moran JM, Fraas BA (2002). Verfiation of dynamic and segmental IMRT delivery by dynamic log file analysis. J Appl Clin Med Phys, 3, 63-72. https://doi.org/10.1120/1.1449362
  11. Low DA, Harms WB, Mutic S, Purdy JA (1998). A technique for quantitative evaluation of dose distribufiong. Med Phys, 25, 656-61. https://doi.org/10.1118/1.598248
  12. Pow EH, Kwong DL, McMillan AS, et al (2006). Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trial. Int J Radiat Oncol Biol Phys, 66, 981-91. https://doi.org/10.1016/j.ijrobp.2006.06.013
  13. Sanguineti G, Geara FB, Garden AS, et al (1997). Carcinoma of the nasophynx treated by radiotherapy alone: determinants of local and regional control. Int Radiat Oncol Biol Phys, 37, 985-6. https://doi.org/10.1016/S0360-3016(97)00104-1
  14. Tsai JS, Wazer DE, Ling MN, et al (1998). Dosimetric verification of the dynamic intensity modulated radiation therapy of 92 patients. Int J Radiat Oncol Biol Phys, 40, 1213-30. https://doi.org/10.1016/S0360-3016(98)00009-1
  15. Wang J, Guo LP, Chen LZ, Zeng YX, Lu SH (2007). Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Cancer Rse, 67, 3716-24. https://doi.org/10.1158/0008-5472.CAN-06-4343
  16. Xiao F, Sun CY, Shi M (2007). Plan-specific dosimetrverification for nasopharyngeal carcinoma patient treated with dynamic intensity-modulated radiation on therapy. Modern Oncology, 15, 178-80.
  17. Yu JM, Liu NB (2009). FDG-PET/CT nasopharyngeal carcinoma radiotherapy in stage and the progress in the research. Chin J Oncol and Treat, 1, 95-104.
  18. Yu JM, Liu NB (2009). Non-small cell lung cancer the epidermal growth factor receptor molecular imaging research progress. Chin J Oncol, 2, 81-4.
  19. Zhang SX, Zhou LH, Chen GJ, et al (2009). Research on the application of 2-D air vented ionization chamber array MatriXX system. Chin J Radiol Med Prot, 29, 93-6.
  20. Zhang XJ, Wang JH, Tu Y (2007). Dosimetric verification for nasopharyngeal carcinoma patient treated with intensity modulated radiation therapy. Int Nuclear Med J Radiol, 31, 318-20.
  21. Zhou YB (2008). Methods and dose verification of conformal radiotherapy with integrated blocks. China Med Equip, 23, 17-8.

Cited by

  1. Planning and Dosimetric Study of Volumetric Modulated Arc Based Hypofractionated Stereotactic Radiotherapy for Acoustic Schwannoma - 6MV Flattening Filter Free Photon Beam vol.16, pp.12, 2015, https://doi.org/10.7314/APJCP.2015.16.12.5019