Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Quality of Life in Malaysian Colorectal Cancer Patients : A Preliminary Result

  • Natrah, M.S. (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Ezat, Sharifa W.P. (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Syed, M.A. (United Nations University-International Institute for Global Health) ;
  • Rizal, A.M. Mohd (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre) ;
  • Saperi, S. (Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre)
  • Published : 2012.03.31
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Abstract

Objective: Rapidly increasing colorectal cancer (CRC) incidence in Malaysia and the introduction of cutting edge new treatments, which prolong survival, mean that treatment outcome measures meed to be evaluated, including consideration of patient's quality of life (QoL) assessment. There are limited data on QoL in CRC patients, especially in Malaysia. Therefore, this study was performed focusing on cancer stages and age groups. Methods: The cross sectional study was conducted from June to September 2011 at three public tertiary hospitals with the EORTC QLQ C-30 questionnaire in addition to face to face interview and review of medical records of 100 respondents. Results: The mean age was 57.3 (SD 11.9) years with 56.0% are males and 44.0% females, 62% of Malay ethnicity, 30% Chinese, 7% Indian and 1% Sikh. Majority were educated up to secondary level (42%) and 90% respondents had CRC stages III and IV. Mean global health status (GHS) score was 79.1 (SD 21.4). Mean scores for functional status (physical, emotional, role, cognitive, social) rangeds between 79.5 (SD 26.6) to 92.2 (SD 13.7). Mean symptom scores (fatigue, pain, nausea/vomiting, constipation, diarrhea, insomnia, dyspnoea, loss of appetite) ranged between 4.00 (SD 8.58) to 20.7 (SD 30.6). Respondents role function significantly deteriorates with increasing stage of the disease (p=0.044). Females had worse symptoms of pain (p=0.022), fatigue (p=0.031) and dyspnoea (p=0.031). Mean insomnia (p=0.006) and diarrhea (p=0.024) demonstrated significant differences between age groups. Conclusion: QOL in CRC patients in this study was comparable to that in other studies done in developed countries. Pain, fatigue and dyspnoea are worse among female CRC patients. Given that functions deteriorates with advanced stage of the disease at diagnosis, a systematic screening programme to detect cases as early as possible is essential nationwide.

Keywords

References

  1. Aaronson NK, Ahmedzai S, Bergman B, et al (1993). The European Organisation for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst, 85, 365-76. https://doi.org/10.1093/jnci/85.5.365
  2. Au HJ, Karapetis CS, O'Callaghan CJ, et al (2009). Healthrelated quality of life in patients with advanced colorectal cancer treated with cetuximab: overall and KRAS-specific results of the NCIC CTG and AGITG CO.17 Trial. J Clin Oncol, 27, 1822-8. https://doi.org/10.1200/JCO.2008.19.6048
  3. Azmi MN, Zailani MA, Norashikin MN (2007). Five-year review of histopathological findings of colorectal cancer patients operated in Hospital Tengku Ampuan Afzan Kuantan Pahang Malaysia. Int Med J, 6, 15-20.
  4. Bottomley A (2002). The cancer patient and quality of life. The Oncologist, 7,120-5. https://doi.org/10.1634/theoncologist.7-2-120
  5. Braun DP, Gupta D, Grutsch JF (2011). Can changes in health related quality of life scores predict survival in stages III and IV colorectal cancer?. Health Quality of Life Outcomes, 9, 2-8. https://doi.org/10.1186/1477-7525-9-2
  6. Cancer Research UK. Cancer Stats Key Facts. 2010. http://www.cancercenter.com/colon-cancer/quality-life.cfm (25 Oct. 2011)
  7. Center MM, Jemal A, Ward E (2009). International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers, 18, 1688-94. https://doi.org/10.1158/1055-9965.EPI-09-0090
  8. Ellenbecker E (2008). Patient Safety and Quality: An Evidence- Based Handbook for Nurses. Hughes RG (ed). Rockville (MD): Agency for Healthcare Research and Quality (US); AHRQ Publication No. 08-0043. Rockville.
  9. Engel J, Kerr J, Schlesinger-Raab A (2003). Quality of Life in Rectal Cancer Patients: A Four-Year Prospective Study. Ann Surg, 238, 203-13.
  10. Fayers PM, Aaronson NK, Bjordal K, et al (2001) on behalf of the EORTC Quality of Life Group. The EORTC QLQ-C30 Scoring Manual (3rd Edition). Published by: European Organisation for Research and Treatment of Cancer, Brussels 2001.
  11. Hyodo I, Suzuki H, Takahashi K, et al (2010). Present status and perspectives of colorectal cancer in Asia: Colorectal Cancer Working Group Report in 30th Asia-Pacific Cancer Conference. Jpn J Clin Oncol, 40, 38-43. https://doi.org/10.1093/jjco/hyq125
  12. Jemal A, Siegel R, Ward E, et al (2008) Cancer statistics. CA: A Cancer J Clin, 58, 71-96. https://doi.org/10.3322/CA.2007.0010
  13. Kong CK, Roslani AC, Law CW, et al (2010). Impact of socioeconomic Class on Colorectal Cancer Patient Outcomes in Kuala Lumpur and Kuching, Malaysia. APJCP, 11, 969-74.
  14. Mandelblatt J, Andrews H, Kao R (1996). The Late-Stage Diagnosis of Colorectal Cancer: Demographic and Socioeconomic Factors. Am J Public Health, 86, 1794-7. https://doi.org/10.2105/AJPH.86.12.1794
  15. McArdle CS, McMillan DC, Hole DJ (2003). Male gender adversely affects survival following surgery for colorectal cancer. Bri J Surg, 90, 711-5. https://doi.org/10.1002/bjs.4098
  16. National Cancer Registry, Ministry of Health Malaysia (2006). Malaysian Cancer Statistics - Data And Figure Peninsular Malaysia 2006.
  17. Ruste SA, Ngelangel C (2011). QoL of Colorectal Cancer Stoma Patients at the Philippine General Hospital - Cancer Institute. Philipine J Int Med, 49, 38-42.
  18. Sanoff HK, Sargent DJ, Green EM (2009). Racial differences in advanced colorectal cancer outcomes and pharmacogenetics: A subgroup analysis of a large randomized clinical trial. J Clin Oncol, 27, 4109-15. https://doi.org/10.1200/JCO.2009.21.9527
  19. Schmidt CE, Bestmann B, Küchler T (2005). Gender differences in quality of life of patients with rectal cancer. A five-year prospective study. World J Surg, 29, 1630-41. https://doi.org/10.1007/s00268-005-0067-0
  20. Tsunoda A, Nakao K, Hiratsuka K (2005). Anxiety, depression and quality of life in colorectal cancer patients. Int J Clinical Oncol, 10, 411-7. https://doi.org/10.1007/s10147-005-0524-7
  21. Watson M (2001). Psychosocial issues in cancer. Current Science, 81, 566-70.
  22. Yusoff N, Low WY, Yip CH (2010). The Malay Version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ C30): Reliability and Validity Study. Int Med J Malaysia, 9, 45-50.

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