Journal of Integrative Natural Science (통합자연과학논문집)

The Basic Science Institute Chosun University (조선대학교 기초과학연구원)
권호 표지
DOI QR코드

DOI QR Code

A Prospective study of Anti-Diabetic activity of Lagerstroemia speciosa Linn.

  • Merlin Jayalal, L.P. (Department of Biochemistry, Bharathidasan college of Arts and Science)
  • Received : 2012.05.13
  • Accepted : 2012.06.24
  • Published : 2012.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Herbal medicines have been used since the dawn of civilization to maintain health and to treat diseases. Diabetes mellitus is one of the leading cause of death in many developed countries. The incidence of diabetes is increasing at an alarming rate in India. It was estimated that India which had 19.4 million diabetes in 1995 is expected to register a near threefold increase by. Many plants reported to be useful for the treatment of diabetes mellitus in ayurvedic medicine, are being tested for their hypoglycemic activity in experimental animals Lagerstroemia flos- reginae is one such plant commonly found as shade trees in Kerala. In Ayurveda both root and leaves are used in the treatment of diabetes. The main objective of this study was to assess the antidiabetic effect of the alcohol extracted leaves of Lagerstroemia flos- reginae in alloxan induced diabetic rats in terms of controlling blood glucose level, lipid profile, bilirubin, uric acid in serum and lipid peroxides and glutathione in the liver of the experimental animals. The present study has been undertaken to observe the protective effect of the active constituents of Lagerstroemia flos- reginae leaf extracts against alloxan induced diabetes in experimental animal model. The activity of the active constituents was compared with Daonil -a standard drug.

Keywords

References

  1. K. S. Ahn, M. S. Hahm, and E. J. Park, "Corosolic acid isolated from the fruit of Crataegus pinnatifidavarpilosa is a protein kinase inhibitor as well as a cytotoxic agent", Planta Medica, et al., Vol. 6 pp. 468-470, 1998.
  2. L. Ali, A. K. Azad Khan, Z. Hassan, M. Mosihuzzaman, N. Nahar, T. Nasr, M. Nur-e-Alam, and B. Rokeya, "Studies of Hypoglycemic effect of Fruit pulp, Seed and whole plant of Momordica charantia on normal and diabetic model rats", Planta Medica, Vol. 7, 1993.
  3. L. Ali, A. K. Azad Khan, Z. Hassan, M. Mosihuzzaman, N. Nahar, T. Nasr, M. Nur-e-Alam, and B. Rokeya, "Characteriziation of Hypoglycemic effect of Trigonella foenum graceum seed", Planta Medica, Vol. 61, No. 4, pp. 358-360, 1995. https://doi.org/10.1055/s-2006-958100
  4. S. M. AL-Khazraji, L.A. al-Shamony, and H. A. Twaij , "Hypoglycemic effect of Artemisia herba alba; Journal of Ethamopharmacology", Vol. 40, pp. 163-166, 1993. https://doi.org/10.1016/0378-8741(93)90064-C
  5. T. Amalraj, and S. Ignacimuthu, "Anti diabetic properties of bitter melon", Journal of American Botanical Council, Vol. 39, p.18, 1997.
  6. T. Amalraj, and S. Ignacimuthu, "Hypoglycemic activity of Cajanus cajan in mice", Indian Journal of Experimental Biology, Vol. 36, pp. 1032-1033, 1998.
  7. Andrew Gaeddert. 2002 Dec. "Townsend letter for Doctors and patients"
  8. C. V. Anuradha, and P. Ravikumar, "Indian Journal of Pharmacology", Vol. 45, No. 4 pp. 408-420, 2001.
  9. B. V. Babu , "Screening of hypoglycemic activity", Indian Journal of Bio-Chemistry, Vol. 25, No. 6, pp. 714-715, 1998.
  10. V. Babu, and T. Ganga Devi, "Anti Hyperglycemic activity of Cassia kleinii leaf extract in glucose fed normal and alloxan induced diabetic rats", Indian Journal of Pharmacology, Vol. 34, pp. 409-415, 2002.
  11. V. Babu, T. Ganga Devi, and A1. Subramonian. "Anti Hyperglycemic activity of Cassia kleinii leaf extract in glucose fed normal and alloxan induced diabetic rats", Indian Journal of Pharmacology, Vol. 35, pp. 290-296, 2003.
  12. H. U. Bagmeyer, "Clinical Chemistry", Vol. 18, 1972.
  13. N. G. Bandyopadhyay, B. K. Choudry, and A. Kar, "Comparitive evaluation of hypoglycemic activity of some Indian Medicinal plants in alloxan diabetic rats", Journal of Ethanopharmacology, Vol. 84, pp. 105-108, 2003. https://doi.org/10.1016/S0378-8741(02)00144-7
  14. V. Bahvapriya, and S. Kalpana, "Biochemical studies on hypoglycemic effect of Avirai kudineer a herbal formulation in aloxan diabetic rats", Indian journal of clinical Biochemistry, Vol. 17, No. 2, pp.70-73, 2000.
  15. G. Bucolo, and M. David, "Clinical Chemistry", Vol. 19, p. 476, 1973.
  16. S. R. Cantharine, and G. Paul, "Journal of Nutrition", Vol. 39, p. 529, 1949. https://doi.org/10.1093/jn/39.4.529
  17. B. Chandrasekar, B. Mukherjee, and S.K. Mukherjee, "Blood sugar lowering effect of Tricosanther dioica Roxb. In experimental rat models", Indian journal of Crude drug research, Vol. 26, No. 2, pp.102-106, 1998.
  18. T. K. Chatterjee, "Medicinal plants used as antidiabetic agents Herbal opt" Eastern traders, Vol. 60, 1997.