YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antihypertensive and ACE Inhibitory Effects of Novel Isoflavone-free Black Soy Peptide Mixture

Isoflavone-Free 검은콩펩타이드의 항고혈압 및 ACE 활성 억제효과

  • Ahn, Chang-Won (R&BD Center, NongShim Co. Ltd.) ;
  • Shin, Dong-Seok (R&BD Center, NongShim Co. Ltd.) ;
  • Park, Soo-Hyun (R&BD Center, NongShim Co. Ltd.) ;
  • Hong, Soon-Sun (Department of Biomedical Sciences and Clinical Research Center, Inha University) ;
  • Kang, Ju-Hee (Department of Pharmacology and Medicinal Toxicology Research Center, Center for Advanced Medical Education, Inha University College of Medicne by BK-21 Project, Inha University) ;
  • Park, Chang-Shin (Department of Pharmacology and Medicinal Toxicology Research Center, Center for Advanced Medical Education, Inha University College of Medicne by BK-21 Project, Inha University)
  • 안창원 ((주)농심 R&BD 센터) ;
  • 신동석 ((주)농심 R&BD 센터) ;
  • 박수현 ((주)농심 R&BD 센터) ;
  • 홍순선 (인하대학교 의과대학 의학전문대학원 특성화교실 임상시험센터) ;
  • 강주희 (약리학교실 의약물독성연구소) ;
  • 박창신 (약리학교실 의약물독성연구소)
  • Received : 2012.09.07
  • Accepted : 2012.10.30
  • Published : 2012.10.31
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Abstract

Antiobesity, hypotriglyceridemic and antihypertensive activities of isoflavone-free peptide mixture (black soybean peptide, BSP) were reported in our previous experiments. In the present study, angiotensin converting enzyme inhibitory (ACEi) activity was decreased in the aorta tissues of spontaneously hypertensive rats (SHRs) treated with BSP (1% in drink water) for 4 weeks, but not in serum. BSP administration significantly decreased ACE activity by 17.5% (from $33.2{\pm}4.5$ to $27.4{\pm}1.96$ mUnit/mg, p=0.0013) in aorta tissue hydrolysate. BSP treatment also decreased significantly mean blood pressure (BP) (from $213.0{\pm}16.96$ to $184.0{\pm}6.53$ mmHg, p<0.0001) as expected. These results indicate that BSP has antihypertensive activity as well as ACEi activity.

Keywords

References

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