YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Neuroprotectuve Effect of Homosyringaldehyde Isolated from Cynanchum panuculatum against Glutamate-Induced Neurotoxicity

서장경으로부터 분리한 Homosyringaldehyde의 뇌신경세포 보호 활성

  • Weon, Jin Bae (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Lee, Bohyoung (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Yun, Bo-Ra (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Lee, Jiwoo (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University) ;
  • Ma, Choong Je (Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University)
  • 원진배 (강원대학교 의생명소재공학전공) ;
  • 이보형 (강원대학교 의생명소재공학전공) ;
  • 윤보라 (강원대학교 의생명소재공학전공) ;
  • 이지우 (강원대학교 의생명소재공학전공) ;
  • 마충제 (강원대학교 의생명소재공학전공)
  • Received : 2012.06.29
  • Accepted : 2012.09.22
  • Published : 2012.10.31
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Abstract

Homosyringaldehyde was isolated and identified from the 80% methanol extract of roots of Cynanchum paniculatum. C. paniculatum has been widely used for the treatment of various diseases such as neurasthenia, insomnia, dysmenorrheal and toothache. This compound exerted significant neuroprotective activities against glutamate-induced neurotoxicity in hippocampal HT22 cell line by 37.53% (at the concentration of $100{\mu}M$). We investigated mode of action of this compound. Homosyringaldehyde ($100{\mu}M$) significantly decreased the ROS level and $Ca^{2+}$ concentration in the oxidative stress induced HT22 cells by oxidative glutamate toxicity. Thus, our results suggest that homosyringaldehyde significantly protect HT22 cells against glutamate-induced oxidative stress, via antioxidative activities. As the results, we suggest that homosyringaldehyde may be useful in the treatment of neurogenerative disorders.

Keywords

References

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