Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-allergy Effect of Ethanol Extract from Duchesnea chrysantha

사매 에탄올 추출물의 항 알레르기 효과

  • Lee, Deok Jae (School of Alternative Medicine & Health Science, Jeonju University) ;
  • Cho, Il Young (School of Alternative Medicine & Health Science, Jeonju University) ;
  • Jang, Seon Il (Department of Health Science, Jeonju University)
  • 이덕재 (전주대학교 대체의학대학 대체건강관리학부) ;
  • 조일영 (전주대학교 대체의학대학 대체건강관리학부) ;
  • 장선일 (전주대학교 보건관리학과)
  • Received : 2012.09.26
  • Accepted : 2012.11.01
  • Published : 2012.12.25
Download PDF
⟨ Previous Next ⟩

Abstract

The worldwide prevalence and severity of allergic diseases including atopic dermatitis and asthma has increased dramatically over the past decade, especially in developed countries. Mast cells are important effector cells in allergic reactions. The purpose of this study was undertaken to investigate the anti-allergic activities of the extract of Duchesnea chrysantha (DCE). DCE was prepared by extracting with 80% ethanol. In the present study, we investigate the effect of DCE on the production of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$, IL-6, IL-8, and histamine in the human mast cell line (HMC-1 cells) and on the scratching behavior in hairless mice. Various concentrations of DCE were treated before the activation of HMC-1 cells with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. PMA plus A23187 significantly increased TNF-${\alpha}$, IL-$1{\beta}$, IL-6, and IL-8 production compared with media control. We also show that the increased cytokines such as TNF-${\alpha}$ IL-$1{\beta}$, IL-6, and IL-8 were significantly inhibited by DCE in a dose-dependent manner. Moreover, DCE inhibited the histamine release from HMC-1 cells stimulated by compound 48/80, which promotes histamine release. Futhermore, the administration of DCE reduced the scratching behavior induced by pruritogen (compound 48/80 or histamine) in hairless mice. These results suggest that DCE has a potential use as a medicinal plant for treatment against allergy-related disease.

Keywords

References

  1. Kay, A.B. Overview of allergy and allergic diseases: with a view to the future. Br Med Bull. 56: 843-864, 2000. https://doi.org/10.1258/0007142001903481
  2. Takai, T., Ikeda, S. Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases. Allergol Int. 60: 25-35, 2011. https://doi.org/10.2332/allergolint.10-RAI-0273
  3. Sperge,l J.M. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am. 30: 269-280, 2010. https://doi.org/10.1016/j.iac.2010.06.003
  4. Leung, D.Y., Boguniewicz, M., Howell, M.D., Nomura, I., Hamid, Q.A. New insights into atopic dermatitis. J Clin Invest. 113: 651-657, 2004. https://doi.org/10.1172/JCI21060
  5. Boguniewicz, M., Leung, D.Y. Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol. 125: 4-13, 2010. https://doi.org/10.1016/j.jaci.2009.11.027
  6. Nakae, S., Suto, H., Kakurai, M., Sedgwick, J.D., Tsai, M., Galli, S.J. Mast cells enhance T cell activation: importance of mast cell-derived TNF. Proc Natl Acad Sci USA. 102: 6467-6472, 2005. https://doi.org/10.1073/pnas.0501912102
  7. Galli, S.J. New concepts about the mast cell. N Engl J Med. 328, 257-265, 1993. https://doi.org/10.1056/NEJM199301283280408
  8. Mekori, Y.A., Metcalfe, D.D. Mast cells in innate immunity. Immunol Rev. 173: 131-140, 2000. https://doi.org/10.1034/j.1600-065X.2000.917305.x
  9. Gurish, M.F., Austen, K.F. The diverse roles of mast cells. J Exp Med. 194: F1-F5, 2001. https://doi.org/10.1084/jem.194.1.F1
  10. Kay, A.B. Allergy and allergic diseases. First of two parts. N Engl J Med. 344: 30-37 2001. https://doi.org/10.1056/NEJM200101043440106
  11. Hosoda, M., Yamaya, M., Suzuki, T., Yamada, N., Kamanakam, M., Sekizawa, K., Butterfield, J.H., Watanabe, T., Nishimura, H., Sasaki, H. Effects of rhinovirus infection on histamine and cytokine production by cell lines from human mast cells and basophils. J Immunol. 169: 1482-1491, 2002. https://doi.org/10.4049/jimmunol.169.3.1482
  12. Lee, I.R., Lee, E.B., Lee, S.H., Lee, J.Y. Biologically active components of Duchesnea indicae herba. Kor J Pharmacogn. 15: 85-90, 1984.
  13. Lee, I.R., Kim, Y.H., Jeong, G.J. Studies on the Pharmacological Actions and Biological Active Components of Korean Traditional Medicine -The Components of Antitumor and Antimicrobial Activity from Duchesnea indica. J Pharm Soci. 31: 230-235, 1987.
  14. Lee, I.R., Lee, Y.S., Han, Y.N. Studies on the pharmacological actions and biological active components of Korean traditional medicine (V)-Isolation of an antimicrobial phenolic compound from Duchesnea indica. Yakhak Hoeji. 132: 308-312, 1988.
  15. Kim, Y.K., Ryu, B.H., Kim, J.S., Yoon, S.H., Ryu, Y.K. Effects of Duchesnea indica on several kinds of cancer cells. Korean J Orient int Med. 26: 320-332, 2005.
  16. Kim, K.C., Kim, J.S., Son, J.K., Kim, I.G. Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts. Cancer Lett. 246: 210-217, 2007. https://doi.org/10.1016/j.canlet.2006.02.014
  17. Lee, I.R., Yang, M.Y. Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell. Arch Pharm Res. 17: 476-479, 1994. https://doi.org/10.1007/BF02979129
  18. Lee, J.S., Kim, I.S., Ryu. J.S., Kim, J.H., Kim, J.S., Kim, D.H., Yun, C.Y. The Inhibitory Effect of Duchesnea chrysantha Extract on the Development of Atopic Dermatitis-like Lesions by Regulating IgE and Cytokine Production in Nc/Nga Mice. Phytother Res. doi: 10.1002/ptr.3545, 2011.
  19. Yang, E.J., Lee, J.S., Yun, C.Y., Kim, J.H., Kim, J.S., Kim, D.H., Kim, I.S. Inhibitory effects of Duchesnea chrysantha extract on ovalbumin-induced lung inflammation in a mouse model of asthma. J Ethnopharmacol. 118: 102-107, 2008. https://doi.org/10.1016/j.jep.2008.03.012
  20. 이덕재, 전인화, 김현수, 조일영, 장선일. 사매 에탄올 추출물의 항산화 및 항염증 효과. 동의생리병리학회지 26: 59-66, 2012.
  21. Mihara,, K., Kuratani, K., Matsui, T., Nakamura, M., Yokota, K. Vital role of the itch-scratch response in development of spontaneous dermatitis in NC/Nga mice. Br J Dermato. 151: 335-345, 2004. https://doi.org/10.1111/j.1365-2133.2004.06036.x
  22. Hanifin, J.M., Cooper, K.D., Ho, V.C., Kang, S., Krafchik, B.R., Margolis, D.J., Schachner, L.A., Sidbury, R., Whitmore, S.E., Sieck, C.K., Van Voorhees, A.S. Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association "Administrative Regulations for Evidence-Based Clinical Practice Guidelines". J Am Acad Dermatol. 50: 391-404, 2004. https://doi.org/10.1016/j.jaad.2003.08.003
  23. Dinarello, C.A. The biological properties of interleukin-1. Eur Cytokine Netw. 5: 517-531, 1994.
  24. Walsh, L.J., Trinchieri, G., Waldorf, H.A., Whitaker, D., Murphy, G.F. Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci USA. 88: 4220-4224, 1991. https://doi.org/10.1073/pnas.88.10.4220
  25. Brzezinska-Blaszczyk, E., Misiak-Tloczek, A. The regulation of mast cell migration. Part 2: mast cell chemoattractants. Postepy Hig Med Dosw (Online). 28, 61:493-499, 2007.
  26. Jeong, H.J., Na, H.J., Kim, S.J., Rim, H.K., Myung, N.Y., Moon, P.D., Han, N.R., Seo, J.U., Kang, T.H., Kim, J.J., Choi, Y., Kang, I.C., Hong, S.H., Kim, Y.A., Seo, Y.W., Kim, H.M., Um, J.Y. Anti-inflammatory effect of Columbianetin on activated human mast cells. Biol Pharm Bull. 32: 1027-1031, 2009. https://doi.org/10.1248/bpb.32.1027