Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Saururus Chinensis in RANKL-induced Osteoclast Differentiation

삼백초 추출물이 뼈 파괴세포 분화에 미치는 효과

  • Kim, Jung Young (Department of Anatomy, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Hyuk, Jungjong (Department of Rheumatology, College of Medicine, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Lee, Myeung Su (Department of Anatomy, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Lee, Chang Hoon (Institute for Skeletal Disease, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Kim, Yun Kyung (Department of Oriental Pharmacy, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Jeon, Byung Hoon (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kwak, Han Bok (Department of Anatomy, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Kim, Ju-Young (Department of Anatomy, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Choi, Min-Kyu (Department of Anatomy, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Kim, Jeong Joong (Department of Anatomy, Wonkwang Oriental Medicines Research Institute, Wonkwang University) ;
  • Oh, Jaemin (Department of Anatomy, Wonkwang Oriental Medicines Research Institute, Wonkwang University)
  • 김정영 (원광대학교 의과대학 해부학교실) ;
  • 정종혁 (원광대학교 의과대학 류마티스내과학교실) ;
  • 이명수 (원광대학교 의과대학 해부학교실) ;
  • 이창훈 (원광대학교 의과대학 골격계질환연구소) ;
  • 김윤경 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실 및 한국전통의학연구소) ;
  • 곽한복 (원광대학교 의과대학 해부학교실) ;
  • 김주영 (원광대학교 의과대학 해부학교실) ;
  • 최민규 (원광대학교 의과대학 해부학교실) ;
  • 김정중 (원광대학교 의과대학 해부학교실) ;
  • 오재민 (원광대학교 의과대학 해부학교실)
  • Received : 2012.10.26
  • Accepted : 2012.12.05
  • Published : 2012.12.25
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Abstract

Balance between bone-forming osteoblasts and bone-resorbing osteoclasts is important in bone homeostasis. Unusual balance between bone-forming osteoblasts and bone-resorbing osteoclasts leads to bone diseases, such as osteoporosis. Saururus chinensis has been widely used in oriental medicine. Saururus chinensis has been known that has antioxidant and anticancer effect. But, the effect of Saururus chinensis in osteoclast differentation remains unknown. We examined the effect of Saururus chinensis in receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. From the results of our study, we found that saururus chinensis clearly inhibited RANKL-induced osteoclast differentiation in bone marrow macrophages (BMM) in a dose dependent manner without toxicity. Saururus chinensis inhibited the phosphorylation of JNK, P38, AKT, and ERK induced by RANKL. The mRNA expression of NFATc1, TRAP, and OSCAR induced by RANKL was inhibited by Saururus chinensis treatment. Moreover Saururus chinensis suppressed the protein expression of c-Fos and NFATc1 in BMMs treated with RANKL. These results suggest that Saururus chinensis may be a useful drug in the treatment of bone-related disease.

Keywords

Acknowledgement

Supported by : 원광대학교

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