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Pattern of Hepatitis A Incidence According to Area Characteristics Using National Health Insurance Data

  • Seo, Joo-Youn (Department of Preventive Medicine/Institute of Community Health, Hanyang University College of Medicine) ;
  • Seo, Jae-Hee (Department of Preventive Medicine/Institute of Community Health, Hanyang University College of Medicine) ;
  • Kim, Myoung-Hee (People's Health Institute) ;
  • Ki, Mo-Ran (Department of Preventive Medicine, Eulji University School of Medicine) ;
  • Park, Hee-Suk (Department of Preventive Medicine/Institute of Community Health, Hanyang University College of Medicine) ;
  • Choi, Bo-Youl (Department of Preventive Medicine/Institute of Community Health, Hanyang University College of Medicine)
  • Received : 2011.07.08
  • Accepted : 2011.10.10
  • Published : 2012.05.31

Abstract

Objectives: Over the past several years, the incidence of hepatitis A infection has been increasing rapidly in the young-adult population in Korea. We examined the effects of area-level socioeconomic status and environmental hygiene on the incidence of hepatitis A. Methods: This study is based on the registered national population of Korea and the national health insurance data from 2004 to 2008. A total of 73 459 individuals were confirmed to have had hepatitis A. The standardized incidences of hepatitis A in 232 districts adjusted for sex and age of people were calculated for each year, and the rate ratios of the incidence rates were estimated according to area-level socioeconomic status and environmental hygiene using multiple Poisson regression models. Results: The incidence rates of hepatitis A infection were 15.6 (per 100 000) in 2004, 19.0 (per 100 000) in 2005, 27.2 (per 100 000) in 2006, 25.1 (per 100 000) in 2007, and 61.7 (per 100 000) in 2008. The analysis of the area-level effects showed that residential areas of the less deprived than other regions, areas with higher levels of education, and heavily populated areas were significantly associated with increased risk. Conclusions: There is a very strong possibility that both area-level socioeconomic status and environmental hygiene play a role in increasing the risk of hepatitis A infection in Korea. Therefore, to reduce hepatitis A infection, we need a nationwide strategy that considers these area-level characteristics.

Keywords

References

  1. Kang HM, Jeong SH, Kim JW, Lee D, Choi CK, Park YS, et al. Recent etiology and clinical features of acute viral hepatitis in a single center of Korea. Korean J Hepatol 2007;13(4):495-502 (Korean).
  2. Park SH. Hepatitis A: past and present. J Korean Med Assoc 2009;52(10):996-1004 (Korean).
  3. Eun JR, Lee HJ, Kim TN, Jang BI, Moon HJ. Clinical characteristics of adult patients with acute hepatitis A. Yeungnam Univ J Med 2007;24(2):170-178 (Korean).
  4. Jung YK, Kim JH. Epidemiology and clinical features of acute hepatitis A: from the domestic perspective. Korean J Hepatol 2009;15(4):438-445 (Korean).
  5. Kim JH. Recent epidemiological status and vaccination of hepatitis A in Korea. J Korean Med Assoc 2008;51(2):110- 118 (Korean).
  6. Park JH. Changes in the seroprevalence of hepatitis A virus antibody in Korea. Korean J Hepatol 2007;13(1):1-4 (Korean).
  7. Jeong SH. Current status and vaccine indication for hepatitis A virus infection in Korea. Korean J Gastroenterol 2008;51(6):331-337 (Korean).
  8. Jacobsen KH, Koopman JS. The effects of socioeconomic development on worldwide hepatitis A virus seroprevalence patterns. Int J Epidemiol 2005;34(3):600-609.
  9. Jacobsen KH, Koopman JS. Declining hepatitis A seroprevalence: a global review and analysis. Epidemiol Infect 2004;132(6):1005-1022.
  10. Song YB, Lee JH, Choi MS, Koh KC, Paik SW, Yoo BC, et al. The age-specific seroprevalence of hepatitis A virus antibody in Korea. Korean J Hepatol 2007;13(1):27-33 (Korean).
  11. De Alencar Ximenes RA, Martelli CM, Merchan-Hamann E, Montarroyos UR, Braga MC, de Lima ML, et al. Multilevel analysis of hepatitis A infection in children and adolescents: a household survey in the Northeast and Central-west regions of Brazil. Int J Epidemiol 2008;37(4):852-861.
  12. Kim DK, Kim YD, Jang HO, Jo JR. Prevalence of hepatitis A IgG antibody in children and adolescents in Gyeonggi province. Inje Med J 2006;27:53-58 (Korean).
  13. Kim TY, Sohn JH, Ahn SB, Son BK, Lee HL, Eun CS, et al. Comparison of recent IgG anti-HAV prevalence between two hospitals in Seoul and Gyeonggi area. Korean J Hepatol 2007;13(3):363-369 (Korean).
  14. Choi W, Eom HS, Kim IH, Lee DH, Kim PS, Kim HG, et al. Patterns of acute hepatitis A and anti-HAV seroprevalence of Kyungin province. Korean J Gastroenterol 1999;34(1):69-75 (Korean).
  15. Management Center for Health Promotion, Hanyang University. Health promotion strategies and programmes development for health inequalities alleviation. Seoul: Ministry of Health & Welfare; 2009, p. 227-303 (Korean).
  16. Korea Statistical Information Service. Domestic statistics classified by subjects [cited 2012 Apr 30]. Available from: http://kosis.kr/abroad/abroad_01List.jsp (Korean).
  17. Ministry of Public Administration and Security. Statistical year book of local government 2008. Seoul: Ministry of Public Administration and Security; 2009 (Korean).
  18. Han JY, Na BJ, Lee MS, Hong JY, Lim NG. The relationship between local fiscal indices and standardized mortality rate. Proceedings of the KAIS Spring Conference; 2010 May 28-29; Cheonan, Korea. Seoul: Korea Academia-Industrial Cooperation Society; 2010, p. 1072- 1076 (Korean).
  19. Ki MR, Choi BY. Economic analysis of vaccination and development of guidelines for control of hepatitis A virus infection, and epidemiologic analysis and development of control strategy of hepatitis C virus infection. Seoul: Korea Centers for Disease Control and Prevention; 2009, p. 38-41 (Korean).
  20. Szklo M, Nieto FJ. Stratification and adjustment: multivariate analysis in epidemiology. In: Szklo M, Nieto FJ. Epidemiology: beyond the basics. 2nd ed. Sudbury: Jones and Bartlett Publishers; 2007, p. 246-281.
  21. Park SK, Cheong HK, Ki M, Son YM, Kim H. Assessment of the availability of health insurance data for epidemiologic study of childhood aseptic meningitis. Korean J Prev Med 2003;36(4):349-358 (Korean).
  22. Tsai CF, Lin DB, Chen SC, Chang YH, Chen CY, Lin JB. Seroepidemiology of hepatitis A virus infection among schoolchildren in Taiwan. J Med Virol 2011;83(2):196-200.
  23. Choi HJ, Lee SY, Ma SH, Kim JH, Hur JH, Kang JH. Age related prevalence of antibodies to hepatitis A virus: performed in Korea in 2005. Korean J Pediatr Infect Dis 2005;12(2):186-194 (Korean).
  24. Kwon YO, Choi IJ, Jung JW, Park JH. An epidemiologic study on the seropositive rate of hepatitis A virus among a selected group of children and adults in Busan. Korean J Pediatr 2007;50(3):262-267 (Korean).
  25. Venczel L, Brown S, Frumkin H, Simmonds-Diaz J, Deitchman S, Bell BP. Prevalence of hepatitis A virus infection among sewage workers in Georgia. Am J Ind Med 2003;43(2):172-178.
  26. Tosti ME, Spada E, Romano L, Zanetti A, Mele A; SEIEVA collaborating group. Acute hepatitis A in Italy: incidence, risk factors and preventive measures. J Viral Hepat 2008;15(Suppl) 2:26-32.
  27. Korea Centers for Disease Control and Prevention. Epidemiology and control of vaccination targeted infectious disease. Cheongwon: Korea Centers for Disease Control and Prevention; 2010, p. 341-349 (Korean).
  28. Koslap-Petraco MB, Shub M, Judelsohn R. Hepatitis A: disease burden and current childhood vaccination strategies in the United States. J Pediatr Health Care 2008;22(1):3-11.
  29. Chodick G, Shalev V. Declining incidence of hepatitis A. JAMA 2006;295(3):282.

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