Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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Circadian Rhythm of ADH, Hypercalciuria, and Solute Diuresis as Pathogenesis of Enuresis

야뇨증의 병인 기전 -항이뇨호르몬, 고칼슘뇨증, 용질성 이뇨

  • Kang, Hee-Gyung (Department of Pediatrics, Seoul National University Children's Hospital)
  • 강희경 (서울대학교병원 소아청소년과)
  • Received : 2012.03.19
  • Accepted : 2012.04.07
  • Published : 2012.04.30
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Abstract

Nocturnal polyuria is one of the main pathogenic mechanisms of enuresis. Disturbance of circadian rhythm of antidiuretic hormone (ADH or AVP), hypercalciuria, and/or solute diuresis are considered to cause nocturnal polyuria, which in turn causes enuresis in patients with relatively small bladder capacity and high threshold for awakening. Evaluation of these factors would guide the therapeutic approach for enuresis.

야간 다뇨는 야뇨증의 중요한 원인 중 하나로 거론된다. 소변 양을 조절하는 항이뇨호르몬의 일중 변동의 부적절한 조절, 고칼슘뇨증, 용질 이뇨가 야간 다뇨의 원인으로 생각되며, 이러한 기전들로 야간의 소변량이 많은 환자에서 방광용적이 상대적으로 작고 잠에서 깨어나기 어려운 경우 야뇨증이 발생한다. 야뇨증 환자에서 이러한 요인들을 평가하여 개개인에게 적절한 치료를 도입하여야 할 것이다.

Keywords

References

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