대한본초학회지 (The Korea Journal of Herbology)

  • 제27권3호
  • /
  • Pages.39-55
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  • 2012
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
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한약의 다양한 항암기전

The various mechanisms of Korean traditional medicines for anti-cancer

  • 박영철 (대구가톨릭대학교 GLP 센터) ;
  • 박용기 (동국대학교 한의과대학 본초학교실) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Park, Yeong-Chul (GLP Center, Catholic University of Daegu) ;
  • Park, Yong-Ki (Dept. of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sangji University)
  • 투고 : 2012.04.16
  • 심사 : 2012.04.26
  • 발행 : 2012.05.30
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초록

Objectives : Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of herbal medicine. This paper was aimed to review herbal medicine playing its anticancer role in terms of apoptosis, inflammation control, differentiation and telomerase. Methods : New studies for tang, medicinal herb itself or effective ingradients of medicinal herb showing anti-cancer effectiveness were reviewed and summarized in terms of pharmacological action. Results : Ethanol extracts of $Spatholobus$ $suberectus$ greatly inhibited cancer cell growth inducing cell apoptosis and cytotoxic effects. $Scutellaria$ $baicalensis$ may be responsible for its anticancer activity showing inhibition of $PGE_2$ synthesis via suppression of COX-2 expression. Saikosaponins isolated from $Bupleurum$ induced the differentiation of C6 glioma cells, cancer cells, into astrocytes, normal cells. Acetone extract of $Bupleurum$ $scorzonerifolium$ inhibited proliferation of human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Conclusions : Herbal medicine inhibited cancer cell growth inducing cell apoptosis and cytotoxic effects. Inflammation persisting for a decade eventually elevates the risk of cancer sufficiently that it is discernible in case control epidemiological studies. Differentiation therapy is defined as a therapy to treat cancers by inducing differentiation of the stem cells. Telomerase expression is a hallmark of cancer. Nearly the complete spectrum of human tumors has been shown to be telomerase positive.

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