The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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The various mechanisms of Korean traditional medicines for anti-cancer

한약의 다양한 항암기전

  • Park, Yeong-Chul (GLP Center, Catholic University of Daegu) ;
  • Park, Yong-Ki (Dept. of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Lee, Sun-Dong (Dept. of Preventive medicine, School of Oriental Medicine, Sangji University)
  • 박영철 (대구가톨릭대학교 GLP 센터) ;
  • 박용기 (동국대학교 한의과대학 본초학교실) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2012.04.16
  • Accepted : 2012.04.26
  • Published : 2012.05.30
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Abstract

Objectives : Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of herbal medicine. This paper was aimed to review herbal medicine playing its anticancer role in terms of apoptosis, inflammation control, differentiation and telomerase. Methods : New studies for tang, medicinal herb itself or effective ingradients of medicinal herb showing anti-cancer effectiveness were reviewed and summarized in terms of pharmacological action. Results : Ethanol extracts of $Spatholobus$ $suberectus$ greatly inhibited cancer cell growth inducing cell apoptosis and cytotoxic effects. $Scutellaria$ $baicalensis$ may be responsible for its anticancer activity showing inhibition of $PGE_2$ synthesis via suppression of COX-2 expression. Saikosaponins isolated from $Bupleurum$ induced the differentiation of C6 glioma cells, cancer cells, into astrocytes, normal cells. Acetone extract of $Bupleurum$ $scorzonerifolium$ inhibited proliferation of human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Conclusions : Herbal medicine inhibited cancer cell growth inducing cell apoptosis and cytotoxic effects. Inflammation persisting for a decade eventually elevates the risk of cancer sufficiently that it is discernible in case control epidemiological studies. Differentiation therapy is defined as a therapy to treat cancers by inducing differentiation of the stem cells. Telomerase expression is a hallmark of cancer. Nearly the complete spectrum of human tumors has been shown to be telomerase positive.

Keywords

References

  1. American Cancer Society. "The History of Cancer". September 2009.
  2. Li XJ, Zhang HY. Western-medicine-validated anti-tumor agents and traditional Chinese medicine. Trends Mol Med. 2007 ;.14(1) : 1-2.
  3. Kessler RC, Davis RB, Foster DF, van Rompay MI, Walters EE, Wilkey SA, et al. Long-term trends in the use of complementary and alternative medical therapies in the United States. Ann Intern Med. 2001 ; 135(4) : 262-268. https://doi.org/10.7326/0003-4819-135-4-200108210-00011
  4. Dobos GJ, Tan L, Cohen MH, McIntyre M, Bauer R, Li X, et al. Are national quality standards for traditional Chinese herbal medicine sufficient?: Current governmental regulations for traditional Chinese herbal medicine in certain Western countries and China as the Eastern origin country. Complement Ther Med. 2005 ; 13(3) : 183-190. https://doi.org/10.1016/j.ctim.2005.06.004
  5. RUAN WJ, LAI MD, ZHOU JG. Anticancer effects of Chinese herbal medicine, science or myth? J Zhejiang Univ Science B. 2006 ; 7(12) : 1006-1014. https://doi.org/10.1631/jzus.2006.B1006
  6. Majno G. Joris I. Apoptosis, oncosis and necrosis: an overview of cell death. Am J Pathol. 1995 ; 146 : 3-15.
  7. Park YC. The molecular-biochemical principles of toxicology. KSI Co. 2010 ; ISBN 978-89-268-1259-4.
  8. Yang J, Xu ZP, Huang Y, Hope E. Hamrick, Penelope J. Duerksen-Hughes, Ying-Nian Y. ATM and ATR: Sensing DNA damage, World J Gastroenterol. 2004 ; 10(2) : 155-160. https://doi.org/10.3748/wjg.v10.i2.155
  9. Wang ZY, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LW, Guan XY, Chen JP. Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. J Ethnopharmacol. 2011 ; 133 : 751-758. https://doi.org/10.1016/j.jep.2010.11.004
  10. Dickson MA, Schwartz GK. Development of cell cycle inhibitors for cancer therapy. Curr Oncol. 2009 ; 16 : 36-43.
  11. Li J, Yuan J. Caspases in apoptosis and beyond. Oncogene. 2008 ; 27 : 6194-6206. https://doi.org/10.1038/onc.2008.297
  12. Suen DF, Norris KL, Youle RJ. Mitochondrial dynamics and apoptosis. Genes & Development. 2008 ; 22 : 1577-1590. https://doi.org/10.1101/gad.1658508
  13. Liu CY, Lee CF, Wei YH. Role of reactive oxygen species-elicited apoptosis in the pathophysiology of mitochondrial and neuro degenerative diseases associated with mitochondrial DNA mutations. J Formos Med Assoc. 2009 ; 108 : 599-611. https://doi.org/10.1016/S0929-6646(09)60380-6
  14. Lian Z, Niwa K, Gao J, Tagami K, Mori H, Tamaya T. Association of cellular apoptosis with anti-tumor effects of the Chinese herbal complex in endocrine-resistant cancer cell line. Cancer Detect Prev. 2003 ; 27 : 147-154. https://doi.org/10.1016/S0361-090X(03)00026-6
  15. Fitzpatrick, FA. Inflammation, carcinogenesis and cancer. International Immunopharmacology. 2001 ; 1 : 1651-1667. https://doi.org/10.1016/S1567-5769(01)00102-3
  16. Morson BC. Precancer and cancer in inflammatory bowel disease. Pathology. 1985 ; 17 : 173-80. https://doi.org/10.3109/00313028509063753
  17. Vesterinen E, Pukkala E, Timonen T, Aromaa A. Cancer incidence among 78,000 asthma patients. Int J Epidemiol. 1993 ; 22 : 976-82. https://doi.org/10.1093/ije/22.6.976
  18. Ekbom A, Helmnick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer, a population based study. N Engl J Med. 1990 ; 323 : 1228-33. https://doi.org/10.1056/NEJM199011013231802
  19. Lashner BA. Colorectal cancer in ulcerative colitis patients: survival curves and surveillance. Cleveland Clin J Med. 1994 ; 61 : 272-275. https://doi.org/10.3949/ccjm.61.4.272
  20. Aarnio M, Mustonen H, Mecklin JP, Jarvinen HJ. Prognosis of colorectal cancer varies in different high risk conditions. Ann Med. 1998 ; 30 : 75-80. https://doi.org/10.3109/07853899808999387
  21. Ekbom A, Helmick CG, Zack M, Holmberg L, Adami HO. Survival and causes of deaths in patients with inflammatory bowel disease: a population based study. Gastroenterology. 1992 ; 103 : 954-960. https://doi.org/10.1016/0016-5085(92)90029-X
  22. Singer II, Kawka DW, Schloemann S, Tessner T, Riehl T, Stenson WF. Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. Gastroenterology. 1998 ; 115 : 297-306. https://doi.org/10.1016/S0016-5085(98)70196-9
  23. Agoff SN, Brentnall TA, Crispin DA, Taylor SL, Raaka S, Haggitt RC, et al. The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. Am J Pathol. 2000 ; 157(3) : 737-745. https://doi.org/10.1016/S0002-9440(10)64587-7
  24. Vesterinen E, Pukkala E, Timonen T, Aromaa A. Cancer incidence among 78,000 asthma patients. Int J Epidemiol. 1993 ; 22 : 976-82. https://doi.org/10.1093/ije/22.6.976
  25. Huovinen E, Kaprio J, Vesterinen E, Koskenvuo M. Mortality of adults with asthma: a prospective cohort study. Thorax. 1997 ; 52 : 49-54. https://doi.org/10.1136/thx.52.1.49
  26. Kallen B, Gunnarskog J, Conradson TB. Cancer risk in asthmatic subjects selected from hospital discharge registry. Eur Respir J. 1993 ; 6 : 694- 697.
  27. Askling J, Grunewald J, Eklund A, Hillerdal G, Ekbom A. Increased risk for cancer following sarcoidosis. Am J Respir Crit Care Med. 1999 ; 160(5 Pt 1) : 1668-1672. https://doi.org/10.1164/ajrccm.160.5.9904045
  28. Rosin MP, Anwar WA, Ward AJ. Inflammation, chromosomal instability, and cancer: the schistosomiasis model. Cancer Res. 1994 ; 54(7 Suppl) : 1929S-1933S.
  29. Burin GJ, Gibb HJ, Hill RN. Human bladder cancer: evidence for a potential irritation-induced mechanism. Food Chem Toxicol. 1995 ; 33 : 785-795. https://doi.org/10.1016/0278-6915(95)00045-4
  30. Persky L. Epidemiology of cancer of the penis. Recent Results Cancer Res. 1977 ; 60 : 97-109. https://doi.org/10.1007/978-3-642-81095-4_11
  31. Carlson JA, Ambros R, Malfetano J, Ross J, Grabowski R, Lamb P, et al. Vulvar lichen sclerosus and squamous cell carcinoma: a cohort, case control, and investigational study with historical perspective: implications for chronic inflammation and sclerosis in the development of neoplasia. Hum Pathol. 1998 ; 29 : 932-948. https://doi.org/10.1016/S0046-8177(98)90198-8
  32. Mayron R, Grimwood RE, Siegle RJ, Camisa C. Verrucous carcinoma arising in ulcerative lichen planus of the soles. J Dermatol Surg Oncol. 1988 ; 14 : 547-551. https://doi.org/10.1111/j.1524-4725.1988.tb01150.x
  33. Schildkraut JM, Bastos E, Berchuk A. Relationship between lifetime ovarian cycles and overexpression of mutant p53 in epithelial ovarian cancer. J Natl Cancer Inst. 1997 ; 89 : 932-938. https://doi.org/10.1093/jnci/89.13.932
  34. Kern SE. Molecular genetic alterations in ductal pancreatic adenocarcinomas. Med Clin North Am. 2000 ; 84 : 691-695. https://doi.org/10.1016/S0025-7125(05)70251-0
  35. Coogan PF, Rosenberg L, Louik C, Zauber AG, Stolley PD, Strom BL, et al. NSAIDs and risk of colorectal cancer according to presence or absence of family history of the disease. Cancer Causes Control. 2000 ; 11(3) : 249-255. https://doi.org/10.1023/A:1008931708716
  36. Lewis JG, Adams DO. Inflammation, oxidative DNA damage, and carcinogenesis. Environ Health Perspect. 1987 ; 76 : 19-27. https://doi.org/10.1289/ehp.877619
  37. Jackson JH, Gajewski E, Schraufstatter IU, Hyslop PA, Fuciarelli AF, Cochrane CG, et al. Damage to the bases in DNA induced by stimulated human neutrophils. J Clin Invest. 1989 ; 84(5) : 1644-1649. https://doi.org/10.1172/JCI114342
  38. Weitzman SA, Weitberg AB, Clark EP. Stossel TP. Phagocytes as carcinogens: malignant transformation produced by human neutrophils. Science. 1985 ; 227(4691) : 1231-1233. https://doi.org/10.1126/science.3975611
  39. Weitzman SA, Gordon LI. Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood. 1990 ; 76(4) : 655-663.
  40. Fu JY, Masferrer JL, Seibert K, Raz A, Needleman P. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J Biol Chem. 1990 ; 265 : 16737-16740.
  41. Lipsky PE, Abramson SB, Breedveld FC, Brook P, Burmester R, Buttgereit F, et al. Analysis of the effect of COX-2 specific inhibitors and recommendations for their use in clinical practice. J Rheumatol. 2000 ; 27 : 1338-1340.
  42. Chung FL, Nath RG, Ocando J, Nishikawa A, Zhang L. Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources. Cancer Res. 2000 ; 60 : 1507-1511.
  43. Surette ME, Fonteh AN, Bernatchez C, Chilton FH. Perturbations in the control of cellular arachidonic acid levels block cell growth and induce apoptosis in HL-60 cells. Carcinogenesis. 1999 ; 20 : 757-763. https://doi.org/10.1093/carcin/20.5.757
  44. Hainaut P, Hollstein M. p53 and human cancer: the first ten thousand mutations. Adv Cancer Res. 2000 ; 77 : 81-137.
  45. Ozturk Mehmet, Ayca Arslan-Ergul, Sevgi Bagislar, Serif Senturk, Haluk Yuzugullu. Senescence and immortality in hepatocellular carcinoma. Cancer Letters. 2009 ; 286 : 103-113. https://doi.org/10.1016/j.canlet.2008.10.048
  46. Schildkraut JM, Bastos E, Berchuk A. Relationship between lifetime ovarian cycles and overexpression of mutant p53 in epithelial ovarian cancer. J Natl Cancer Inst. 1997 ; 89 : 932-938. https://doi.org/10.1093/jnci/89.13.932
  47. Moos PJ, Edes K, Fitzpatrick FA. Inactivation of the wild type p53 tumor supprerssor by electrophilic prostaglandins. Proc Natl Acad Sci USA. 2000 ; 97(16) : 9215-9220. https://doi.org/10.1073/pnas.160241897
  48. Zhang, David Y, Josephine Wu, Fei Ye, et al. Inhibition of Cancer Cell Proliferation and Prostaglandin E2 Synthesis by Scutellaria Baicalensis. Cancer Res. 2003 ; 63 : 4037-4043.
  49. Arey LB. Developmental anatomy: a textbook and laboratory manual of embryology. 7th ed. London : WB Saunders Co. 1974 : 58-70.
  50. Sherley JL. Asymmetric cell kinetics genes: the key to expansion of adult stem cells in culture. Stem Cells. 2002 ; 20 : 561-572. https://doi.org/10.1634/stemcells.20-6-561
  51. Sell S. Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol. 2004 ; 51 : 1-28. https://doi.org/10.1016/j.critrevonc.2004.04.007
  52. Pierce GB, Shikes R, Fink LM. Cancer: a problem of developmental biology. Englewood Cliffs NJ : Prentice-Hall Inc. 1978 ; 242.
  53. Scott RE. Differentiation, Differentiation/Gene Therapy and Cance. Pharmacol Ther. 1997 ; 73(1) : 51-65. https://doi.org/10.1016/S0163-7258(96)00120-9
  54. Yuspa SH. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogcncsis- Thirty-third G H. A. Clowes Memorial Award Lecture. Cancer Res. 1994 ; 54 : 1178-1189.
  55. Garder RL. Extrinsic factors in cellular differentiation. Int J Dev Biol. 1993 ; 37 : 47-50.
  56. Yen A, Roberson MS, Varvayanis, S, & Lee AT. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signalregulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res. 1998 ; 58 : 3163-3172.
  57. Kiyokawa, H, Richon, VM, Venta-Perez, G, Rifkind, RA, & Marks, PA. Hexamethylenebisacetamide-induced erythroleukemia cell differentiation involves modulation of events required for cell cycle progression through G1. Proc Natl Acad Sci USA 1993 ; 90 ; 6746- 6750. https://doi.org/10.1073/pnas.90.14.6746
  58. Tsai YJ, Chen IL, Horng LY, Wu RT. Induction of Differentiation in Rat C6 Glioma Cells with Saikosaponins. Phytother Res. 2002 ; 16 : 117-121. https://doi.org/10.1002/ptr.752
  59. Park HJ, Han ES, Park DK. The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis. J Ethnopharmacol. 2010 ; 132 : 115-121. https://doi.org/10.1016/j.jep.2010.07.052
  60. Moyzis RK, Buckingham JM, Cram LS, et al. A highly conserved repetitive DNA sequence (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA. 1988 ; 85 : 6622-6626. https://doi.org/10.1073/pnas.85.18.6622
  61. Griffith JD, Comeau L, Rosenfield S, et al. Mammalian telomeres end in a large duplex loop. Cell 1999 ; 97 : 503-514. https://doi.org/10.1016/S0092-8674(00)80760-6
  62. Shay JW, Wright WE. Hayflick, his limit, and cellular ageing. Nature Rev Mol Cell Biol. 2000 ; 1 : 72-76. https://doi.org/10.1038/35036093
  63. Wright WE, Shay JW. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr Opin Genet Dev. 2001 ; 11 : 98-103. https://doi.org/10.1016/S0959-437X(00)00163-5
  64. Meyerson M. Role of telomerase in normal and cancer cells. J Clin Oncol. 2000 ; 18 : 2626-2634. https://doi.org/10.1200/JCO.2000.18.13.2626
  65. Granger MP, Wright WE, Shay JW. Telomerase in cancer and aging. Crit Rev Oncol Hematol. 2002 ; 41 : 29-40. https://doi.org/10.1016/S1040-8428(01)00188-3
  66. Cohen SB, et al. Protein composition of catalytically active human telomerase from immortal cells. Science. 2007 ; 315(5820) : 1850-1853. https://doi.org/10.1126/science.1138596
  67. Wang E, Lee MJ, Pandey S. Control of fibroblast senescence and activation of programmed cell death. J Cell Biochem. 1994 ; 54 : 432-439. https://doi.org/10.1002/jcb.240540410
  68. Zaffaroni N, Lualdi S, Villa R, Bellarosa D, Cermele C, Felicetti P, Rossi C, Orlandi L, Daidone MG. Inhibition of telomerase activity by a distamycin derivative: effects on cell proliferation and induction of apoptosis in human cancer cells. Eur J Cancer. 2002 ; 38(13) : 1792-801. https://doi.org/10.1016/S0959-8049(02)00139-9
  69. Park SE, Yoo HS, Jin CY, Hong SH, Lee YW, Kim BW, Lee SH, Kim WJ, Cho CK, Choi YH. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food and Chem Toxicol. 2009 ; 47 : 1667-1675. https://doi.org/10.1016/j.fct.2009.04.014
  70. Loo, TY, JP Chen, Louis WC Chow, Jeffrey WK, Chou. Effects of Shugansanjie Tang on matrix metalloproteinases 1, 3 and 9 and telomerase reverse transcriptase expression in human breast cells in vitro. Biomed Pharmacother. 2007 ; 61 : 601-605. https://doi.org/10.1016/j.biopha.2007.08.024
  71. Park DI, Lee JH, Moon SK, Kim CH, Lee YT, Cheong JH, Choi BT, Choi YH. Induction of apoptosis and inhibition of telomerase activity by aqueous extract from Platycodon grandiflorum in human lung carcinoma cells. Pharmacol Res. 2005 ; 51 : 437-443. https://doi.org/10.1016/j.phrs.2004.11.003
  72. Park, SE, Park, C, Kim, SH, Hossain, MA, Kim, MY, Chung, HY, Son, WS, Kim, GY, Choi, YH, Kim, ND. Korean red ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells. J Ethnopharmacol. 2009 ; 121 : 304-312. https://doi.org/10.1016/j.jep.2008.10.038

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