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The effects of $Angelica$ $keiskei$ $Koidz$ on the expression of antioxidant enzymes related to lipid profiles in rats fed a high fat diet

  • Received : 2011.10.06
  • Accepted : 2012.12.29
  • Published : 2012.02.29

Abstract

This study was performed to examine the feeding effects of $Angelica$ $keiskei$ $Koidz$ (AK) and its processed products on serum, liver, and body fat content and the expression of antioxidant genes in rats fed a high fat diet. AK and its processed products were added at 3-5% to a high fat diet and fed to adult rats for 6 weeks. In experiment 1 (EXP 1), the rats were fed with one of six diets including a control diet (normal fat), high fat diet (HF), and HF + AK additives groups (four groups). In experiment 2 (EXP 2), the rats were separated into three groups of HF, HF + AK whole leaves, and HF + fermented juice (FS) + squeeze (SA). Body weight was not different among the groups in either experiment. The liver weight was lower in the FS and SA groups compared to that in the other groups (P<0.05). Serum luteolin was higher in the AK and processed products groups compared to that in the HF group (P<0.05). Gene expression of the antioxidative enzymes catalase and glutathione-s-reductase in the liver was higher in the AK processed products group than that in the other groups (P<0.05). The results suggest that the intake of AK and its processed products increased the expression of antioxidant enzymes in animals fed a high fat diet, reduced hepatic cholesterol content, and increased the effective absorption of luteolin.

Keywords

References

  1. Kozawa M, Morita N, Baba K, Hata K. Chemical components of the roots of Angelica keiskei Koidzumi. II. The structure of the chalcone derivatives. Yakugaku Zasshi 1978;98:210-4. https://doi.org/10.1248/yakushi1947.98.2_210
  2. Kim OK, Kung SS, Park WB, Lee MW, Ham SS. The nutritional components of aerial whole plant and juice of Angelica keiskei Koidz. Korean J Food Sci Technol 1992;24:592-6.
  3. Mitsuhashi H. Illustrated Medicinal Plants of the World in Colour. Tokyo: Hokuryukan; 1988. p.350.
  4. Eyre H, Kahn R, Robertson RM; ACS/ADA/AHA Collaborative Writing Committee. Preventing cancer, cardiovascular disease, and diabetes: a common agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association. CA Cancer J Clin 2004;54:190-207. https://doi.org/10.3322/canjclin.54.4.190
  5. Hirayama T. Nutrition and cancer - a large scale cohort study. In: Knudsen I, editor. Genetic Toxicology of the Diet. New York: Liss Inc.; 1986. p.94.
  6. Neuhouser ML. Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer 2004;50:1-7. https://doi.org/10.1207/s15327914nc5001_1
  7. Mojzisová G, Kuchta M. Dietary flavonoids and risk of coronary heart disease. Physiol Res 2001;50:529-35.
  8. Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002;22:19-34. https://doi.org/10.1146/annurev.nutr.22.111401.144957
  9. Birt DF, Hendrich S, Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 2001;90:157-77. https://doi.org/10.1016/S0163-7258(01)00137-1
  10. Lopez-Lazaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 2009;9:31-59. https://doi.org/10.2174/138955709787001712
  11. Kim SH, Shin KJ, Kim D, Kim YH, Han MS, Lee TG, Kim E, Ryu SH, Suh PG. Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts. Biochem Pharmacol 2003;66:955-63. https://doi.org/10.1016/S0006-2952(03)00465-9
  12. Kotanidou A, Xagorari A, Bagli E, Kitsanta P, Fotsis T, Papapetropoulos A, Roussos C. Luteolin reduces lipopolysaccharideinduced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med 2002;165:818-23. https://doi.org/10.1164/ajrccm.165.6.2101049
  13. Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer 2007;121: 2225-32. https://doi.org/10.1002/ijc.22790
  14. Zhu X, Zhang H, Lo R. Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities. J Agric Food Chem 2004;52:7272-8. https://doi.org/10.1021/jf0490192
  15. Ichimura T, Yamanaka A, Ichiba T, Toyokawa T, Kamada Y, Tamamura T, Maruyama S. Antihypertensive effect of an extract of Passiflora edulis rind in spontaneously hypertensive rats. Biosci Biotechnol Biochem 2006;70:718-21. https://doi.org/10.1271/bbb.70.718
  16. Institute of Laboratory Animal Resources. Guide for the Care and Use of Laboratory Animals. Washington, D.C.: National Academy Press; 1996. p.21-55.
  17. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18:499-502.
  18. Shimoi K, Okada H, Furugori M, Goda T, Takase S, Suzuki M, Hara Y, Yamamoto H, Kinae N. Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Lett 1998;438:220-4. https://doi.org/10.1016/S0014-5793(98)01304-0
  19. Zhou P, Li LP, Luo SQ, Jiang HD, Zeng S. Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin. J Agric Food Chem 2008;56: 296-300. https://doi.org/10.1021/jf072612+
  20. King RA, Broadbent JL, Head RJ. Absorption and excretion of the soy isoflavone genistein in rats. J Nutr 1996;126:176-82. https://doi.org/10.1093/jn/126.1.176
  21. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
  22. Le Lay S, Lefrere I, Trautwein C, Dugail I, Krief S. Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target. J Biol Chem 2002;277:35625-34. https://doi.org/10.1074/jbc.M203913200

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