Archives of Plastic Surgery

  • 제39권5호
  • /
  • Pages.457-462
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  • 2012
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
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A Skin Fixation Method for Decreasing the Influence of Wound Contraction on Wound Healing in a Rat Model

  • Bae, Seong Hwan (Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine) ;
  • Bae, Yong Chan (Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine) ;
  • Nam, Su Bong (Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine) ;
  • Choi, Soo Jong (Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine)
  • 투고 : 2012.07.10
  • 심사 : 2012.08.22
  • 발행 : 2012.09.15
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초록

Background The elasticity of the back skin of the rat reduced the tension around wounds during the wound healing process in that region, and thus activates wound contraction. The authors proposed two skin fixation methods using readily available materials to decrease the influence of wound contraction on wound healing and designed an experiment to determine their effects. Methods The authors made 36 skin wounds on the backs of 18 rats, and they divided them into three groups. Each group was treated with three different kinds of dressing materials, each with different skin fixing characteristics. Group A was a control group. Group B and group C were dressed by the first and the second skin fixation method. We measured the areas of the wounds post-surgically and calculated the wound area reduction rates. Results The two skin fixation methods both reduced the effect of wound contraction compared to the control group. Each of the two methods had different outcomes in reducing wound contraction. Conclusions The experiment demonstrated significant differences among the wound areas and the wound area reduction rates of the three groups as a result of differences in the degree of wound contraction. To obtain accurate results from wound healing experiments, appropriate skin fixation methods must be adopted.

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참고문헌

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피인용 문헌

  1. Cell Therapy for Wound Healing vol.29, pp.3, 2012, https://doi.org/10.3346/jkms.2014.29.3.311
  2. Overview of Surgical Scar Prevention and Management vol.29, pp.6, 2012, https://doi.org/10.3346/jkms.2014.29.6.751
  3. Static Langer's line and wound contraction rates according to anatomical regions in a porcine model vol.22, pp.5, 2012, https://doi.org/10.1111/wrr.12206
  4. Effect of high- and low- frequency transcutaneous electrical nerve stimulation (TENS) on angiogenesis and wound contraction in acute excisional wounds in rat skin vol.30, pp.4, 2012, https://doi.org/10.1590/1980-5918.030.004.ao02
  5. Haemodynamically stimulated and in vivo generated axially vascularized soft‐tissue free flaps for closure of complex defects: Evaluation in a small animal model vol.12, pp.3, 2012, https://doi.org/10.1002/term.2477
  6. Effects of Plantago lanceolata L. extract on full-thickness excisional wound healing in a mouse model vol.93, pp.4, 2018, https://doi.org/10.1080/10520295.2017.1421773
  7. Bacteria-Targeted Clindamycin Loaded Polymeric Nanoparticles: Effect of Surface Charge on Nanoparticle Adhesion to MRSA, Antibacterial Activity, and Wound Healing vol.11, pp.5, 2012, https://doi.org/10.3390/pharmaceutics11050236
  8. Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors vol.38, pp.2, 2012, https://doi.org/10.1080/08977194.2020.1822830