Clinical and Experimental Reproductive Medicine

  • 제39권2호
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  • Pages.41-45
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  • 2012
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Etv5, a transcription factor with versatile functions in male reproduction

  • Eo, Jinwon (Department of Biomedical Science and Technology, Konkuk University) ;
  • Song, Haengseok (Department of Biomedical Science, CHA University) ;
  • Lim, Hyunjung Jade (Department of Biomedical Science and Technology, Konkuk University)
  • 투고 : 2012.05.21
  • 심사 : 2012.06.08
  • 발행 : 2012.06.30
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초록

Transcription factors govern diverse aspects of cell growth and differentiation as major switches of gene expression. Etv5, a member of the E26 transformation-specific family of transcription factors, has many stories to share when it comes to reproduction. Etv5 deficient mice show complex infertility phenotypes both in males and females. In males, the infertility phenotype exhibited by Etv5 deficiency is sexually dimorphic, and it involves both somatic cells and germ cells. In $Etv5^{-/-}$ female mice, the problem is more complicated by hormonal involvement. This review synthesizes old and new information on this versatile transcription factor-from the inadvertent discovery of its role in the testes to its newly discovered role in maintaining spermatogonial stem cells.

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과제정보

연구 과제 주관 기관 : Konkuk University

참고문헌

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피인용 문헌

  1. Pathogenic landscape of idiopathic male infertility: new insight towards its regulatory networks vol.1, pp.None, 2016, https://doi.org/10.1038/npjgenmed.2016.23
  2. Novel Y Chromosome Retrocopies in Canids Revealed through a Genome-Wide Association Study for Sex vol.10, pp.4, 2012, https://doi.org/10.3390/genes10040320
  3. Recent Research Advances in Mitosis during Mammalian Gametogenesis vol.8, pp.6, 2019, https://doi.org/10.3390/cells8060567
  4. Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue vol.11, pp.None, 2012, https://doi.org/10.3389/fimmu.2020.632239