Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Pulmonary Cryptococcosis Mimicking Primary Lung Cancer with Multiple Lung Metastases

  • Kim, Yu Seung (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Lee, In Hee (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Hyun Seon (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Jin, Su Sin (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Lee, Jong Hwan (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Sung-Kyoung (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Song, So Hyang (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Yoo, Jinyoung (Department of Pathology, The Catholic University of Korea College of Medicine) ;
  • Kim, Chi Hong (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kwon, Soon Seog (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • Received : 2012.07.27
  • Accepted : 2012.08.30
  • Published : 2012.09.30
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Abstract

Cryptococcosis is an invasive fungal infection, which is more common in immunocompromised patients. However, pulmonary cryptococcosis can occur in immunocompetent patients and should be considered on a differential diagnosis for nodular or mass-like lesions in chest radiograph. Recently, we experienced a patient with pulmonary cryptococcosis, successfully treated with oral fluconazole therapy. A 74-year-old female patient was referred for an evaluation of abnormal images, a large consolidative mass with multiple nodular consolidations and small nodules that mimics primary lung cancer with multiple lung to lung metastases. Computed tomography-guided lung biopsy confirmed the diagnosis of pulmonary cryptococcosis. The follow-up image taken after 4 months with oral fluconazole treatment showed marked improvement.

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References

  1. Brizendine KD, Baddley JW, Pappas PG. Pulmonary cryptococcosis. Semin Respir Crit Care Med 2011;32:727-34.
  2. Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 2009;23:525-30.
  3. Hung MS, Tsai YH, Lee CH, Yang CT. Pulmonary cryptococcosis: clinical, radiographical and serological markers of dissemination. Respirology 2008;13:247-51.
  4. Nadrous HF, Antonios VS, Terrell CL, Ryu JH. Pulmonary cryptococcosis in nonimmunocompromised patients. Chest 2003;124:2143-7.
  5. Goldman JD, Vollmer ME, Luks AM. Cryptococcosis in the immunocompetent patient. Respir Care 2010;55:1499-503.
  6. Mylonakis E, Muse VV, Mino-Kenudson M. Case records of the Massachusetts General Hospital. Case 28-2011. A 74-year-old man with pemphigus vulgaris and lung nodules. N Engl J Med 2011;365:1043-50.
  7. Lindell RM, Hartman TE, Nadrous HF, Ryu JH. Pulmonary cryptococcosis: CT findings in immunocompetent patients. Radiology 2005;236:326-31.
  8. Song KD, Lee KS, Chung MP, Kwon OJ, Kim TS, Yi CA, et al. Pulmonary cryptococcosis: imaging findings in 23 non-AIDS patients. Korean J Radiol 2010;11:407-16.
  9. Choe YH, Moon H, Park SJ, Kim SR, Han HJ, Lee KS, et al. Pulmonary cryptococcosis in asymptomatic immunocompetent hosts. Scand J Infect Dis 2009;41:602-7.
  10. Chang WC, Tzao C, Hsu HH, Lee SC, Huang KL, Tung HJ, et al. Pulmonary cryptococcosis: comparison of clinical and radiographic characteristics in immunocompetent and immunocompromised patients. Chest 2006;129:333-40.
  11. Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clin Infect Dis 2010;50:291-322.
  12. Garrett L, Marr K, West S, Allada G. 74-year-old man from the pacific northwest with fever and a lung mass. Chest 2011;140:814-7.

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