Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Design, Synthesis and In Vitro Cytotoxic Activity Evaluation of New Mannich Bases

  • Bui, Trung Hieu (Department of Pharmaceutical Chemistry & Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology) ;
  • Le, Thi Thuy (Department of Pharmaceutical Chemistry & Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology) ;
  • Vu, Thu Thuy (Department of Pharmaceutical Chemistry & Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology) ;
  • Hoang, Xuan Tien (Department of Pharmaceutical Chemistry & Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology) ;
  • Luu, Van Chinh (Department of Bioactive Compounds, Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology) ;
  • Vu, Dinh Hoang (Department of Pharmaceutical Chemistry & Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology) ;
  • Tran, Khac Vu (Department of Pharmaceutical Chemistry & Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology)
  • Received : 2011.12.12
  • Accepted : 2012.02.09
  • Published : 2012.05.20
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Abstract

A series of Novel Mannich bases has been synthesized and evaluated $in$ $vitro$ cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1), and human breast cancer (MCF-7). Compound $\mathbf{9f}$ was found to be most potent against three cell lines with $IC_{50}$ values of 1.57, 1.16 and 1.21 ${\mu}g$/mL, respectively. In addition, compounds $\mathbf{9g}$, $\mathbf{10f}$ exhibited very significant activity against MCF-7 cell line with $IC_{50}$ values of 2.0 ${\mu}g$/mL.

Keywords

References

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