생명과학회지 (Journal of Life Science)

  • 제22권4호
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  • Pages.478-485
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  • 2012
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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함초분 첨가 고지방식이 흰쥐의 지방대사 연구

Glasswort Powder Diet Activates Lipid Metabolism in Rat

  • 서효빈 (경북대학교 레져스포츠학과) ;
  • 곽윤영 (경북대학교 생태환경보전학과) ;
  • 남주옥 (경북대학교 생태환경보전학과) ;
  • 송영주 (선문대학교 스포츠과학부) ;
  • 김병오 (경북대학교 생물응용학과) ;
  • 류승필 (경북대학교 레져스포츠학과)
  • Seo, Hyo-Bin (Department of Leisure Sports, College of Ecology and Environmental Science, Kyungpook National University) ;
  • Kwak, Yun-Young (Department of Ecological Environment Conservation, Kyungpook National University) ;
  • Nam, Ju-Ock (Department of Ecological Environment Conservation, Kyungpook National University) ;
  • Song, Young-Ju (Division of Sports Science, Sunmoon University) ;
  • Kim, Byung-Oh (Department of Applied Biology, Kyungpook National University) ;
  • Ryu, Sung-Pil (Department of Leisure Sports, College of Ecology and Environmental Science, Kyungpook National University)
  • 투고 : 2012.02.07
  • 심사 : 2012.04.02
  • 발행 : 2012.04.30
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초록

본 연구에서는 함초분 섭취가 지질대사에 미치는 영향을 알아보고자 하였다. 흰쥐를 일반식이 대조군(CON), 고지방식이 대조군(HFC), 고지방식이에 함초분 첨가군(HFG)로 각각 구분하여 4주간 섭취시켰다. 체중은 HFG가 HFC에 비하여 9% 정도 낮았다. 분변칼로리 분석을 한 결과, HFG의 지방량(CON에 비하여 120%, HFC에 비하여 138)과 분변 칼로리(약 110%)가 높은 것으로 나타났다. 혈중 중성지방과 LDL-C는 HFG가 HFC에 비하여 낮았으며(각각 71.8% 및 58%), HDL-C는 HFG가 HFC에 비하여 152% 높았다. 간의 FABP 발현은 HFG가 HFC보다 197% 높았으며, CPT-1 역시 동일한 경향을 보였다. 이러한 결과는 함초분 섭취가 체중의 증가를 억제하였고, 간세포 수준에서의 지방대사를 개선하였다는 점을 시사한다. 이러한 결과를 함초분이 소화관에서의 지방흡수를 억제함으로써 항비만 효과를 가지는 것으로 제안하고자 한다.

The purpose of this study was to investigate the effects of glasswort powder intake on lipid metabolism. Rats were divided into three groups: a group fed a normal diet (CON), one fed a high fat diet (HFC), and one fed a high fat diet with glasswort powder (HFG). They were fed their respective diet for four weeks. Body weight was significantly lower (9%) in the HFG group than in the HFC group at the fourth week. According to the feces analysis, the HFG group showed the highest fat level (120% vs. CON; 138% vs. HFC) and fecal calories (110%). The concentration level of TG and LDL-C was 71.8% lower in the HFG group compared to the HFC group, while the concentration level of HDL-C was 152% higher in the HFG group. Expression of FABP in the liver was 197% greater in the HFG compared to the HFC group, with the expression of CPT-1 showing a similar tendency. These results suggest that glasswort powder intake suppresses weight gain and improves fat metabolism at the level of liver cells. From these results, we suggest that glasswort powder is effective against obesity by inhibiting the absorption of fat in the digestive tract.

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