Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of acute exercise on Adiponectin and Gut hormone

일시적 운동이 혈중 Adiponectin과 Gut hormone 농도에 미치는 영향

  • Zhang, Seok-Am (Department of Exercise Prescription and Rehabilitation, Dankook University) ;
  • Lee, Jang-Kyu (Department of Exercise Prescription and Rehabilitation, Dankook University)
  • 장석암 (단국대학교 운동처방재활학과) ;
  • 이장규 (단국대학교 운동처방재활학과)
  • Received : 2012.01.10
  • Accepted : 2012.03.08
  • Published : 2012.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Adiponectin and Gut hormones(insulin, glucagon, ghrelin, PYY and GLP-1) are recently discovered peptides that are associated with lipid metabolism, insulin resistance, and control appetite. The purpose of this study was to investigate the effects of acute treadmill exercise(walking, 45min ; all-out running, 5min) on Adiponectin and gut hormones in high school ssireum player(light class, n=8; heavy class, n=8). From the experimental results, Adiponectin and ghrelin of light class were significantly higher than heavy class(p<.05), but there was no difference between pre and post exercise. Insulin level of heavy class was significantly higher than that of light class(p<.01) and no difference between pre and post exercise. Only glucagon significantly increased after exercise(p<.01), but no difference between classes. PYY and GLP-1 were no difference on classes and pre vs. post-exercise. The result of this study suggest that adiponectin, ghrelin and insulin were affected by body weight(light class vs. heavy class) and glucagon was affected by acute exercise.

최근에 발견된 Adiponectiin과 gut hormone은 지질대사와 인슐린 저항성, 그리고 식욕에 영향을 주는 것으로 보고되고 있다. 이 연구의 목적은 장기간 트레이닝을 한 고등학교 씨름선수 16명(경량급=8, 장사급=8)을 대상으로 일시적 운동을 실시하여, 운동 전 후의 혈중 Adiponectin과 Gut hormones 농도의 변화와 체중차이에 의한 농도에 차이가 있는지를 구명하고 체중의 차이가 운동의 효과에 어떠한 영향을 미치는지를 구명하고자 하였다. 실험방법으로 일시적 운동프로그램은 40분간 걷기를 한 후, 5분간 all-out 달리기를 실시하였으며 운동 전 후에 혈액을 채혈하여 분석하였다. 이 연구의 결과에서 Adiponectin과 Ghrelin의 농도는 경량급선수가 장사급선수보다 유의하게 높은 것으로 나타났으며(p<.05), 인슐린의 농도에서는 반대로 장사급선수가 경량급선수보다 유의하게 높은 것으로 나타났다(p<.01). 또한, 운동 전 후의 유의한 차이는 오직 글루카곤에서 운동 후에 유의하게 증가하였으며(p<.01), 다른 모든 변인에서 운동 전 후의 유의한 차이는 나타나지 않았다. 이 연구의 결과에서는 Adiponectin과 인슐린, Ghrelin 등의 혈중 농도에 대한 일시적인 운동 효과는 없었으며 체중 차이에 의해서 변화를 보였고, 글루카곤의 경우에만 일시적인 운동에 영향을 받아 증가되는 것으로 나타났다. 따라서 Adiponectin과 인슐린, Ghrelin 등의 농도는 지속적인 운동의 효과와 체중 차이에 영향을 받는 것으로 생각되며 글루카곤은 일시적인 운동에도 효과가 있는 것으로 사료된다.

Keywords

References

  1. Díez, J. J., and Iglesias, P, "The role of the novel adipocyte-derived hormone adiponectin in human disease", Eur J Endocrinol 148, no 3 :293-300, 2003. https://doi.org/10.1530/eje.0.1480293
  2. Weigle, D. S, "Pharmacological therapy of obesity: past, present, and future", J Clin Endocrinol Metab 88, no 6:2462-9, 2003. https://doi.org/10.1210/jc.2003-030151
  3. Medved, L. and Nieuwenhuizen, W, "Molecular mechanisms of initiation of fibrinolysis by fibrin", Thromb Haemost 89, no 3:409-19, 2003.
  4. Winzer, C., Wagner, O., Festa, A., Schneider, B., Roden, M., Bancher-Todesca, D., Pacini, G., Funahashi, T., and Kautzky-Willer, A, "Plasma adipoenctin, insulin sensitivity, and subclinical inflammation in womem with prior gestational diabetes mellitus", Diabetes Care 27, no 7:1721-7, 2004. https://doi.org/10.2337/diacare.27.7.1721
  5. Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., kita, S., Ueki, K., Eto, K., Akanuma, Y., Froguel, P., Foufelle, F., Ferre, P., Carling, D., Kimura, S., Nagai, R., kahn, B. B., & Kadowaki, T, "Adiponectin stimulstes glucose utilization and fatty-acid oxidation by activating AMPactivated protein kinase", Nature medicine, 8:1288-1295, 2002. https://doi.org/10.1038/nm788
  6. Kondo, T., Kobayashi, I., and Murakami, M, "Effect of exercise on circulating adipokine levels in obese young women", Endocrine Journal 53, no 2:189-195, 2006. https://doi.org/10.1507/endocrj.53.189
  7. Bluher, M., Bullen, J. W. Jr., Lee, J. H., Kralisch, S., Fasshauer, M., Kloting, N., Niebauer, J., Schon, M. R., Williams, C. J., and Mantzoros, C. S, "Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training", The Journal of Clinical Endocrinology and Metabolism 91, no 6:2310-6, 2006. https://doi.org/10.1210/jc.2005-2556
  8. Kriketos, A. D., Gan, S. K., Poynten, A. M., Furler, S. M., Chisholm, D. J., and Campbell, L. V, "Exercise increases adiponectin levels and insulin sensitivity in human", Diabetes Care 27, no 2:629-630, 2004. https://doi.org/10.2337/diacare.27.2.629
  9. Jurimae, J., Purge, P., and Jurimae, T, "Adiponectin and stress hormone responses to maximal sculling after volume-extended training season in elite rowers", Metabolism, 55:13-19, 2006. https://doi.org/10.1016/j.metabol.2005.06.020
  10. Jamurtas, A. Z., Theocharis, V., Koukoulis, G., Stakias, N., Fatouros, I. G., Kouretas, D., and Koutedakis, Y, "The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males", European Journal of Applied Physiology 97, no 1:122-126, 2006. https://doi.org/10.1007/s00421-006-0169-x
  11. Lee, S. H., and Kang, H. S, "The change of serum adiponectin according to acute exercise", Exercise Science 16, no. 1:47-56, 2007. https://doi.org/10.15857/ksep.2007.16.1.47
  12. Cummings, D. E, "Ghrelin and the short and long-term regulation of appetite and body weight, Physiology & Behacior, 89:71-84, 2006. https://doi.org/10.1016/j.physbeh.2006.05.022
  13. Neary, N. M., Goldstone, A. P., and Bloom, S. R. "Appetite regulation: from the gut to the hypothalamus", Clin Endocrinol 60, no 2:153-60, 2004. https://doi.org/10.1046/j.1365-2265.2003.01839.x
  14. Inui, A., Asakawa, A., Bowers, C. Y., Mantovani, G., Laviano, A., Meguid, M. M., and Fujimiya, M, "Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ, FASEB J 18, no 3:439-56, 2004. https://doi.org/10.1096/fj.03-0641rev
  15. Kim, M. S., Namkoong, C., Kim, H. S., Jang, P. G., Kim Pak, Y. M., Katakami, H., Park, J. Y, and Lee, K. U, "Chronic central administration of ghrelin reverses the sffscts of leptin", Int J Obes Relat Mwtab Disord 28, no 10:1264-1271, 2004. https://doi.org/10.1038/sj.ijo.0802647
  16. Schmidt, A., Maier, C., Schaller, G., Nowotny, P., Bayerle-Eder, M., Buranyi, B., Luger, A., and Wolzt, M, "Acute exercise has no effect on ghrelin plasma concentrations", Horm Metab Res 36, no 3:174-177, 2004. https://doi.org/10.1055/s-2004-814342
  17. Kraemer, R. R., and Castracane, V. D, "Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin", Exp Biol Med 232, no 2:184-94, 2007.
  18. Andersson, U., Treebak, J. T., Nielsen, J. N., Smith, K. L., Abbott, C. R., Small, C. J., Carling D., and Richter, E. A, "Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity", Biochem Biophys Res Commun, 329:719 -725, 2005. https://doi.org/10.1016/j.bbrc.2005.02.027
  19. Murphy, K. G., and Bloom, S. R, "Gut hormones and the regulation of energy homeostasis", Nature 14;444, no 7121:854-9, 2006. https://doi.org/10.1038/nature05484
  20. Martins, C., Morgan, L. M., Bloom, S. R., and Robertson, M. D, "Effects of exercise on gut peptides, energy intake and appetite", J Endocrinol 193, no 2:251-8, 2007. https://doi.org/10.1677/JOE-06-0030
  21. Herrmann, C., Göke, R., Richter, G., Fehmann, H. C., Arnold, R., and Göke, B, "Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients", Digestion 56, no 2:117-26, 1995. https://doi.org/10.1159/000201231
  22. O'Connor, A. M., Pola, S., Ward, B. M., Fillmore, D., Buchanan, K. D., and Kirwan, J. P, "The gastroenteroinsular response to glucose ingestion during postexercise recovery", Am J Physiol Endocrinol Metab 290, no 6:E1155-61, 2006. https://doi.org/10.1152/ajpendo.00500.2005
  23. Verdich, C., Toudro, S., Buemann, B., Lysgård, M. J., Juul, Holst. J., and Astrup, A, "The role of postprandial releases of insulin and incretin hormones in meal-induced satiety-effect of obesity and weight reduction", Int J Obes Relat Metab Disord 25, no 8:1206-14, 2001. https://doi.org/10.1038/sj.ijo.0801655
  24. Borg, G, "Perceived Exertion as an indicator of somatic stress", Scandinavian journal of Rehabilitation Medicine 2, no 2:92-98, 1970.
  25. Yalow, R. S., and Berson, S. A, "Immunoassay of endogenous plasma insulin in man", Clin Invest 39:1157-1175, 1960. https://doi.org/10.1172/JCI104130
  26. Engvall, E., and Perlmann, P, "Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G", Immunochemistry, 8:871-874, 1971. https://doi.org/10.1016/0019-2791(71)90454-X
  27. van Weemen, B. K., and Schuurs, A. H. W. M, "Immunoassay using antigen-enzyme conjugates", FEBS Letts, 15:232-236, 1971. https://doi.org/10.1016/0014-5793(71)80319-8
  28. Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., atsui, J., Takata, M., Eto, Terauchi, Y., Komeda, K., Tsunoda, M., Murakami, S., Nagai, R., and Kadowaki, T. "Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis", The journal of biological chemistry 278, no 4:2461-2468, 2003. https://doi.org/10.1074/jbc.M209033200
  29. Berg, A. H., Combs, T. P., and Scherer, P. E, "ACRP30/adiponectin: An adpokine regulating glucose and lipid metabolism", Trends in Endocrinology Metabolism 13, no 2:84-89, 2002. https://doi.org/10.1016/S1043-2760(01)00524-0
  30. Kraemer, R. R., Aboudehen, K. S., Carruth, A. K., Durand, R. T., Acevedo, E. O., Hebert, E. P., Johnson, L. G., and Castracane, V. D, "Adiponectin responses to continuous and progressively intense intermittent exercise", Med Sci Sports Exerc, 35:1320-1325, 2003. https://doi.org/10.1249/01.MSS.0000079072.23998.F3
  31. Ferguson, M. A., White, L. J., McCoy, S., Kim, H. W., Petty, T., and Wilsey, J, "Plasma adiponectin response to acute exercise in healthy subjects", European Journal of Applied physiolgy 91, no 2-3:324-329, 2004. https://doi.org/10.1007/s00421-003-0985-1
  32. Punyadeera, C., Zorenc, A. H., Koopman, R., McAinch, A. J., Smit, E., Manders, R., Keizer, H. A., Cameron-Smith, D., and van Loon, L. J, "The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle", Eur J Endocrinol, 152:427-436, 2005. https://doi.org/10.1530/eje.1.01872
  33. Jurimae, J., Purge, P., and Jurimae, T, "Adiponectin is alteres after maximal exercise in highly trained male rowers", European Journal of Applied Physiology 93, no 4:502-505, 2005. https://doi.org/10.1007/s00421-004-1238-7
  34. Hara, T., Fujiwara, H., Nakao, H., Mimura, T., Yoshikawa, T., and Fujimoto, S, "Body composition is related to increase in plasma adiponectin levels rather than training in young obese men", European Journal of applied physiology 94, no 5-6:169-172, 2005.
  35. Gavrila, A., Peng, C. K., Chan, J. L., Mietus, J. E., Goldberger, A. L., and Mantzoros, C. S, "Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns", J Clin Endocrinol Metab, 88:2838-2843, 2003. https://doi.org/10.1210/jc.2002-021721
  36. Chaudhri, O. B., Wynne, K., and Bloom S. R. "Can gut hormones control appetite and prevent obesity?", Diabetes Care 31, Suppl 2:S284-9,2008. https://doi.org/10.2337/dc08-s269
  37. Neary, N. M., Small, C. J., Druce, M. R., Park, A. J., Ellis, S. M., Semjonous, N. M., Dakin, C. L., Filipsson, K., Wang, F., Kent, A. S., Frost, G. S., Ghatei, M. A., and Bloom, S. R, "Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively", Endocrinology, 146:5120-5127, 2005. https://doi.org/10.1210/en.2005-0237
  38. Kraemer, R. R., Durand, R. J., Acevedo, E. O., Johnson, L. G., Kraemer, G. R., Hebert, E. P., and Castracane, V. D, "Rigorous running increases growth hormone and insulin-like growth factor-I without altering ghrelin", Exp Biol Med, 229:240-246, 2004a. https://doi.org/10.1177/153537020422900304
  39. Borer, K. T., Wuorinen, E., Chao C., and Burant C, "Exercise energy expenditure is not consciously detected due to oro-gastric, not metabolic, basis of hunger sensation", Appetite 45, no 2:177-81, 2005. https://doi.org/10.1016/j.appet.2005.01.012
  40. Dall, R., Kanaley, J., Hansen, T. K., Moller, N., Chridtiansen, J. S., Hosoda, H., Kangawa, K., and Jorgensen, J. O, "Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients", Eur J Endocrinol 147, no 1:65-70, 2002. https://doi.org/10.1530/eje.0.1470065
  41. Kallio, J., Pesonen U., Karvonen, M. K., Kojima, M., Hosoda, H., Kangawa, K., and Koulu, M, "Enhanced exercise-induced GH secretion in subjects with Pro7 substitution in the prepro-NPY", J Clin Endocrinol Metab, 86: 5348-5352, 2001. https://doi.org/10.1210/jc.86.11.5348
  42. Kraemer, R. R., Durand, R. J., Hollander, D. B., Tryniecki, J. L., Hebert, E. P., and Castracane, V. D, "Ghrelin and other glucoregulatory hormone responses to eccentric and concentric muscle contractions", Endocrine 24, no 1:93-8, 2004b. https://doi.org/10.1385/ENDO:24:1:093
  43. Takano, H., Morita, T., Iida, H., Asada, K., Kato, M., Uno, K., Hirose, K., Matsumoto, A., Takenaka, K., Hirata, Y., Eto, F., Nagai, R., Sato, Y., and Nakajima, T, "Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow", Eur J Appl Physiol 95, no 1:65-73, 2005. https://doi.org/10.1007/s00421-005-1389-1
  44. Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Ma, M. K., Dellinger, E. P., and Purnell, J. Q, "Plasma ghrelin levels after diet- induced weight loss or gastric bypass surgery", N Engl J Med, 346:1623-1630, 2002. https://doi.org/10.1056/NEJMoa012908
  45. Hansen, T. K., Dall, R., Hosoda, H., Kojima, M., Kangawa, K., Christiansen, J. S., and Jorgensen, J. O, "Weight loss increases circulating levels of ghrelin in human obesity", Clin Endocrinol, 56:203-206, 2002. https://doi.org/10.1046/j.0300-0664.2001.01456.x
  46. Avram, A. M., Jaffe, C. A., Symons, K. V., and Barkan A. L, "Endogenous circulating ghrelin does not mediate growth hormone rhythmicity or response to fasting", J Clin Endocrinol Metab, 90:2982-2987, 2005. https://doi.org/10.1210/jc.2004-1785
  47. Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., and Weigle, D. S, "A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans", Diabetes, 50:1714-1719, 2001. https://doi.org/10.2337/diabetes.50.8.1714
  48. Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., Cone, R. D., and Bloom, S. R, "Gut hormone PYY (3-36) physiologically inhibits food intake", Nature, 418:650-654, 2002. https://doi.org/10.1038/nature00887
  49. Degen, L., Oesch, S., Casanova, M., Graf, S., Ketterer, S., Drewe, J., and Beglinger, C, "Effect of peptide YY3-36 on food intake in humans", Gastroenterology, 129:1430-1436, 2005. https://doi.org/10.1053/j.gastro.2005.09.001
  50. Gutniak, M., Orskov, C., Holst, J. J., Ahrén, B., and Efendic, S, "Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus", N Engl J Med 326, no 20:1316-22, 1992. https://doi.org/10.1056/NEJM199205143262003
  51. Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., and Creutzfeldt, W., "Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus", J Clin Invest 91, no 1:301-7, 1993. https://doi.org/10.1172/JCI116186
  52. Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., Wilding, J. P., Smith, D. M., Ghatei, M. A., Herbert, J., and Bloom, S. R, "A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 4;379, no 6560:69-72, 1996. https://doi.org/10.1038/379069a0
  53. Kreymann, B., Williams, G., Ghatei, M. A., and Bloom, S. R, "Glucagon-like peptide-17-36: a physiologcal incretin in man", Lancet, 2:1300-1304, 1987.
  54. Hojbjerre, L., Rosenzweig, M., Dela, F., Bruun, J. M., and Stallknecht, B, "Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects", Eur J Endocrinol 157, no 5:613-23, 2007. https://doi.org/10.1530/EJE-07-0213
  55. Buchanan, K. D., O'Connor, A. M., Johnston C. F., and Boreham, C, "Regulatory peptides in the control of metabolism during starvation and exercise", Biochem Soc Trans, 24:591-593, 1996. https://doi.org/10.1042/bst0240591
  56. Larsen, P. R., Kronenberg, H. M., Shlomo, M., and Kenneth, S. P, "Williams Textbook of Endocrinology", New York: Elsevier, 2003.