한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제20권1호
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  • Pages.42-46
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  • 2012
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지
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난소 절제한 동물모델에서 콩의 섭취가 콜레스테롤과 BMD와의 상관관계에 미치는 효과

Effects of Legumes Consumption on the Association of Cholesterol and Bone Mineral Density in Ovariectomized Rats

  • 김정민 (한양대학교 식품영양학과) ;
  • 김나 (한양대학교 식품영양학과) ;
  • 박용순 (한양대학교 식품영양학과)
  • Kim, Jung-Min (Department of Food and Nutrition, Hanyang University) ;
  • Jin, Na (Department of Food and Nutrition, Hanyang University) ;
  • Park, Yong-Soon (Department of Food and Nutrition, Hanyang University)
  • 투고 : 2012.01.27
  • 심사 : 2012.02.07
  • 발행 : 2012.02.29
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초록

Soy isoflavones have been suggested to improve bone loss and lipid profile in postmenopausal women and ovariectomized rats. In present study, we investigated the hypothesis that consumption of soybean, mung bean, cowpea and azuki bean has a beneficial effect on lipid profile which associates with bone mass in ovariectomized rats. Forty two female Sprague-Dawley rats were either sham-operated (Sham) or surgically ovariectomized (OVX). Sham and OVX groups were fed a regular AIN-93M diet, but ovariectomized rats with soybean (OS), mung bean (OM), cowpea (OC) or adzuki bean (OA) were fed AIN-93M diet replacing 35% of corn starch with powdered OS, OM, OC or OA for 10 weeks. Total- and LDL-cholesterol concentrations were significantly lower in Sham and OC groups than other OVX groups. There was significant negative association between total cholesterol concentration and bone mineral density (BMD) of tibia in only OC group. In conclusion, total-cholesterol concentration was significantly and negatively correlated with BMD in rats consumed cowpea, suggesting that the reduced cholesterol concentration may have a beneficial effect on bone mass.

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참고문헌

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