Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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A Case of B Cell Lymphoma Presenting with Multiple Osteolysis in a Juvenile Golden Retriever

다발성 골 융해를 동반한 림프종 증례

  • Choi, Ji-Hye (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Jin-Soo (Haemaru Referral Animal Hospital) ;
  • Kim, Hyun-Wook (Haemaru Referral Animal Hospital) ;
  • Choi, Ul-Soo (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Chonbuk National University)
  • 최지혜 (전남대학교 수의과대학) ;
  • 이진수 (해마루 이차진료동물병원) ;
  • 김현욱 (해마루 이차진료동물병원) ;
  • 최을수 (전북대학교 수의과대학)
  • Accepted : 2011.12.13
  • Published : 2012.02.29
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Abstract

A 1.5-year-old male Golden Retriever was presented with worsening lameness of two month duration. Abnomral findings of blood works and serum chemistry included anemia, thrombocytopenia, hypercalcemia and hyperglobulinemia. Radiography revealed osteolysis of polyostotic regions including right femur and tibia, bilateral ilium, and spinous processes from the 13th thoracic vertebra to 5th lumbar vertebra. Enlarged multiple lymph nodes and mixed echo pattern of muscular region ventral to vertebra were observed with ultrasonography. Because concentrations of both parathyroid hormone and parathyroid hormone related peptide were all within reference ranges, humoral hypercalcemia by tumor was ruled out and extensive osteolysis was considered as the cause of hypercalcemia. Based on radiographic and ultrasonographic study, lymphoma, multiple myeloma and osteomyelitis were included in differential diagnosis. Fungal serologic test was negative. Monoclonal gammopathy was not found on serum protein electrophoresis. Cytological and histopathological examinations of the lytic lesions revealed neoplastic lymphoid proliferation, and B cell type clonal expansion was detected by polymerase chain reaction for the antigen receptor gene rearrangement. The case was diagnosed as B cell lymphoma involving polyostotic regions.

Keywords

References

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