Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

Evaluation of Effect of Silvernanoparticle Treated Implant on Bone Formation

은나노 처리된 임플란트의 골조직 형성에 미치는 효과 평가

  • Kim, Sin-Guen (Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine) ;
  • Yoon, Youn-Jin (Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine) ;
  • Lee, Young-Man (Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine) ;
  • Lee, Tae-Sun (Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine) ;
  • Choi, Dong-Won (Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine) ;
  • Song, Yun-Jung (Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine) ;
  • Park, Jun-Woo (Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine) ;
  • Choi, Dong-Ju (Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine)
  • 김신근 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 윤연진 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 이영만 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 이태선 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 최동원 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 송윤정 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 박준우 (한림대학교 의과대학 구강악안면외과학교실) ;
  • 최동주 (한림대학교 의과대학 구강악안면외과학교실)
  • Received : 2012.05.21
  • Accepted : 2012.07.24
  • Published : 2012.07.31
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Abstract

Purpose: To evaluate the effect of silvernanopartilce treated implants on the bone formation and osseointegration. Methods: Silvernanoparticle was produced using an anodic oxidation method. The size of silvernanoparticle ranged from 3.5 nm to 5.9 nm. To check the effect of the capability of osseointegration of silvernanoparticle coated Implant, 32 implants (16 piece of Implant treated with nanoparticle, and 16 piece of Implant was not treated for control) were placed at both the tibia of 8 New Zealand white rabbits. After 4 weeks, 4 rabbits were sacrificed and the removal torque was measured for comparison of the osseointagration ability. Further, 4 rabbits were sacrificed and sliced samples were made. H&E stain was done for microscopic finding. Results: The removal torque of the experimental group was $102.37{\pm}30.54$ N/cm, and the control group was $73.30{\pm}19.97$ N/cm. It was statistically significant (P<0.001). Microscopic finding also shows extinguish results in silvernanoparticle treated implants. Bone formation rate of the experimental group was 43.94% and the control group was 7.58%. It was observed to be statistically significant (P=0.017). Bone to implant contact rate of the experimental group was 58.09%, and the control group was 19.43%. It was found with statistical significance (P<0.001). Conclusion: The silvernanopartilce treated implant shows a better capability of bone regeneration and osseointegration than the non-treated one. Technology to produce smaller particles would make silver more useful and safer.

Keywords

References

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