Asian Pacific Journal of Cancer Prevention

  • 제13권12호
  • /
  • Pages.6527-6531
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Complement Receptor 1 Expression in Peripheral Blood Mononuclear Cells and the Association with Clinicopathological Features And Prognosis of Nasopharyngeal Carcinoma

  • He, Jian-Rong (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center) ;
  • Xi, Jing (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center) ;
  • Ren, Ze-Fang (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center) ;
  • Qin, Han (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center) ;
  • Zhang, Ying (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center) ;
  • Zeng, Yi-Xin (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center) ;
  • Mo, Hao-Yuan (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center) ;
  • Jia, Wei-Hua (State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center)
  • 발행 : 2012.12.31
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초록

Purpose: Complement receptor 1 (CR1) is induced by Epstein-Barr virus (EBV) and may be a potential biomarker of nasopharyngeal carcinoma (NPC). We conducted the present study to evaluate the association of CR1 expression with clinicopathological features and prognosis of NPC. Methods: We enrolled 145 NPC patients and 110 controls. Expression levels of CR1 in peripheral blood mononuclear cells (PBMCs) were detected using quantitative real-time PCR and associations with clinicopathological features and prognosis were examined. Results: CR1 levels in the NPC group [3.54 (3.34, 3.79)] were slightly higher than those in the controls [3.33 (3.20, 3.47)] (P<0.001). Increased CR1 expression was associated with histology classification (type III vs. type II, P=0.002), advanced clinical stage (P=0.003), high T stage (P=0.017), and poor overall survival (HR, 4.89; 95% CI, 1.23-19.42; P=0.024). However, there were no statistically significant differences in CR1 expression among N or M stages. Conclusion: These findings indicate that CR1 expression in PBMCs may be a new biomarker for prognosis of NPC and a potential therapeutic target.

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피인용 문헌

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