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A 10-year Study of Esophageal Cancer in Guilan Province, Iran: The Guilan Cancer Registry Study (GCRS)

  • Mansour-Ghanaei, Fariborz (Medicine Department, Guilan University of Medical Sciences) ;
  • Heidarzadeh, Abtin (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Naghipour, Mohammad Reza (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Joukar, Farahnaz (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Valeshabad, Ali Kord (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Fallah, Mohammad-Sadegh (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Rezvani, Seyed Mahmoud (Health Department, Guilan University of Medical Sciences) ;
  • Sedigh-Rahimabadi, Massih (Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences) ;
  • Rokhshad, Hasan (Health Department, Guilan University of Medical Sciences) ;
  • Dadashi, Arsalan (Health Department, Guilan University of Medical Sciences)
  • Published : 2012.12.31

Abstract

Background: Northern Iran counts as one of the highest prevalence regions for esophageal cancer (EC) worldwide. This study was designed to assess the epidemiologic aspects of EC in north central and northwest Iran over a 10 year period. Materials and Methods: The Guilan cancer registry study (GCRS) is a population-based cancer registry study featuring retrospective (1996-2003) and prospective (2004-2005) phases. A detailed questionnaire based on WHO standards for cancer registratration was applied to gather the required information. Two trained physicians coded information using ICD-O-3 in close coordination with an expert pathologist. Results: A total of 19,936 cases of malignancy (mean age $55.4{\pm}18.0$ years, range: 1-98 years) were registered, including 1,147 cases (670 males, 447 female; mean age: $64.0{\pm}11.5$ years) of EC. In 1996 the male/female ratio among patients with EC was 1.25 which increased to 1.53 in 2005. The lower third of the esophagus still remained the most common site of tumors. The average age-standardized rate (ASR) was 6.9 and 4.1 per $10^5$ men and women, respectively. In 1996, the ASRs were 7.2 and 5.2 per $10^5$ men and women which decreased to 6.9 and 4.1 per $10^5$ in 2004-2005. Squamous cell carcinoma (SCC) was the most prevalent histological subtype of EC accounting over 80% of cases. Conclusions: However the prevalence of adenocarcinoma (ADC) showed an increase to 18.4%. Guilan province may be considered a relatively low incidence region for EC.

Keywords

References

  1. Babaei M, Mousavi S, Malek M, et al (2005). Cancer occurrence in Semnan Province, Iran: results of a population-based cancer registry. Asian Pac J Cancer Prev, 6, 159-64.
  2. Baquet CR, Commiskey P, Mack K, et al (2005). Esophageal cancer epidemiology in blacks and whites: racial and gender disparities in incidence, mortality, survival rates and histology. J Natl Med Assoc, 97, 1471-8.
  3. Brown LM, Devesa SS (2002). Epidemiologic trends in esophageal and gastric cancer in the United States. Surg Oncol Clin N Am, 11, 235-56.
  4. Brown LM, Hoover R, Silverman D, et al (2001). Excess incidence of squamous cell esophageal cancer among U.S. Black men: role of social class and other risk factors. Am J Epidemiol, 153, 114-22. https://doi.org/10.1093/aje/153.2.114
  5. Castellsague X, Munoz N, De Stefani E, et al (2000). Influence of mate drinking, hot beverages, and diet on esophageal cancer risk in South America. Int J Cancer, 88, 658-64. https://doi.org/10.1002/1097-0215(20001115)88:4<658::AID-IJC22>3.0.CO;2-T
  6. Derakhshan MH, Malekzadeh R, Watabe H, et al (2008). Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. Gut, 57, 298-305. https://doi.org/10.1136/gut.2007.137364
  7. Eser S, Yakut C, Özdemir R, et al (2010). Cancer incidence rates in Turkey in 2006: a detailed registry based estimation. Asian Pac J Cancer Prev, 11, 1731-9.
  8. Ghadirian P (1987). Thermal irritation and esophageal cancer in northern Iran. Cancer, 60, 1909-14. https://doi.org/10.1002/1097-0142(19871015)60:8<1909::AID-CNCR2820600840>3.0.CO;2-Y
  9. Ghadirian P, Stein GF, Gorodetzky C, et al (1985). Oesophageal cancer studies in the Caspian littoral of Iran: some residual results, including opium use as a risk factor. Int J Cancer, 35, 593-7. https://doi.org/10.1002/ijc.2910350505
  10. Gonzalez CA, Pera G, Agudo A, et al (2006). Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Int J Cancer, 118, 2559-66. https://doi.org/10.1002/ijc.21678
  11. Haghdoost AA, Hosseini H, Chamani G, et al (2008). Rising incidence of adenocarcinoma of the esophagus, in Kerman. Arch Iran Med, 11, 364-70.
  12. Hewer T, Rose E, Ghadirian P, et al (1978). Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus. Lancet, 2, 494-6.
  13. Hossein SM, Mirinezhad K, Farhang S, et al (2006). Gastrointestinal cancer occurrence in East Azarbaijan: a five year study from North Western Iran. Asian Pac J Cancer Prev, 7, 309-12.
  14. Islami F, Pourshams A, Nasrollahzadeh D, et al (2009). Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: population based case-control study. BMJ, 338, 929. https://doi.org/10.1136/bmj.b929
  15. Jakszyn P, Gonzalez CA (2006). Nitrosamine and related food intake and gastric and oesophageal cancer risk: a systematic review of the epidemiological evidence. World J Gastroenterol, 12, 4296-303.
  16. Jansson C, Johansson AL, Nyren O, et al (2005). Socioeconomic factors and risk of esophageal adenocarcinoma: a nationwide Swedish case-control study. Cancer Epidemiol Biomarkers Prev, 14, 1754-61. https://doi.org/10.1158/1055-9965.EPI-05-0140
  17. Kairakbaev MK (1978). Malignant neoplasms among ethnic groups in the Kazakh SSR. Vopr Onkol, 24, 100-4.
  18. Kamangar F, Malekzadeh R, Dawsey SM, et al (2007). Esophageal cancer in northeastern Iran: A review. Arch Iran Med, 10, 70-82.
  19. Kamangar F, Dores GM, Anderson WF (2006). Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 24, 2137-50. https://doi.org/10.1200/JCO.2005.05.2308
  20. Ke L (2002). Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-90. Int J Cancer, 102, 271-4. https://doi.org/10.1002/ijc.10706
  21. Kmet J, Mahboubi E (1972). Esophageal cancer in the Caspian littoral of Iran: initial studies. Science, 175, 846-53. https://doi.org/10.1126/science.175.4024.846
  22. Kollarova H, Machova L, Horakova D, et al (2007). Epidemiology of esophageal cancer--an overview article. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 151, 17-20. https://doi.org/10.5507/bp.2007.003
  23. Mahboubi E (1971). Epidemiologic study of esophageal carcinoma in Iran. Int Surg, 56, 68-71.
  24. Mahboubi E, Kmet J, Cook PJ, et al (1973).Oesophageal cancer studies in the Caspian littoral of Iran: the Caspian cancer registry. Br J Cancer, 28, 197-214. https://doi.org/10.1038/bjc.1973.138
  25. Malaveille C, Friesen M, Camus AM, et al (1982). Mutagens produced by the pyrolysis of opium and its alkaloids as possible risk factors in cancer of the bladder and oesophagus. Carcinogenesis, 3, 577-85. https://doi.org/10.1093/carcin/3.5.577
  26. Malekzadeh R, Mohamadnejad M, Merat S, et al (2005). Obesity pandemic: an Iranian perspective. Arch Iran Med, 8, 1-7.
  27. Malekzadeh R, Nasseri-Moghaddam S, Sotoudeh M (2003). Gastroesophageal reflux disease: the new epidemic. Arch Iran Med, 6, 127-40.
  28. Mohebbi M, Mahmoodi M, Wolfe R, et al (2008). Geographical spread of gastrointestinal tract cancer incidence in the Caspian Sea region of Iran: spatial analysis of cancer registry data. BMC Cancer, 8, 137. https://doi.org/10.1186/1471-2407-8-137
  29. Moradi A, Kalavi K, Qujeq D, et al (2007). Risk factors of esophageal cancer in Turkmen Sahra of Iran. TJC, 37, 16-21.
  30. Naghavi M (2000). Death report from 10 provinces in Iran. Tehran, Ministry of Health.
  31. Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  32. Perry PE, Thomson EJ, Vijayalaxm I, et al (1983). Induction of SCE by opium pyrolysates in CHO cells and human peripheral blood lymphocytes. Carcinogenesis, 4, 227-30. https://doi.org/10.1093/carcin/4.2.227
  33. Pourshams A, Khademi H, Malekshah AF, et al (2010). Cohort profile: the golestan cohort study--a prospective study of oesophageal cancer in northern Iran. Int J Epidemiol, 39, 52-9. https://doi.org/10.1093/ije/dyp161
  34. Roth M, Qiao Y, Rothman N, et al (2001). High urine 1-hydroxypyrene glucoronide concentration in Linxian, China, an area of high risk for squamous oesophageal cancer. Biomarkers, 6, 381-6. https://doi.org/10.1080/13547500110044780
  35. Sadjadi A, Marjani H, Semnani S, et al (2010). Esophageal Cancer in Iran: A Review. Middle East J Cancer, 1, 5-14.
  36. Sadjadi A, Zahedi M, Moghadam S, et al (2007). The first population based cancer survey in Kerman Province of Iran. Iran J Public Hlth, 36, 26-34.
  37. Sadjadi A, Nouraie M, Mohagheghi MA, et al (2005). Cancer occurrence in Iran in 2002, an international perspective. Asian Pac J Cancer Prev, 6, 359-63.
  38. Sadjadi A, Malekzadeh R, Derakhshan MH, et al (2003). Cancer occurrence in Ardabil: results of a population-based cancer registry from Iran. Int J Cancer, 107, 113-8. https://doi.org/10.1002/ijc.11359
  39. Saenko AI (1975). The epidemiology of cancer in Central Asia. Vopr Onkol, 21, 40-4.
  40. Saidi F, Sepehr A, Fahimi S, et al (2000). Oesophageal cancer among the Turkomens of North-East Iran. Br J Cancer, 83, 1249-54. https://doi.org/10.1054/bjoc.2000.1414
  41. Samadi F, Babaei M, Yazdanbod A, et al (2007). Survival rate of gastric and esophageal cancers in Ardabil province, North- West of Iran. Arch Iran Med, 10, 32-7.
  42. Semnani S, Sadjadi A, Fahimi S, et al (2006). Declining incidence of esophageal cancer in the Turkmen Plain, eastern part of the Caspian Littoral of Iran: a retrospective cancer surveillance. Cancer Detect Prev, 30, 14-29. https://doi.org/10.1016/j.cdp.2005.11.002
  43. Sepehr A, Kamangar F, Fahimi S, et al (2005). Poor oral health as a risk factor for esophageal squamous dysplasia in northeastern Iran. Anticancer Res, 25, 543-6.
  44. Sepehr A, Razavi P, Saidi F, et al (2000). Esophageal exfoliative cytology samplers. A comparison of three types. Acta Cytol, 44, 797-804. https://doi.org/10.1159/000328564
  45. Yang CX, Wang HY, Wang ZM, et al (2005). Risk factors for esophageal cancer: a case control study in southwestern China. Asian Pac J Cancer Prev, 6, 48-53.
  46. Zaridze DG, Basieva T, Kabulov M, et al (1992). Oesophageal cancer in the Republic of Karakal pakstan. Int J Epidemiol, 21, 643-8. https://doi.org/10.1093/ije/21.4.643

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