DOI QR코드

DOI QR Code

Antifungal Activities of Essential Oils from Six Conifers against Aspergillus fumigatus

  • Jang, Soo-Kyeong (Department of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University) ;
  • Lee, Su-Yeon (Department of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University) ;
  • Kim, Seon-Hong (Department of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University) ;
  • Hong, Chang-Young (Department of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University) ;
  • Park, Mi-Jin (Division of Wood Chemistry & Microbiology, Department of Forest Resources Utilization, Korea Forest Research Institute) ;
  • Choi, In-Gyu (Department of Forest Sciences, College of Agriculture & Life Sciences, Seoul National University)
  • 투고 : 2012.03.09
  • 심사 : 2012.03.23
  • 발행 : 2012.03.25

초록

The antifungal activities of the essential oils from Pinus densiflora, Pinus koraiensis, Abies holophylla, Larix kaempferi, Cryptomeria japonica and Chamaecyparis obtusa against Aspergillus fumigatus were evaluated. Essential oils were extracted from each conifer leaves for 8 h using water distillation method. The essential oil from A. holophylla appeared the strongest antifungal activity among the six oils with MIC value 0.125 mg/$m{\ell}$. The composition of the A. holophylla oil was analysed by GC/MS and then MIC was determined for main constituents of the oil. As the results, borneol and ${\alpha}$-bisabolol, which have a hydroxyl group, showed effective antifungal activities against A. fumigatus (0.25 mg/$m{\ell}$). In addition, the synergistic antifungal effects were observed in the combination of borneol and ${\alpha}$-bisabolol.

키워드

참고문헌

  1. Bakkali, F., S. Averbeck, D. Averbeck, and M.Idaomar. 2008. Biological effects of essential oils - A review. Food and Chemical Toxicology 46 (2): 446-475. https://doi.org/10.1016/j.fct.2007.09.106
  2. Burt, S. 2003. Essential oils: their antibac- terial properties and potential applications in foods-a review. International Journal of Food Microbiology 94(1): 223-253 https://doi.org/10.1016/j.ijfoodmicro.2004.03.022
  3. Han, K. H. 2007. Antifungal Activity of Essential Oil from Asarum sieboldii against Epidermal and Opportunistic Pathogenic Fungi. The Korean Journal of Mycology 35(1): 58-60. https://doi.org/10.4489/KJM.2007.35.1.058
  4. Farag, R. S., Z. Y. Daw, F. M. Hewedi, and G. S. A. El-Baroty. 1989. Antimicrobial activity of some Egyptian spice essential oils. Journal of Food Protection 52(9): 665-667. https://doi.org/10.4315/0362-028X-52.9.665
  5. Hammer, K. A., C. F. Carson, and T. V. Riley. 1999. Antimicrobial activity of essential oils and other plant extracts. Journal of Applied Microbiology 86(6): 985-990. https://doi.org/10.1046/j.1365-2672.1999.00780.x
  6. Muller-Riebau, F., B. Berger, and O. Yegen, 1995. Chemical composition and fungitoxic properties to phytopathogenic fungi of essential oils of selected aromatic plants growing wild in Turkey. J. Agric. Food Chem. 43(8): 2262-2266. https://doi.org/10.1021/jf00056a055
  7. Pintore, G., M. Usai, P. Bradesi, C. Juliano, G. Boatto, F. Tomi, M. Chessa, R. Cerri, and J. Casanova. 2002. Chemical composition and antimicrobial activity of Rosmarinus officinalis L. oils from Sardinia and Corsica. Flavour and Fragrance Journal 17(1): 15-19. https://doi.org/10.1002/ffj.1022
  8. Smith-Palmer, A., J. Stewart, and L. Fyfe. 1998. Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens. Letters in Food Microbiology 26(2): 118-122. https://doi.org/10.1046/j.1472-765X.1998.00303.x
  9. Wilson, C. L., J. M. Solar, A. El Ghaouth, and M. E. Wisniewski, 1997. Rapid evaluation of plant extracts and essential oils for antifungal activity against Botrytis cinerea. Plant Dis. 81(2): 204-210. https://doi.org/10.1094/PDIS.1997.81.2.204
  10. Cheng, S. S., H. Y. Lin, and S. T. Chang. 2005. Chemical Composition and Antifungal Activity of Essential Oils from Different Tissues of Japanese Cedar (Cryptomeria japonica). J. Agric. Food Chem. 53(3): 614-619. https://doi.org/10.1021/jf0484529
  11. Latge, J. P. 1999. Aspergillus fumigatus and aspergillosis. Clin. Microbiol. Rev. 12(2): 310-350.
  12. Mullins, J., R. Harvey, and A. Seaton. 1976. Sources and incidence of airborne Aspergillus fumigatus (Fres). Clin. Allergy 6(3): 209-217. https://doi.org/10.1111/j.1365-2222.1976.tb01899.x
  13. Hope, W. W., M. J. Kruhlak, C. A. Lyman, R. Petraitiene, V. Petraitis, A. Francesconi, M. Kasai, D. Mickiene, T. Sein, and J. Peter. 2007. Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy. Journal of Infectious Diseases 195(3): 455. https://doi.org/10.1086/510535
  14. Ben-Ami, R., R. E. Lewis, and D. P. Kontoyiannis. 2010. Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection. Br. J. Haematol 150 (4): 406-417.
  15. Bodey, G., B. Bueltmann, W. Duguid, D. Gibbs, H. Hanak, M. Hotchi, G. Mall, P. Martino, F. Meunier, S. Milliken, S. Naoe, M. Okudaira, D. Scevola, and J. van't Wout. 1992. Fungal infections in cancer patients: an international autopsy survey. Eur. J. Clin. Microbiol. Infect. Dis. 11 (2): 99-109. https://doi.org/10.1007/BF01967060
  16. Skandamis, P. N. and G. J. E. Nychas. 2001. Effect of oregano essential oil on microbiological and physico-chemical attributes of minced meat stored in air and modified atmospheres. Journal of Applied Microbiology 91(6): 1011-1022. https://doi.org/10.1046/j.1365-2672.2001.01467.x
  17. Carson, C. F., B. J. Mee, and T. V. Riley. 2002. Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage and salt tolerance assays and electron microscopy. Antimicrobial Agents and Chemotherapy 46(6): 1914-1920. https://doi.org/10.1128/AAC.46.6.1914-1920.2002
  18. Knobloch, K., A. Pauli, B. Iberl, H. Weigand, and N. Weis. 1989. Antibacterial and antifungal properties of essential oil components. Journal of Essential Oil Research 1: 119-128. https://doi.org/10.1080/10412905.1989.9697767
  19. Sikkema, J., J. A. M. De Bont, and B. Poolman. 1994. Interactions of cyclic hydrocarbons with biological membranes. Journal of Biological Chemistry 269(11): 8022-8028.
  20. Oosterhaven, K., B. Poolman, and E. J. Smid. 1995. S-carvone as a natural potato sprout inhibiting, fungistatic and bacteristatic compound. Industrial Crops and Products 4(1): 23-31. https://doi.org/10.1016/0926-6690(95)00007-Y
  21. Ultee, A., E. P. W. Kets, M. Alberda, F. A. Hoekstra, and E. J. Smid. 2000. Adaptation of the food-borne pathogen Bacillus cereus to carvacrol. Archives of Microbiology 174(4): 233-238. https://doi.org/10.1007/s002030000199
  22. Ultee, A., M .H. J. Bennink, and R. Moezelaar. 2002. The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus. Applied and Environmental Microbiology 68(4): 1561-1568. https://doi.org/10.1128/AEM.68.4.1561-1568.2002
  23. Juven, B. J., J. Kanner, F. Schved, and H. Weisslowicz. 1994. Factors that interact with the antibacterial action of thyme essential oil and its active constituents. Journal of Applied Bacteriology 76(6): 626-631. https://doi.org/10.1111/j.1365-2672.1994.tb01661.x
  24. Delaquis, P. J., K. Stanich, B. Girard, and G. Mazza. 2002. Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils. International Journal of Food Microbiology 74(1-2): 101-109. https://doi.org/10.1016/S0168-1605(01)00734-6
  25. Dorman, H. J. D. and S. G. Deans. 2000. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. Journal of Applied Microbiology 88(2): 308-316. https://doi.org/10.1046/j.1365-2672.2000.00969.x
  26. Lambert, R. J. W., P. N. Skandamis, P. Coote, and G. J. E. Nychas. 2001. A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. Journal of Applied Microbiology 91 (3): 453-462. https://doi.org/10.1046/j.1365-2672.2001.01428.x
  27. Alviano, W. S., R. R. Mendonça-Filho, D. S. Alviano, H. R. Bizzo, T. Souto-Padrón, M. L. Rodrigues, A. M. Bolognese, C. S. Alviano, and M. M. G. Souza. 2005. Antimicrobial activity of Croton cajucara Benth linalool-rich essential oil on artificial biofilms and planktonic microorganisms. Oral Microbiol Immunol. 20(2): 101-105. https://doi.org/10.1111/j.1399-302X.2004.00201.x