Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effects of Docosahexaenoic Acid on Neurotransmission

  • Tanaka, Kazuhiro (Department of Pharmacology, National University of Singapore) ;
  • Farooqui, Akhlaq A. (Department of Molecular and Cellular Biochemistry, The Ohio State University) ;
  • Siddiqi, Nikhat J. (Department of Biochemistry, College of Science, King Saud University) ;
  • Alhomida, Abdullah S. (Department of Biochemistry, College of Science, King Saud University) ;
  • Ong, Wei-Yi (Department of Anatomy, National University of Singapore)
  • Received : 2011.09.27
  • Accepted : 2011.12.05
  • Published : 2012.03.31
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Abstract

Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid (PUFA) in the brain and a structural component of neuronal membranes. Changes in DHA content of neuronal membranes lead to functional changes in the activity of receptors and other proteins which might be associated with synaptic function. Accumulating evidence suggests the beneficial effects of dietary DHA supplementation on neurotransmission. This article reviews the beneficial effects of DHA on the brain; uptake, incorporation and release of DHA at synapses, effects of DHA on synapses, effects of DHA on neurotransmitters, DHA metabolites, and changes in DHA with age. Further studies to better understand the metabolome of DHA could result in more effective use of this molecule for treatment of neurodegenerative or neuropsychiatric diseases.

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