Journal of agricultural medicine and community health (농촌의학ㆍ지역보건)

Korean Society for Rural Medicine and Community Health (한국농촌의학지역보건학회)
권호 표지
DOI QR코드

DOI QR Code

Relationship of Average Volume of Alcohol Consumption and Binge Drinking to Arterial Stiffness in Community-Dwelling Healthy Adults

지역사회 건강한 성인에서 알코올 섭취량 및 폭음과 동맥경직도의 관련성

  • Kweon, Sun-Seog (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Lee, Young-Hoon (Department of Preventive Medicine, Wonkwang University College of Medicine)
  • 권순석 (전남대학교 의과대학 예방의학교실) ;
  • 이영훈 (원광대학교 의과대학 예방의학교실)
  • Received : 2011.12.09
  • Accepted : 2012.03.16
  • Published : 2012.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The purpose of this study was to investigate the association of the average volume of alcohol consumption and binge drinking with arterial stiffness. Methods: The study population consisted of 5944 community-dwelling healthy adults aged 50 years and older. Average volume of alcohol consumption was calculated and frequency of binge drinking defined as the consumption of 7 or more drinks for men and 5 or more for women on a single occasion, was assessed using a structured interview. High brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, was defined as the highest gender-specific quartile of maximal baPWV distribution in the study population. Results: Compared to never drinkers, the multivariate-adjusted odds ratio (OR) of men who consumed 0.1-10.0, 10.1-20.0, 20.1-40.0, and >40.0 g/day was 0.93, 1.18, 1.38, and 2.36, respectively. The OR was 0.90, 0.97, 1.45, and 1.82 in women consuming 0.1-5.0, 5.1-10.0, 10.1-20.0, and >20.0 g/day, respectively. Binge drinking of <1 day/week (OR=1.66, 95% confidence interval [CI]=1.13-2.42) and ${\geq}1$ day/week (OR=1.61, 95% CI=1.04-2.50) were associated with increased risk for high baPWV in men, and binge drinking of ${\geq}1$ day/week (OR=3.12, 95% CI=1.16-8.34) was associated with increased risk for high baPWV in women. Conclusions: A J-shaped relationship between the average volume of alcohol consumption and high baPWV was observed, suggesting the detrimental effects of heavy alcohol drinking on arterial stiffness. Binge drinking was also significant risk factors for increased arterial stiffness, independently of the average volume of alcohol consumption.

지역사회 성인을 대상으로 알코올 섭취량과 동맥경직도의 관련성을 파악하였으며, 아울러 폭음과 동맥경직도의 관련성을 살펴보았다. 지역사회기반 코호트 연구에 참여한 50세 이상 성인 5944명을 대상으로 하루 평균 알코올 소비량(g/day)과 월 폭음 빈도를 조사하였다. 상완-발목동맥 맥파전도속도(baPWV)를 측정한 후 남녀 각각에서 baPWV 4사분위에 해당하는 집단을 'high baPWV'로 정의하였다. 남성 알코올 섭취군의 교차비는 비음주군과 비교해서 유의한 차이가 없었지만, >40.0 g/d 알코올 섭취군의 교차비는 유의하게 증가하였다. 모든 여성 알코올 섭취군의 교차비는 비음주군에 비해서 유의한 차이가 없었다. 남성에서는 비폭음군에 비해 주 1회 미만 폭음군 및 주 1회 이상 폭음군의 high baPWV에 대한 교차비가 유의하게 증가하였다. 여성에서는 비폭음군에 비해 주 1회 이상 폭음군의 교차비가 유의하게 증가하였다. 남녀 모두에서 적당한 음주는 동맥경직도의 위험성이 낮은 반면, 과도한 음주는 동맥경직도의 위험성이 증가하였으며, 전반적으로 알코올 섭취량과 baPWV로 측정한 동맥경직도 사이에는 J자 형태의 관련성이 있었다. 또한 알코올 섭취량을 포함한 기존의 심혈관 위험요인과는 독립적으로 남녀 모두에서 폭음이 동맥경직도와 유의한 관련성이 있었다.

Keywords

References

  1. O'Keefe JH, Bybee KA, Lavie CJ. Alcohol and cardiovascular health: the razor-sharp double-edged sword. J Am Coll Cardiol 2007;50(11):1009-1014 https://doi.org/10.1016/j.jacc.2007.04.089
  2. Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G. Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med 2006;166(22):2437-2445 https://doi.org/10.1001/archinte.166.22.2437
  3. Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolainen K. Alcohol and coronary heart disease: a meta-analysis. Addiction 2000;95(10):1505-1523 https://doi.org/10.1046/j.1360-0443.2000.951015056.x
  4. Hirata K, Kawakami M, O'Rourke MF. Pulse wave analysis and pulse wave velocity: a review of blood pressure interpretation 100 years after Korotkov. Circ J 2006;70(10): 1231-1239 https://doi.org/10.1253/circj.70.1231
  5. van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, et al. Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 2001;32(2):454-460 https://doi.org/10.1161/01.STR.32.2.454
  6. Lehmann ED. Clinical value of aortic pulse-wave velocity measurement. Lancet 1999;354(9178):528-529 https://doi.org/10.1016/S0140-6736(99)00179-8
  7. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001;37(5):1236-1241 https://doi.org/10.1161/01.HYP.37.5.1236
  8. Amar J, Ruidavets JB, Chamontin B, Drouet L, Ferrieres J. Arterial stiffness and cardiovascular risk factors in a population-based study. J Hypertens 2001;19(3):381-387 https://doi.org/10.1097/00004872-200103000-00005
  9. Aso K, Miyata M, Kubo T, Hashiguchi H, Fukudome M, Fukushige E, et al. Brachial-ankle pulse wave velocity is useful for evaluation of complications in type 2 diabetic patients. Hypertens Res 2003;26(10): 807-813 https://doi.org/10.1291/hypres.26.807
  10. Kubo T, Miyata M, Minagoe S, Setoyama S, Maruyama I, Tei C. A simple oscillometric technique for determining new indices of arterial distensibility. Hypertens Res 2002;25(3):351-358 https://doi.org/10.1291/hypres.25.351
  11. Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002;25(3):359-364 https://doi.org/10.1291/hypres.25.359
  12. Sierksma A, Muller M, van der Schouw YT, Grobbee DE, Hendriks HF, Bots ML. Alcohol consumption and arterial stiffness in men. J Hypertens 2004;22(2):357-362 https://doi.org/10.1097/00004872-200402000-00020
  13. Sierksma A, Lebrun CE, van der Schouw YT, Grobbee DE, Lamberts SW, Hendriks HF, et al. Alcohol consumption in relation to aortic stiffness and aortic wave reflections: a cross-sectional study in healthy postmenopausal women. Arterioscler Thromb Vasc Biol 2004;24(2):342-348 https://doi.org/10.1161/01.ATV.0000110784.52412.8f
  14. Kurihara T, Tomiyama H, Hashimoto H, Yamamoto Y, Yano E, Yamashina A. Excessive alcohol intake increases the risk of arterial stiffening in men with normal blood pressure. Hypertens Res 2004;27(9): 669-673 https://doi.org/10.1291/hypres.27.669
  15. Mattace-Raso FU, van der Cammen TJ, van den Elzen AP, Schalekamp MA, Asmar R, Reneman RS, et al. Moderate alcohol consumption is associated with reduced arterial stiffness in older adults: the Rotterdam study. J Gerontol A Biol Sci Med Sci 2005;60(11):1479-1483 https://doi.org/10.1093/gerona/60.11.1479
  16. Ko KD, Lee KY, Cho B, Park MS, Son KY, Ha JH, et al. Disparities in health-risk behaviors, preventive health care utilizations, and chronic health conditions for people with disabilities: the Korean National Health and Nutrition Examination Survey. Arch Phys Med Rehabil 2011;92(8):1230-1237 https://doi.org/10.1016/j.apmr.2011.03.004
  17. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502
  18. Corrao G, Bagnardi V, Zambon A, La Vecchia C. A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med 2004;38(5):613-619 https://doi.org/10.1016/j.ypmed.2003.11.027
  19. Mukamal KJ, Chiuve SE, Rimm EB. Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles. Arch Intern Med 2006;166(19):2145-2150 https://doi.org/10.1001/archinte.166.19.2145
  20. Suh I, Shaten BJ, Cutler JA, Kuller LH. Alcohol use and mortality from coronary heart disease: the role of high-density lipoprotein cholesterol. The Multiple Risk Factor Intervention Trial Research Group. Ann Intern Med 1992;116(11):881-887 https://doi.org/10.7326/0003-4819-116-11-881
  21. Mukamal KJ, Mackey RH, Kuller LH, Tracy RP, Kronmal RA, Mittleman MA, et al. Alcohol consumption and lipoprotein subclasses in older adults. J Clin Endocrinol Metab 2007;92(7):2559-2566 https://doi.org/10.1210/jc.2006-2422
  22. Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 1999;319(7224): 1523-1528 https://doi.org/10.1136/bmj.319.7224.1523
  23. Mukamal KJ, Jadhav PP, D'Agostino RB, Massaro JM, Mittleman MA, Lipinska I, et al. Alcohol consumption and hemostatic factors: analysis of the Framingham Offspring cohort. Circulation 2001;104(12):1367-1373 https://doi.org/10.1161/hc3701.096067
  24. Ruf JC. Alcohol, wine and platelet function. Biol Res 2004;37(2):209-215
  25. Agarwal DP. Cardioprotective effects of light-moderate consumption of alcohol: a review of putative mechanisms. Alcohol 2002;37(5):409-415
  26. Marmot MG, Elliott P, Shipley MJ, Dyer AR, Ueshima H, Beevers DG, et al. Alcohol and blood pressure: the INTERSALT study. BMJ 1994;308(6939):1263-1267 https://doi.org/10.1136/bmj.308.6939.1263
  27. Saremi A, Hanson RL, Tulloch-Reid M, Williams DE, Knowler WC. Alcohol consumption predicts hypertension but not diabetes. J Stud Alcohol 2004;65(2):184-190 https://doi.org/10.15288/jsa.2004.65.184
  28. Renaud SC, Ruf JC. Effects of alcohol on platelet functions. Clin Chim Acta 1996;246(1-2):77-89 https://doi.org/10.1016/0009-8981(96)06228-6
  29. Nakanishi N, Kawashimo H, Nakamura K, Suzuki K, Yoshida H, Uzura S, et al. Association of alcohol consumption with increase in aortic stiffness: a 9-year longitudinal study in middle-aged Japanese men. Ind Health 2001;39(1):24-28 https://doi.org/10.2486/indhealth.39.24
  30. Nakanishi N, Yoshida H, Kawashimo H, Suzuki K, Nakamura K, Tatara K. Alcohol consumption and risk for increased aortic pulse wave velocity in middle-aged Japanese men. Angiology 2001;52(8):533-542 https://doi.org/10.1177/000331970105200805
  31. Namekata T, Moore D, Suzuki K, Mori M, Hatano S, Hayashi C, et al. A study of the association between the aortic pulse wave velocity and atherosclerotic risk factors among Japanese Americans in Seattle, U.S.A. Nippon Koshu Eisei Zasshi 1997;44(12):942-951
  32. Fan AZ, Russell M, Naimi T, Li Y, Liao Y, Jiles R, et al. Patterns of alcohol consumption and the metabolic syndrome. J Clin Endocrinol Metab 2008;93(10): 3833-3838 https://doi.org/10.1210/jc.2007-2788
  33. Rantakomi SH, Laukkanen JA, Kurl S, Kauhanen J. Binge drinking and the progression of atherosclerosis in middle-aged men: an 11-year follow-up. Atherosclerosis 2009;205(1):266-271 https://doi.org/10.1016/j.atherosclerosis.2008.11.004
  34. Bagnardi V, Zatonski W, Scotti L, La Vecchia C, Corrao G. Does drinking pattern modify the effect of alcohol on the risk of coronary heart disease? Evidence from a meta-analysis. J Epidemiol Community Health 2008;62(7):615-619 https://doi.org/10.1136/jech.2007.065607
  35. Sull JW, Yi SW, Nam CM, Ohrr H. Binge drinking and mortality from all causes and cerebrovascular diseases in korean men and women: a Kangwha cohort study. Stroke 2009;40(9):2953-2958 https://doi.org/10.1161/STROKEAHA.109.556027
  36. Malyutina S, Bobak M, Kurilovitch S, Gafarov V, Simonova G, Nikitin Y, et al. Relation between heavy and binge drinking and all-cause and cardiovascular mortality in Novosibirsk, Russia: a prospective cohort study. Lancet 2002;360(9344):1448-1454 https://doi.org/10.1016/S0140-6736(02)11470-X

Cited by

  1. Twenty‐Five‐Year Alcohol Consumption Trajectories and Their Association With Arterial Aging: A Prospective Cohort Study vol.6, pp.2, 2017, https://doi.org/10.1161/JAHA.116.005288