The Korean Journal of Pain

  • 제25권1호
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  • Pages.1-6
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  • 2012
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
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Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test

  • Han, Yong-Ku (Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital) ;
  • Lee, Seong-Heon (Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital) ;
  • Jeong, Hye-Jin (Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital) ;
  • Kim, Min-Sun (Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital) ;
  • Yoon, Myung-Ha (Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital) ;
  • Kim, Woong-Mo (Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital)
  • 투고 : 2011.11.14
  • 심사 : 2011.12.05
  • 발행 : 2012.01.01
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초록

Background: Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain. Methods: Male Sprague Dawley rats were prepared for intrathecal catheterization. Pain was evoked by injection of formalin solution (5%, $50{\mu}l$) into the hind paw. Curcumin doses of 62.5, 125, 250, and $500{\mu}g$were delivered through an intrathecal catheter to examine the flinching responses. The $ED_{50}$ values (half-maximal effective dose) with 95% confidence intervals of curcumin for both phases of the formalin test were calculated from the dose-response lines fitted by least-squares linear regression on a log scale. Results: In rats with intrathecal administration of curcumin, the flinching responses were significantly decreased in both phases. The slope of the regression line was significantly different from zero only in phase 2, and the $ED_{50}$ value (95% confidence interval) of curcumin was $511.4{\mu}g$ (23.5-1126.5). There was no apparent abnormal behavior following the administration of curcumin. Conclusions: Intrathecal administration of curcumin decreased inflammatory pain in rats, and further investigation to elucidate the precise mechanism of spinal action of curcumin is warranted.

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참고문헌

  1. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med 2003; 9: 161-8.
  2. Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res 1991; 51: 813-9.
  3. Oetari S, Sudibyo M, Commandeur JN, Samhoedi R, Vermeulen NP. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Biochem Pharmacol 1996; 51: 39-45.
  4. Rao CV, Rivenson A, Simi B, Reddy BS. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res 1995; 55: 259-66.
  5. Sharma S, Kulkarni SK, Agrewala JN, Chopra K. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pharmacol 2006; 536: 256-61.
  6. Yeon KY, Kim SA, Kim YH, Lee MK, Ahn DK, Kim HJ, et al. Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. J Dent Res 2010; 89: 170-4.
  7. Zhao X, Xu Y, Zhao Q, Chen CR, Liu AM, Huang ZL. Curcumin exerts antinociceptive effects in a mouse model of neuropathic pain: Descending monoamine system and opioid receptors are differentially involved. Neuropharmacology 2011 [in press]
  8. Banerjee M, Tripathi LM, Srivastava VM, Puri A, Shukla R. Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat. Immunopharmacol Immunotoxicol 2003; 25: 213-24.
  9. Xu YX, Pindolia KR, Janakiraman N, Chapman RA, Gautam SC. Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells. Hematopathol Mol Hematol 1997-1998; 11: 49-62.
  10. Goel A, Boland CR, Chauhan DP. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett 2001; 172: 111-8.
  11. Yamamoto T, Nozaki-Taguchi N. The role of cyclooxygenase-1 and -2 in the rat formalin test. Anesth Analg 2002; 94: 962-7.
  12. Coderre TJ, Abbott FV, Sawynok J. The formalin test. In: Encyclopedia of pain. Edited by Schmidt RF, Willis WD. New York, Springer. 2007, pp 795-9.
  13. Sommer C, Sorkin LS. Cytokines as targets in the treatment of neuropathic pain. In: Encyclopedia of pain. Edited by Schmidt RF, Willis WD. New York, Springer. 2007, pp 518-20.
  14. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 17: 1031-6.
  15. Tallarida RJ. Drug synergism and dose-effect data analysis. Boca Raton (FL), Chapman and Hall/CRC. 2000.
  16. Puig S, Sorkin LS. Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity. Pain 1996; 64: 345-55.
  17. Mittal N, Joshi R, Hota D, Chakrabarti A. Evaluation of antihyperalgesic effect of curcumin on formalin-induced orofacial pain in rat. Phytother Res 2009; 23: 507-12.
  18. Tsai YM, Chien CF, Lin LC, Tsai TH. Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration. Int J Pharm 2011; 416: 331-8.
  19. Fairbanks CA. Spinal delivery of analgesics in experimental models of pain and analgesia. Adv Drug Deliv Rev 2003; 55: 1007-41.
  20. Fitzgibbon DR. Cancer pain: principles of management and pharmacotherapy. In: Bonica's management of pain. 4th ed. Edited by Fishman SM, Ballantyne JC, Rathmell JP. Philadelphia, Lippincott Williams & Wilkins. 2009, pp 583-603.
  21. Satoskar RR, Shah SJ, Shenoy SG. Evaluation of antiinflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol 1986; 24: 651-4.
  22. Deshpande SS, Lalitha VS, Ingle AD, Raste AS, Gadre SG, Maru GB. Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats. Toxicol Lett 1998; 95: 183-93.
  23. Kandarkar SV, Sawant SS, Ingle AD, Deshpande SS, Maru GB. Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies. Indian J Exp Biol 1998; 36: 675-9.

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  2. Evidence for the Participation of ATP-sensitive Potassium Channels in the Antinociceptive Effect of Curcumin vol.25, pp.4, 2012, https://doi.org/10.3344/kjp.2012.25.4.221
  3. Attenuation of Formalin-Induced Inflammatory Nociception by Propentofylline: Modulation of Glia vol.44, pp.6, 2012, https://doi.org/10.1007/s11062-012-9315-8
  4. HDAC and HAT Inhibitors Differently Affect Analgesia Mediated by Group II Metabotropic Glutamate Receptors vol.10, pp.1744-8069, 2014, https://doi.org/10.1186/1744-8069-10-68
  5. Curcumin Treatment Attenuates Pain and Enhances Functional Recovery after Incision vol.118, pp.6, 2014, https://doi.org/10.1213/ANE.0000000000000189
  6. The Attenuation of Pain Behavior and Serum COX-2 Concentration by Curcumin in a Rat Model of Neuropathic Pain vol.27, pp.3, 2014, https://doi.org/10.3344/kjp.2014.27.3.246
  7. The effect of intrathecal curcumin on mechanical allodynia in rats after L5 spinal nerve ligation vol.67, pp.Suppl, 2014, https://doi.org/10.4097/kjae.2014.67.S.S122
  8. Cyane-carvone, a Synthetic Derivative of Carvone, Inhibits Inflammatory Response by Reducing Cytokine Production and Oxidative Stress and Shows Antinociceptive Effect in Mice pp.1573-2576, 2014, https://doi.org/10.1007/s10753-014-9817-1
  9. Antinociceptive effects of curcumin in a rat model of postoperative pain vol.4, pp.1, 2014, https://doi.org/10.1038/srep04932
  10. Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis vol.5, pp.1, 2015, https://doi.org/10.1038/srep10278
  11. Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury vol.12, pp.6, 2016, https://doi.org/10.3892/etm.2016.3858
  12. Antinociceptive Effects of Prim-O-Glucosylcimifugin in Inflammatory Nociception via Reducing Spinal COX-2 vol.24, pp.4, 2016, https://doi.org/10.4062/biomolther.2015.168
  13. Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine vol.2017, pp.2314-6141, 2017, https://doi.org/10.1155/2017/4754701
  14. Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia vol.43, pp.4, 2018, https://doi.org/10.1111/jcpt.12703
  15. Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva ® ), nimesulide, and acetaminophen vol.6, pp.None, 2013, https://doi.org/10.2147/jpr.s42184
  16. Absence of clinical relationship between oxidized low density lipoproteins and diabetic peripheral neuropathy: a case control study vol.13, pp.None, 2012, https://doi.org/10.1186/1476-511x-13-32
  17. Synergistic effect of the interaction between curcumin and diclofenac on the formalin test in rats vol.21, pp.12, 2012, https://doi.org/10.1016/j.phymed.2014.06.015
  18. Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats vol.13, pp.1, 2012, https://doi.org/10.17085/apm.2018.13.1.82
  19. Antinociceptive role of neurotensin receptor 1 in rats with chemotherapy-induced peripheral neuropathy vol.33, pp.4, 2020, https://doi.org/10.3344/kjp.2020.33.4.318
  20. Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence vol.2021, pp.None, 2021, https://doi.org/10.1155/2021/8972074