Bulletin of the Korean Chemical Society

  • 제33권3호
  • /
  • Pages.897-900
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  • 2012
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Force-induced Unbinding Dynamics in a Multidimensional Free Energy Landscape

  • 투고 : 2011.11.30
  • 심사 : 2012.01.05
  • 발행 : 2012.03.20
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초록

We examined theory for force-induced unbinding on a two-dimensional free energy surface where the internal dynamics of biomolecules is coupled with the rupture process under constant tension f. We show that only if the transition state ensemble is narrow and activation barrier is high, the f-dependent rupture rate in the 2D potential surface can faithfully be described using an effective 1D energy profile.

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참고문헌

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