Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지
DOI QR코드

DOI QR Code

Rabbit maxillary sinus augmentation model with simultaneous implant placement: differential responses to the graft materials

  • Kim, Young-Sung (Department of Periodontics, Asan Medical Center) ;
  • Kim, Su-Hwan (Department of Periodontics, Asan Medical Center) ;
  • Kim, Kyoung-Hwa (Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry) ;
  • Jhin, Min-Ju (Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry) ;
  • Kim, Won-Kyung (Department of Periodontics, Asan Medical Center) ;
  • Lee, Young-Kyoo (Department of Periodontics, Asan Medical Center) ;
  • Seol, Yang-Jo (Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry) ;
  • Lee, Yong-Moo (Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry)
  • Received : 2012.10.12
  • Accepted : 2012.11.11
  • Published : 2012.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: This study was performed to establish an experimental rabbit model for single-stage maxillary sinus augmentation with simultaneous implant placement. Methods: Twelve mature New Zealand white rabbits were used for the experiments. The rabbit maxillary sinuses were divided into 3 groups according to sinus augmentation materials: blood clot (BC), autogenous bone (AB), and bovine-derived hydroxyapatite (BHA). Small titanium implants were simultaneously placed in the animals during the sinus augmentation procedure. The rabbits were sacrificed 4 and 8 weeks after surgery and were observed histologically. Histomorphometric analyses using image analysis software were also performed to evaluate the parameters related to bone regeneration and implant-bone integration. Results: The BC group showed an evident collapse of the sinus membrane and limited new bone formation around the original sinus floor at 4 and 8 weeks. In the AB group, the sinus membrane was well retained above the implant apex, and new bone formation was significant at both examination periods. The BHA group also showed retention of the elevated sinus membrane above the screw apex and evident new bone formation at both points in time. The total area of the mineral component (TMA) in the area of interest and the bone-to-implant contact did not show any significant differences among all the groups. In the AB group, the TMA had significantly decreased from 4 to 8 weeks. Conclusions: Within the limits of this study, the rabbit sinus model showed satisfactory results in the comparison of different grafting conditions in single-stage sinus floor elevation with simultaneous implant placement. We found that the rabbit model was useful for maxillary sinus augmentation with simultaneous implant placement.

Keywords

References

  1. Tatum H Jr. Maxillary and sinus implant reconstructions. Dent Clin North Am 1986;30:207-29.
  2. Summers RB. A new concept in maxillary implant surgery: the osteotome technique. Compendium 1994;15:152, 154-6, 158.
  3. Rosen PS, Summers R, Mellado JR, Salkin LM, Shanaman RH, Marks MH, et al. The bone-added osteotome sinus floor elevation technique: multicenter retrospective report of consecutively treated patients. Int J Oral Maxillofac Implants 1999;14:853-8.
  4. Fugazzotto PA. The modified trephine/osteotome sinus augmentation technique: technical considerations and discussion of indications. Implant Dent 2001;10:259-64.
  5. Chen L, Cha J. An 8-year retrospective study: 1,100 patients receiving 1,557 implants using the minimally invasive hydraulic sinus condensing technique. J Periodontol 2005; 76:482-91.
  6. Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg 1980;38: 613-6.
  7. Lazzara RJ. The sinus elevation procedure in endosseous implant therapy. Curr Opin Periodontol 1996;3:178-83.
  8. Peleg M, Mazor Z, Chaushu G, Garg AK. Sinus floor augmentation with simultaneous implant placement in the severely atrophic maxilla. J Periodontol 1998;69:1397-403.
  9. Zitzmann NU, Scharer P. Sinus elevation procedures in the resorbed posterior maxilla. Comparison of the crestal and lateral approaches. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:8-17.
  10. Jensen OT, Shulman LB, Block MS, Iacono VJ. Report of the Sinus Consensus Conference of 1996. Int J Oral Maxillofac Implants 1998;13 Suppl:11-45.
  11. Peleg M, Mazor Z, Garg AK. Augmentation grafting of the maxillary sinus and simultaneous implant placement in patients with 3 to 5 mm of residual alveolar bone height. Int J Oral Maxillofac Implants 1999;14:549-56.
  12. Mayfield LJ, Skoglund A, Hising P, Lang NP, Attstrom R. Evaluation following functional loading of titanium fixtures placed in ridges augmented by deproteinized bone mineral. A human case study. Clin Oral Implants Res 2001; 12:508-14.
  13. Fugazzotto PA. Immediate implant placement following a modified trephine/osteotome approach: success rates of 116 implants to 4 years in function. Int J Oral Maxillofac Implants 2002;17:113-20.
  14. Wallace SS, Froum SJ. Effect of maxillary sinus augmentation on the survival of endosseous dental implants. A systematic review. Ann Periodontol 2003;8:328-43.
  15. Emmerich D, Att W, Stappert C. Sinus floor elevation using osteotomes: a systematic review and meta-analysis. J Periodontol 2005;76:1237-51.
  16. Ferrigno N, Laureti M, Fanali S. Dental implants placement in conjunction with osteotome sinus floor elevation: a 12-year life-table analysis from a prospective study on 588 ITI implants. Clin Oral Implants Res 2006;17:194-205.
  17. Watanabe K, Niimi A, Ueda M. Autogenous bone grafts in the rabbit maxillary sinus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:26-32.
  18. Wada K, Niimi A, Watanabe K, Sawai T, Ueda M. Maxillary sinus floor augmentation in rabbits: a comparative histologic-histomorphometric study between rhBMP-2 and autogenous bone. Int J Periodontics Restorative Dent 2001; 21:252-63.
  19. Butterfield KJ, Bennett J, Gronowicz G, Adams D. Effect of platelet-rich plasma with autogenous bone graft for maxillary sinus augmentation in a rabbit model. J Oral Maxillofac Surg 2005;63:370-6.
  20. Ohya M, Yamada Y, Ozawa R, Ito K, Takahashi M, Ueda M. Sinus floor elevation applied tissue-engineered bone. Comparative study between mesenchymal stem cells/platelet-rich plasma (PRP) and autogenous bone with PRP complexes in rabbits. Clin Oral Implants Res 2005;16:622-9.
  21. Rahmani M, Shimada E, Rokni S, Deporter DA, Adegbembo AO, Valiquette N, et al. Osteotome sinus elevation and simultaneous placement of porous-surfaced dental implants: a morphometric study in rabbits. Clin Oral Implants Res 2005;16:692-9.
  22. Sun XJ, Zhang ZY, Wang SY, Gittens SA, Jiang XQ, Chou LL. Maxillary sinus floor elevation using a tissue-engineered bone complex with OsteoBone and bMSCs in rabbits. Clin Oral Implants Res 2008;19:804-13.
  23. Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. The Sage-Schliff (sawing and grinding) technique. J Oral Pathol 1982;11:318-26.
  24. Dannan A, Alkattan F. Animal models in periodontal research: a mini-review of the literature. Internet J Vet Med [Internet]. 2008 [cited 2009 Aug 12];5:[about 3 p.]. Available from: http://www.ispub.com/journal/the-internet-journal-of-veterinary-medicine/volume-5-number-1/animal-models-in-periodontal-research-a-mini-review-of-the-literature.html#sthash.Jpt0qK5R.dpbs.
  25. Schlegel AK, Donath K. BIO-OSS: a resorbable bone substitute? J Long Term Eff Med Implants 1998;8:201-9.
  26. McAllister BS, Margolin MD, Cogan AG, Buck D, Hollinger JO, Lynch SE. Eighteen-month radiographic and histologic evaluation of sinus grafting with anorganic bovine bone in the chimpanzee. Int J Oral Maxillofac Implants 1999;14:361-8.
  27. Handschel J, Simonowska M, Naujoks C, Depprich RA, Ommerborn MA, Meyer U, et al. A histomorphometric meta-analysis of sinus elevation with various grafting materials. Head Face Med 2009;5:12.
  28. Lee YM, Shin SY, Kim JY, Kye SB, Ku Y, Rhyu IC. Bone reaction to bovine hydroxyapatite for maxillary sinus floor augmentation: histologic results in humans. Int J Periodontics Restorative Dent 2006;26:471-81.
  29. Hallman M, Cederlund A, Lindskog S, Lundgren S, Sennerby L. A clinical histologic study of bovine hydroxyapatite in combination with autogenous bone and fibrin glue for maxillary sinus floor augmentation. Results after 6 to 8 months of healing. Clin Oral Implants Res 2001;12:135-43.
  30. Johansson CB, Albrektsson T. A removal torque and histomorphometric study of commercially pure niobium and titanium implants in rabbit bone. Clin Oral Implants Res 1991;2:24-9.

Cited by

  1. Intracellular delivery of cell-penetrating peptide-transcriptional factor fusion protein and its role in selective osteogenesis vol.9, pp.None, 2014, https://doi.org/10.2147/ijn.s55433
  2. Comparison of alveolar ridge preservation methods using three-dimensional micro-computed tomographic analysis and two-dimensional histometric evaluation vol.44, pp.2, 2012, https://doi.org/10.5624/isd.2014.44.2.143
  3. Masticatory biomechanics in the rabbit: a multi-body dynamics analysis vol.11, pp.99, 2012, https://doi.org/10.1098/rsif.2014.0564
  4. Long-term results of new deproteinized bovine bone material in a maxillary sinus graft procedure vol.44, pp.5, 2012, https://doi.org/10.5051/jpis.2014.44.5.259
  5. Goat Model for Direct Visualizing the Effectiveness of Detaching Sinus Mucosa in Real Time During Crestal Maxillary Sinus Floor Elevation vol.43, pp.4, 2017, https://doi.org/10.1563/aaid-joi-d-16-00102
  6. Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits vol.47, pp.2, 2012, https://doi.org/10.5051/jpis.2017.47.2.86
  7. Diagnostic imaging modalities and surgical anatomy of the temporomandibular joint in rabbits vol.52, pp.1, 2012, https://doi.org/10.1177/0023677217702178
  8. Section Plane Effects on Morphometric Values of Microcomputed Tomography vol.2019, pp.None, 2012, https://doi.org/10.1155/2019/7905404
  9. A retrospective study of implants placed following 1‐stage or 2‐stage maxillary sinus floor augmentation by the lateral window technique performed on residual bone of <4 mm: Resul vol.91, pp.2, 2012, https://doi.org/10.1002/jper.19-0066
  10. Maxillary Sinus Floor Augmentation with Autogenous Bone Graft Alone Compared with Alternate Grafting Materials: a Systematic Review and Meta-Analysis Focusing on Histomorphometric Outcome vol.11, pp.3, 2012, https://doi.org/10.5037/jomr.2020.11302
  11. Effectiveness of strontium‐doped brushite, bovine‐derived hydroxyapatite and synthetic hydroxyapatite in rabbit sinus augmentation with simultaneous implant installation vol.108, pp.8, 2012, https://doi.org/10.1002/jbm.b.34675