Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Herbal Medicines from China and Vietnam with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (VIII)

중국.베트남 약용식물의 최종당화산물 생성저해활성 검색(VIII)

  • Choi, So-Jin (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division) ;
  • Song, Yoo Jin (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division) ;
  • Kim, Young Sook (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division) ;
  • Kim, Joo Hwan (Department of Life Science, Gachon University) ;
  • Hang, Sun (Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Sciences) ;
  • Tran, The Bach (Department of Botany, Institute of Ecology and Biological Resources, Vietnamese Academy of Science and Technology) ;
  • Kim, Jin Sook (Korean Medicine-Based Herbal Drug Research Group, Herbal Medicine Research Division)
  • 최소진 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 송유진 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 김영숙 (한국한의학연구원 한약연구본부 한의신약연구그룹) ;
  • 김주환 (가천대학교 생명과학과) ;
  • ;
  • ;
  • 김진숙 (한국한의학연구원 한약연구본부 한의신약연구그룹)
  • Received : 2012.10.20
  • Accepted : 2012.11.06
  • Published : 2012.12.31
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Abstract

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 62 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 5 herbal medicines ($IC_{50}$ < $5{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Albizia odoratissima (twigs and leaves), Rhododendron spinuliferum (twigs and leaves), Dioscorea cirrhosa (stems and leaves), Illicium verum (stems and leaves) and Aglaia perviridis (stems and leaves), showed more potent inhibitory activity (approximately 16-26 fold) than the positive control aminoguanidine ($IC_{50}=76.47{\mu}g/ml$).

Keywords

References

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