참고문헌
- Odom DT, Dowell RD, Jacobsen ES, Gordon W, Danford TW, MacIsaac KD, et al. Tissue-specific transcriptional regulation has diverged significantly between human and mouse. Nat Genet 2007;39:730-2. https://doi.org/10.1038/ng2047
- Perel P, Roberts I, Sena E, Wheble P, Briscoe C, Sandercock P, et al. Comparison of treatment effects between animal experiments andclinical trials: systematic review. BMJ 2007;334:197. https://doi.org/10.1136/bmj.39048.407928.BE
- Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7. https://doi.org/10.1126/science.282.5391.1145
- Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76. https://doi.org/10.1016/j.cell.2006.07.024
- Urbach A, Schuldiner M, Benvenisty N. Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells. Stem Cells 2004;22:635-41. https://doi.org/10.1634/stemcells.22-4-635
- Mateizel I, De Temmerman N, Ullmann U, Cauffman G, Sermon K, Van de Velde H, et al. Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders. Hum Reprod 2006;21:503-11. https://doi.org/10.1093/humrep/dei345
- Gilbert DM. The future of human embryonic stem cell research: addressing ethical conflict with responsible scientific research. Med Sci Monit 2004;10:RA99-103.
- Saha K, Jaenisch R. Technical challenges in using human induced pluripotent stem cells to model disease. Cell stem cell 2009;5:584-95. https://doi.org/10.1016/j.stem.2009.11.009
- Collin J, Lako M. Concise review: putting a finger on stem cell biology: zinc finger nuclease-driven targeted genetic editing in human pluripotent stem cells. Stem Cells 2011;29:1021-33. https://doi.org/10.1002/stem.658
- Lui KO, Waldmann H, Fairchild PJ. Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy. Curr Stem Cell Res Ther 2009;4:70-80. https://doi.org/10.2174/157488809787169093
- Hochedlinger K, Jaenisch R. Nuclear reprogramming and pluripotency. Nature 2006;441:1061-7. https://doi.org/10.1038/nature04955
- Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature 1997;385:810-3. https://doi.org/10.1038/385810a0
- Noggle S, Fung HL, Gore A, Martinez H, Satriani KC, Prosser R, et al. Human oocytes reprogram somatic cells to a pluripotent state. Nature 2011;478:70-5. https://doi.org/10.1038/nature10397
- Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 2005;309:1369-73. https://doi.org/10.1126/science.1116447
- Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72. https://doi.org/10.1016/j.cell.2007.11.019
- Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, et al. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 2008;133:250-64. https://doi.org/10.1016/j.cell.2008.03.028
- Utikal J, Maherali N, Kulalert W, Hochedlinger K. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci 2009;122:3502-10. https://doi.org/10.1242/jcs.054783
- Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, et al. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A 2009;106:15720-5. https://doi.org/10.1073/pnas.0908450106
- Banito A, Gil J. Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep 2010;11:353-9. https://doi.org/10.1038/embor.2010.47
- Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol 2008;26:101-6. https://doi.org/10.1038/nbt1374
- Kim JB, Sebastiano V, Wu G, Arauzo-Bravo MJ, Sasse P, Gentile L, et al. Oct4-induced pluripotency in adult neural stem cells. Cell 2009; 136:411-9. https://doi.org/10.1016/j.cell.2009.01.023
- Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20. https://doi.org/10.1126/science.1151526
- Si-Tayeb K, Noto FK, Sepac A, Sedlic F, Bosnjak ZJ, Lough JW, et al. Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. BMC Dev Biol 2010;10:81. https://doi.org/10.1186/1471-213X-10-81
- Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell stem cell 2010;7:618-30. https://doi.org/10.1016/j.stem.2010.08.012
- Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell stem cell 2011;8:376-88. https://doi.org/10.1016/j.stem.2011.03.001
- Kim D, Kim CH, Moon JI, Chung YG, Chang MY, Han BS, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell stem cell 2009;4:472-6. https://doi.org/10.1016/j.stem.2009.05.005
- Shi Y, Desponts C, Do JT, Hahm HS, Scholer HR, Ding S. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell stem cell 2008;3:568-74. https://doi.org/10.1016/j.stem.2008.10.004
- Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 2008;26:795-7. https://doi.org/10.1038/nbt1418
- Hochedlinger K, Plath K. Epigenetic reprogramming and induced pluripotency. Development 2009;136:509-23. https://doi.org/10.1242/dev.020867
- Efe JA, Hilcove S, Kim J, Zhou H, Ouyang K, Wang G, et al. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol 2011;13:215-22. https://doi.org/10.1038/ncb2164
- Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, et al. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A 2011;108:7838-43. https://doi.org/10.1073/pnas.1103113108
- Szabo E, Rampalli S, Risueno RM, Schnerch A, Mitchell R, Fiebig- Comyn A, et al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature 2010;468:521-6. https://doi.org/10.1038/nature09591
- Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010;463 1035-41. https://doi.org/10.1038/nature08797
- Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton SA, et al. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell stem cell 2011;9:113-8. https://doi.org/10.1016/j.stem.2011.07.002
- Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 2011;476:228-31. https://doi.org/10.1038/nature10323
- Pan G, Wang T, Yao H, Pei D. Somatic cell reprogramming for regenerative medicine: SCNT vs. iPS cells. BioEssays : news and reviews in molecular, cellular and developmental biology. 2012.
- Han DW, Tapia N, Hermann A, Hemmer K, Hoing S, Arauzo-Bravo MJ, et al. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell stem cell 2012;10:465-72. https://doi.org/10.1016/j.stem.2012.02.021
- Lujan E, Chanda S, Ahlenius H, Sudhof TC, Wernig M. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A 2012;109:2527-32. https://doi.org/10.1073/pnas.1121003109
- Robinton DA, Daley GQ. The promise of induced pluripotent stem cells in research and therapy. Nature 2012;481:295-305. https://doi.org/10.1038/nature10761
- Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, et al. Disease-specific induced pluripotent stem cells. Cell 2008;134:877-86. https://doi.org/10.1016/j.cell.2008.07.041
- Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 2008;321:1218-21. https://doi.org/10.1126/science.1158799
- Urbach A, Bar-Nur O, Daley GQ, Benvenisty N. Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell stem cell 2010;6407-11.
- Carvajal-Vergara X, Sevilla A, D'Souza SL, Ang YS, Schaniel C, Lee DF, et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 2010;465:808-12. https://doi.org/10.1038/nature09005
- Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 2007;318:1920-3. https://doi.org/10.1126/science.1152092
- Raya A, Rodriguez-Piza I, Guenechea G, Vassena R, Navarro S, Barrero MJ, et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature 2009;460:53-9. https://doi.org/10.1038/nature08129
- Chang T, Zheng W, Tsark W, Bates S, Huang H, Lin RJ, et al. Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient. Stem Cells 2011;29:2090-3 https://doi.org/10.1002/stem.749
- Yazawa M, Hsueh B, Jia X, Pasca AM, Bernstein JA, Hallmayer J, et al. Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 2011;471:230-4. https://doi.org/10.1038/nature09855
- Grskovic M, Javaherian A, Strulovici B, Daley GQ. Induced pluripotent stem cells--opportunities for disease modelling and drug discovery. Nat Rev Drug Discov 2011;10:915-29.
- Stadtfeld M, Hochedlinger K. Induced pluripotency: history, mechanisms, and applications. Genes Dev 2010 15;24:2239-63. https://doi.org/10.1101/gad.1963910
- Tiscornia G, Vivas EL, Belmonte JC. Diseases in a dish: modeling human genetic disorders using induced pluripotent cells. Nat Med 2011;17:1570-6. https://doi.org/10.1038/nm.2504
- Itzhaki I, Maizels L, Huber I, Zwi-Dantsis L, Caspi O, Winterstern A, et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature 2011;471:225-9. https://doi.org/10.1038/nature09747
- Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011;473:221-5. https://doi.org/10.1038/nature09915
- Jang J, Kang HC, Kim HS, Kim JY, Huh YJ, Kim DS, et al. Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients. Ann Neurol 2011;70:402-9. https://doi.org/10.1002/ana.22486