Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Anti-Inflammatory Components of Platycodi Radix Butanol Fractions

길경(Platycodi Radix) Butanol 분획물의 항염증 활성 성분

  • Kim, Sung-Yeun (Dept. of Food Science, Seoul Woman's University) ;
  • Lee, Eun-Bang (Natureal Product Research Institute, Seoul National University) ;
  • Jeong, Eun-Ja (Dept. of Food & Nutrition Science, Eulji University)
  • 김성연 (서울여자대학교 대학원 식품과학과) ;
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 정은자 (을지대학교 보건산업대학 식품영양학과)
  • Received : 2012.10.16
  • Accepted : 2012.12.11
  • Published : 2012.12.31
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Abstract

This study was conducted to examine the development of a new anti-inflammatory substance with potent anti-inflammatory activities that was derived from the Platycodi Radix butanol fraction. To accomplish this, the chemical structures and anti-inflammatory activities of the components were elucidated. Upon column chromatography of the tertiary subfraction, fractions 8-4-1 and 8-4-2 were identified as platycodin D and D3, respectively, following recrystallization, based on melting point (MP), infrared (IR), and positive fast atom bombardment (FAB)-mass and nuclear magnetic resonance (NMR) spectral data. Platycodin D and D3 exhibited strong anti-inflammatory activities in rats when administerd at oral doses of 12 mg/kg and 36 mg/kg, p.o., respectively. Platycodin D and D3 induced inhibitory effects on capillary vascular permeability in rats at oral doses of 16 mg/kg and 24 mg/kg, p.o., respectively, and potent inhibition of leukocyte emigration in a carboxymethyl cellulose (CMC)-pouch when administered at doses of 3 mg/rat and 7 mg/rat, s.c., respectively. These results verified the high antiinflammatory potency of the platycodin D and D3 components in Platycodi Radix.

Keywords

References

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