Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Propofol and Remifentanil Combination Anesthesia on Intraocular Pressure and Hemodynamic Parameters in Dogs

개에서 Propofol/Remifentanil 병용마취 후 안압 및 혈역학 변화

  • Lim, Tae-Sun (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Yun, Sung-Ho (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Ji-Hee (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Kwon, Young-Sam (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Jang, Kwang-Ho (Department of Surgery, College of Veterinary Medicine, Kyungpook National University)
  • Accepted : 2012.12.11
  • Published : 2012.12.31
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Abstract

The objective of this study was to determine the effect of propofol and remifentanil combination on hemodynamics and intraocular pressure (IOP), and to compare with those of isoflurane in beagle dogs. Fourteen clinically healthy beagle dogs were divided randomly into 2 groups and each group was consisted with 7 dogs. Anesthetic agents were propofol (0.2 mg/kg/min) plus remifentanil ($0.5{\mu}g/kg/min$, 1% solution in standard saline) in one group (group PRP) and 3% isoflurane in the other group (group ISF). Anesthesia was maintained for 90 min in the both groups. IOP, blood pressure, heart rate and blood gas values (pH, $PaCO_2$, $PaO_2$, $SaO_2$, $tCO_2$, ${HCO_3}^-$) were recorded at 5, 10, 15, 30, 45, 60, 75 and 90 min in the both groups. IOP values in both eyes were significantly decreased in group PRP compared with those in group ISF. but there were no significant differences between two eyes in each group. Systolic, diastolic and mean blood pressures were significantly decreased in group PRP within the normal range. There were no differences between groups in all blood gas parameters. In this study, propofol and remifentanil combination could provide stable IOP and blood pressure compared with isoflurane.

본 실험에서는 propofol과 remifentanil 병용 마취법 사용 시 안압 및 혈액학적 변화를 측정하고 isoflurane 마취 결과와 비교하였다. 건강한 14마리의 비글견을 7마리씩 2군 (PRP군, ISF군)으로 나누었으며 PRP군은 마취 도입 10분 전에 acepromazine (0.05 mg/kg, IV)으로 전마취제 투여하고 atracurium 0.1 mg/kg 투여 후, propofol (5 mg/kg, IV)으로 마취 유도하였다. 마취 유지에는 propofol (0.2 mg/kg/min)과 remifentanil ($0.5{\mu}g/kg/min$)을 사용하였다. ISF군에서는 propofol (5~7 mg/kg, IV)로 마취를 유도하고, isoflurane 흡입마취법으로 마취를 유지하였다. 초기 isoflurane 농도를 3%으로 유지하다가 마취가 안정된 후 1.9%로 낮추어 유지 하였다. 모든 군에서 간헐적인 100% 양압 호흡을 사용해 $CO_2$는 38에서 45 mmHg사이를 유지하고 $SpO_2$는 95에서 100사이를 유지하였다. 총 마취 시간은 90분이었으며 안압, 혈압, 심박수를 각각 5, 10, 15, 30, 45, 60, 75, 90에 측정을 하였다. 실험 결과 propofol과 remifentanil 병용마취법이 isoflurane 흡입마취법 보다 안정적으로 안압과 혈압을 낮출 수 있었다.

Keywords

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