생명과학회지 (Journal of Life Science)

  • 제22권1호
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  • Pages.1-6
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  • 2012
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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비만 마우스 간의 항산화시스템에 대한 바나듐 함유 제주지하수의 증강효과

Consumption of Jeju Ground Water Containing Vanadium Components Enhances Hepatic Antioxidant Defense Systems in ob/ob Mice

  • 투고 : 2011.10.10
  • 심사 : 2011.10.26
  • 발행 : 2012.01.30
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초록

비만 마우스의 산화적 스트레스에 대해 바나듐 함유 제주 지하수에 대한 연구로서, 제주 지하수는 수도수 처리군보다 비만 마우스 간의 과산화 지질을 감소시켰으며, superoxide dismutase, catalase, 그리고 glutathione peroxidase의 단백질 발현 및 활성 그리고 환원형 glutathione 양을 증가 시켰다. 제주 지하수는 항산화 효소의 전사 인자인 erythroid transcription factor NF-E2 (Nrf2)의 인산화형 단백질 발현을 증가시켰다. 이로서 제주 지하수는 Nrf2의 활성화를 통하여 항산화 효소시스템을 증가시켰다.

The present study examined the effects of consumption of Jeju ground water containing vanadium components on oxidative stress in obese (ob/ob) mice. Intake of Jeju ground water decreased the generation of oxidative stress induced-lipid peroxidation in the liver of ob/ob mice It also enhanced the enzymatic antioxidant defense system by increasing the protein expression and activity of superoxide dismutase, catalase, and glutathione peroxidase in liver tissues. Jeju ground water intake also upregulated the intracellular content of reduced glutathione. The induction of antioxidant enzyme expression by consumption of Jeju ground water was mediated by the erythroid transcription factor NF-E2 (Nrf2). Increased nuclear expression of phospho Nrf2 was observed in ob/ob mouse liver cells following ntake of Jeju ground water. These results suggest that consumption of Jeju ground water stimulated the antioxidant defense system in the livers of ob/ob mice via induction of Nrf2.

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참고문헌

  1. Capel, I. D. and H. M. Dorrell. 1984. Abnormal antioxidant defence in some tissues of congenitally obese mice. Biochem. J. 219, 41-49.
  2. Christophersen, B. O. 1969. Reduction of linolenic acid hydroperoxide by a glutathione peroxidase. Biochim. Biophys. Acta. 176, 463-470. https://doi.org/10.1016/0005-2760(69)90213-6
  3. Christophersen, B. O. 1969. Reduction of X-ray-induced DNA and thymine hydroperoxides by rat liver glutathione peroxidase. Biochim. Biophys. Acta. 186, 387-389. https://doi.org/10.1016/0005-2787(69)90017-3
  4. de Oliveira, C. P., V. M. de Lima, F. I. Simplicio, F. G. Soriano, E. S. de Mello, H. P. de Souza, V. A. Alves, F. R. Laurindo, F. J. Carrilho, and M. G. de Oliveira. 2008. Prevention and reversion of nonalcoholic steatohepatitis in OB/OB mice by S-nitroso-N-acetylcysteine treatment. J. Am. Coll. Nutr. 27, 299-305. https://doi.org/10.1080/07315724.2008.10719703
  5. Fardet, A., R. Llorach, J. F. Martin, C. Besson, B. Lyan, E. Pujos-Guillot, and A. Scalbert. 2008. A liquid chromatography- quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets. J. Proteome. Res. 7, 2388-2398. https://doi.org/10.1021/pr800034h
  6. Ha, D. B., M. J. Kim, H. J. Joo, J. H. Cho, S. J. Bing, Y. K. Lim, J. W. Hyun, and Y. H. Jee. 2011. Immune activation of Jeju water containing vanadium on peripheral immunocytes, of Low dose gamma rays-irradiated mice. Korean J. Vet. Publ. Health 35, 49-59.
  7. Hamelet, J., K. Demuth, J. L. Paul, J. M. Delabar, and N. Janel. 2007. Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice. J. Hepatol. 46, 151-159. https://doi.org/10.1016/j.jhep.2006.07.028
  8. Hong, J. H. and I. S. Lee. 2009. Effects of Artemisia capillaris ethyl acetate fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice. Chem. Biol.Interact. 179, 88-93. https://doi.org/10.1016/j.cbi.2008.12.002
  9. Kim, A. D., K. A. Kang, R. Zhang, C. M. Lim, Y. E. Jee, N. H. Lee, H. J. You, K. S. Ko, and J. W. Hyun. 2010. Reactive Oxygen Species Scavenging Effects of Jeju Waters Containing Vanadium Components. Cancer Prev. Res. 15, 111-117.
  10. Kim, A. D., K. A. Kang, R. Zhang, M. J. Piao, S. M. Kim, Y. E. Jee, N. H. Lee, H. J. You, K. S. Ko, and J. W. Hyun. 2010. Effects of Jeju Water Containing Vanadium on Antioxidant Enzymes in vitro. Cancer Prev. Res. 15, 262-267.
  11. Kim, A. D., K. A. Kang, R. Zhang, M. J. Piao, S. M. Kim, Y. E. Jee, N. H. Lee, H. J. You, K. S. Ko, and J. W. Hyun. 2011. Antioxidant Enzyme-Enhancing Effects of Jeju Water Containing Vanadium in vivo. Cancer Prev. Res. 16, 58-64.
  12. Liu, X. M., K. J. Peyton, A. R. Shebib, H. Wang, and W. Durante. 2011. Compound C stimulates heme oxygenase-1 gene expression via the Nrf2-ARE pathway to preserve human endothelial cell survival. Biochem. Pharmacol. 82, 371-379. https://doi.org/10.1016/j.bcp.2011.05.016
  13. Motohashi, H. and M. Yamamoto. 2004. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10, 549-557. https://doi.org/10.1016/j.molmed.2004.09.003
  14. Park, H. J., D. A. DiNatale, M. Y. Chung, Y. K. Park, J. Y. Lee, S. I. Koo, M. O'Connor, J. E. Manautou, and R. S. Bruno. 2011. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J. Nutr. Biochem. 22, 393-400. https://doi.org/10.1016/j.jnutbio.2010.03.009
  15. Preet, A., B. L. Gupta, P. K. Yadava, and N. Z. Baquer. 2005. Efficacy of lower doses of vanadium in restoring altered glucose metabolism and antioxidant status in diabetic rat lenses. J. Biosci. 30, 221-230. https://doi.org/10.1007/BF02703702
  16. Prohaska, J. R., Jr. L. E. Wittmers, and E. W. Haller. 1988. Influence of genetic obesity, food intake and adrenalectomy in mice on selected trace element-dependent protective enzymes. J. Nutr. 118, 739-746.
  17. Raval, J., S. Lyman, T. Nitta, D. Mohuczy, J. J. Lemasters, J. S. Kim, and K. E. Behrns. 2006. Basal reactive oxygen species determine the susceptibility to apoptosis in cirrhotic hepatocytes. Free Radic. Biol. Med. 41, 1645-1654. https://doi.org/10.1016/j.freeradbiomed.2006.07.023
  18. Rehder, D. 2003. Biological and medicinal aspects of vanadium. Inorg. Chem. Commun. 6, 604-617. https://doi.org/10.1016/S1387-7003(03)00050-9
  19. Roberts, C. K., R. J. Barnard, R. K. Sindhu, M. Jurczak, A. Ehdaie, and N. D. Vaziri. 2006. Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Metabolism 55, 928-934. https://doi.org/10.1016/j.metabol.2006.02.022
  20. Sutherland, W. H., P. J. Manning, R. J. Walker, S. A. de Jong, A. R. Ryalls, and E. A. Berry. 2007. Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. Obesity 15, 386-391. https://doi.org/10.1038/oby.2007.546
  21. Tauskela, J. S., K. Hewitt, L. P. Kang, T. Comas, T. Gendron, A. Hakim, M. Hogan, J. Durkin, and P. Morley. 2000. Evaluation of glutathione-sensitive fluorescent dyes in cortical culture. Glia 30, 329-341. https://doi.org/10.1002/(SICI)1098-1136(200006)30:4<329::AID-GLIA20>3.0.CO;2-R
  22. Tunali, S. and R. Yanardag. 2006. Effect of vanadyl sulfate on the status of lipid parameters and on stomach and spleen tissues of streptozotocin-induced diabetic rats. Pharmacol. Res. 53, 271-277. https://doi.org/10.1016/j.phrs.2005.12.004
  23. Yang, S., H. Zhu, Y. Li, H. Lin, K. Gabrielson, M. A. Trush, and A. M. Diehl. 2000. Mitochondrial adaptations to obesity- related oxidant stress. Arch. Biochem. Biophys. 378, 259-268. https://doi.org/10.1006/abbi.2000.1829
  24. Zavalza-Gomez, A. B. 2011. Obesity and oxidative stress: a direct link to preeclampsia? Arch. Gynecol. Obstet. 283, 415-422. https://doi.org/10.1007/s00404-010-1753-1

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