Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model

  • Seo, Jong-Bae (R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center) ;
  • Jeong, Jae-Yeon (Marine Biotechnology Research Center, Korea Ocean Research & Development Institute) ;
  • Park, Jae-Young (R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center) ;
  • Jun, Eun-Mi (R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center) ;
  • Lee, Sang-Ik (Institute of Traditional Medicine & Bioscience, Daejeon University) ;
  • Choe, Sung-Sik (R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center) ;
  • Park, Do-Yang (R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center) ;
  • Choi, Eun-Wook (R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center) ;
  • Seen, Dong-Seung (R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center) ;
  • Lim, Jong-Soon (Institute of Traditional Medicine & Bioscience, Daejeon University) ;
  • Lee, Tae-Gyu (R&D Center, BRN Science Co., Ltd., Biotechnology Incubation Center)
  • Received : 2011.08.11
  • Accepted : 2011.11.18
  • Published : 2012.01.31
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Abstract

The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines TNF-${\alpha}$, IL-6, and IL-$1{\beta}$ were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheumatoid arthritis.

Keywords

References

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