Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Diagnosis and constitutional and laboratory features of Korean girls referred for precocious puberty

  • Kim, Doosoo (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Cho, Sung-Yoon (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Maeng, Se-Hyun (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Yi, Eun Sang (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jung, Yu Jin (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Sung Won (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sohn, Young Bae (Department of Medical Genetics, Ajou University Hospital) ;
  • Jin, Dong-Kyu (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 투고 : 2012.08.23
  • 심사 : 2012.10.23
  • 발행 : 2012.12.15
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초록

Purpose: Precocious puberty is defined as breast development before the age of 8 years in girls. The present study aimed to reveal the diagnosis of Korean girls referred for precocious puberty and to compare the constitutional and endocrinological features among diagnosis groups. Methods: The present study used a retrospective chart review of 988 Korean girls who had visited a pediatric endocrinology clinic from 2006 to 2010 for the evaluation of precocious puberty. Study groups comprised fast puberty, true precocious puberty (PP), pseudo PP, premature thelarche, and control. We determined the height standard deviation score (HSDS), weight standard deviation score (WSDS), and body mass index standard deviation score (BMISDS) of each group using the published 2007 Korean growth charts. Hormone tests were performed at our outpatient clinic. Results: The PP groups comprised fast puberty (67%), premature thelarche (17%), true PP (15%), and pseudo PP (1%). Advanced bone age and levels of estradiol, basal luteinizing hormone (LH), and peak LH after gonadotropin-releasing hormone stimulation testing were significantly high in the fast puberty and true PP groups compared with the control group. HSDS, WSDS, and BMISDS were significantly higher in the true PP group than in the control group (P<0.05). Conclusion: The frequent causes of PP were found to be fast puberty, true PP, and premature thelarche. Furthermore, BMISDS were significantly elevated in the true PP group. Therefore, we emphasize the need for regular follow-up of girls who are heavier or taller than others in the same age group.

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참고문헌

  1. Carel JC, Lahlou N, Roger M, Chaussain JL. Precocious puberty and statural growth. Hum Reprod Update 2004;10:135-47. https://doi.org/10.1093/humupd/dmh012
  2. Kliegman RM, Stanton B, St. Geme J, Schor N, Behrman RE. Nelson textbook of pediatrics. 19th ed. Philadelphia: Elsevier Saunders, 2011:1887-9.
  3. Largo RH, Prader A. Pubertal development in Swiss girls. Helv Paediatr Acta 1983;38:229-43.
  4. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969;44:291-303. https://doi.org/10.1136/adc.44.235.291
  5. Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, et al. Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 1997;99:505-12. https://doi.org/10.1542/peds.99.4.505
  6. Kaplowitz PB, Oberfield SE. Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment. Drug and Therapeutics and Executive Committees of the Lawson Wilkins Pediatric Endocrine Society. Pediatrics 1999;104(4 Pt 1):936-41. https://doi.org/10.1542/peds.104.4.936
  7. Park YJ, Moon CM, Yoo HJ. A study of factors influencing advanced puberty. Korean J Pediatr 2010;53:146-51. https://doi.org/10.3345/kjp.2010.53.2.146
  8. Hauspie RC, Vercauteren M, Susanne C. Secular changes in growth and maturation: an update. Acta Paediatr Suppl 1997;423:20-7.
  9. Herman-Giddens ME, Kaplowitz PB, Wasserman R. Navigating the recent articles on girls' puberty in pediatrics: what do we know and where do we go from here? Pediatrics 2004;113:911-7. https://doi.org/10.1542/peds.113.4.911
  10. Mouritsen A, Aksglaede L, Sorensen K, Mogensen SS, Leffers H, Main KM, et al. Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty. Int J Androl 2010;33:346-59. https://doi.org/10.1111/j.1365-2605.2010.01051.x
  11. Wang RY, Needham LL, Barr DB. Effects of environmental agents on the attainment of puberty: considerations when assessing exposure to environmental chemicals in the National Children's Study. Environ Health Perspect 2005;113:1100-7. https://doi.org/10.1289/ehp.7615
  12. Kim EK, Lee SH. Comparison of obesity and growth development in menarcheal and nonmenarcheal girls. J Korean Diet Assoc 2003;9:106-13.
  13. Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics 2002;110:903-10. https://doi.org/10.1542/peds.110.5.903
  14. Korea Center for Disease Control and Prevention; Korean Pediatric Society, Committee for the Development of Growth Standard for Korean Children and Adolescents. 2007 Korean children and adolescents growth standard: commentary for the development of 2007 growth chart [Internet]. Cheongwon: KCDC, Division of Chronic Disease Surveillance; c2012 [cited 2012 Jun 10]. Available from: http://www. cdc.go.kr/CDC/info/CdcKrInfo0201.jsp?menuIds=HOME001-MNU0004-MNU0007-MNU0025&fid=28&q_type=&q_value= &cid=1235&pageNum=74.
  15. Lee SY, Kim YN, Kang YJ, Jang MJ, Kim J, Moon JS, et al. The methodology for developing the 2007 Korean growth charts and blood pressure nomogram in Korean children and adolescents. Korean J Pediatr 2008;51:26-32. https://doi.org/10.3345/kjp.2008.51.1.26
  16. Mogensen SS, Aksglaede L, Mouritsen A, Sorensen K, Main KM, Gideon P, et al. Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty. J Clin Endocrinol Metab 2011;96:1393-401. https://doi.org/10.1210/jc.2010-2745
  17. Lazar L, Kauli R, Pertzelan A, Phillip M. Gonadotropin-suppressive therapy in girls with early and fast puberty affects the pace of puberty but not total pubertal growth or final height. J Clin Endocrinol Metab 2002;87:2090-4. https://doi.org/10.1210/jc.87.5.2090
  18. Kaplowitz P. Clinical characteristics of 104 children referred for evaluation of precocious puberty. J Clin Endocrinol Metab 2004;89:3644-50. https://doi.org/10.1210/jc.2003-031532
  19. Kim TH, Coe HJ, Kim S, Lee SW, Chae HW, Kim YS, et al. Clinical and endocrinologic characteristics of children referred for precocious puberty. J Korean Soc Pediatr Endocrinol 2007;12:119-26.
  20. Na JM, Lee YJ, Kim MS, Lee DY, Yeo CY, Kim CJ, et al. Causes of precocious puberty: multicenter study in Honam area. J Korean Soc Pediatr Endocrinol 2009;14:30-7.
  21. Wattigney WA, Srinivasan SR, Chen W, Greenlund KJ, Berenson GS. Secular trend of earlier onset of menarche with increasing obesity in black and white girls: the Bogalusa Heart Study. Ethn Dis 1999;9:181-9.
  22. Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. Relation of age at menarche to race, time period, and anthropometric dimensions: the Bogalusa Heart Study. Pediatrics 2002; 110:e43. https://doi.org/10.1542/peds.110.4.e43
  23. Ribeiro J, Santos P, Duarte J, Mota J. Association between overweight and early sexual maturation in Portuguese boys and girls. Ann Hum Biol 2006;33:55-63. https://doi.org/10.1080/00207390500434135
  24. Demerath EW, Towne B, Chumlea WC, Sun SS, Czerwinski SA, Remsberg KE, et al. Recent decline in age at menarche: the Fels Longitudinal Study. Am J Hum Biol 2004;16:453-7. https://doi.org/10.1002/ajhb.20039
  25. Kaminski BA, Palmert MR. Genetic control of pubertal timing. Curr Opin Pediatr 2008;20:458-64. https://doi.org/10.1097/MOP.0b013e3283060ed4
  26. Shalitin S, Phillip M. Role of obesity and leptin in the pubertal process and pubertal growth: a review. Int J Obes Relat Metab Disord 2003; 27:869-74. https://doi.org/10.1038/sj.ijo.0802328
  27. Anderson SE, Dallal GE, Must A. Relative weight and race influence average age at menarche: results from two nationally representative surveys of US girls studied 25 years apart. Pediatrics 2003;111(4 Pt 1):844-50. https://doi.org/10.1542/peds.111.4.844
  28. Kaplowitz PB, Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME. Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics 2001;108:347-53. https://doi.org/10.1542/peds.108.2.347
  29. de Muinich Keizer SM, Mul D. Trends in pubertal development in Europe. Hum Reprod Update 2001;7:287-91. https://doi.org/10.1093/humupd/7.3.287
  30. Rosenfield RL, Lipton RB, Drum ML. Thelarche, pubarche, and menarche attainment in children with normal and elevated body mass index. Pediatrics 2009;123:84-8. https://doi.org/10.1542/peds.2008-0146
  31. Korean Statistical Information Service. Statistical database of Korean population census in 2010 [Internet]. Daejeon: Statistics Korea; c2010 [cited 2012 Jun 10]. Available from: http://kosis.kr/eng/database/ database_001000.jsp?listid=A&subtitle=Population/Household.

피인용 문헌

  1. Short-term neonatal/prepubertal exposure of dibutyl phthalate (DBP) advanced pubertal timing and affected hypothalamic kisspeptin/GPR54 expression differently in female rats vol.314, pp.1, 2013, https://doi.org/10.1016/j.tox.2013.09.007