한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제16권4호
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  • Pages.265-270
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  • 2012
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
권호 표지

Modulation of Neural Circuit Actvity by Ethanol in Basolateral Amygdala

  • Chung, Leeyup (Dept. of Pediatrics, Duke University School of Medicine)
  • 투고 : 2012.10.03
  • 심사 : 2012.11.27
  • 발행 : 2012.12.31
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초록

Ethanol actions in the amygdala formation may underlie in part the reinforcing effects of ethanol consumption. Previously a physiological phenomenon in the basolateral amygdala (BLA) that is dependent on neuronal network activity, compound postsynaptic potentials (cPSPs) were characterized. Effects of acute ethanol application on the frequency of cPSPs were subsequently investigated. Whole cell patch clamp recordings were performed from identified projection neurons in a rat brain slice preparation containing the amygdala formation. Acute ethanol exposure had complex effects on cPSP frequency, with both increases and decreases dependent on concentration, duration of exposure and age of the animal. Ethanol produces complex biphasic effects on synaptically-driven network activity in the BLA. These findings may relate to subjective effects of ethanol on arousal and anxiolysis in humans.

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참고문헌

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