Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
권호 표지
DOI QR코드

DOI QR Code

Oxidative Stress in Vivax Malaria

  • Bilgin, Ramazan (University of Cukurova, Arts & Science Faculty, Chemistry Department (Biochemistry Division)) ;
  • Yalcin, Mustafa S. (University of Cukurova, Arts & Science Faculty, Chemistry Department (Biochemistry Division)) ;
  • Yucebilgic, Guzide (University of Cukurova, Arts & Science Faculty, Chemistry Department (Biochemistry Division)) ;
  • Koltas, Ismail S. (University of Cukurova, Medicine Faculty, Parasitology Department) ;
  • Yazar, Suleyman (Erciyes University, Medicine Faculty, Parasitology Department)
  • Received : 2012.05.03
  • Accepted : 2012.07.25
  • Published : 2012.12.17
Download PDF
⟨ Previous Next ⟩

Abstract

Malaria is still a leading cause of morbidity and mortality. The increase in lipid peroxidation reported in malaria infection and antioxidant status may be a useful marker of oxidative stress during malaria infection. The aim of this study was to investigate the role of antioxidant enzymes against toxic reactive oxygen species in patients infected with Plasmodium vivax and healthy controls. Malondialdehyde levels, superoxide dismutase, and glutathione peroxidase activities were determined in 91 P. vivax patients and compared with 52 controls. Malondialdehyde levels, superoxide dismutase, and glutathione peroxidase activities were $8.07{\pm}2.29$ nM/ml, $2.69{\pm}0.33$ U/ml, and $49.6{\pm}3.2$ U/g Hb in the patient group and $2.72{\pm}0.50$ nM/ml, $3.71{\pm}0.47$ U/ml, and $62.3{\pm}4.3$ U/g Hb in the control group, respectively. Malondialdehyde levels were found statistically significant in patients with vivax malaria higher than in healthy controls (P<0.001). On the other hand, superoxide dismutase and glutathione peroxidase activities were found to be significantly lower in vivax malaria patients than in controls (P<0.05). There was an increase in oxidative stress in vivax malaria. The results suggested that antioxidant defense mechanisms may play an important role in the pathogenesis of P. vivax.

Keywords

References

  1. Li J, Collins WE, Wirtz RA, Rathore D, Lal A, McCutchan TF. Geographic subdivision of the range of the malaria parasite Plasmodium vivax. Emerg Infect Dis 2001; 7: 35-42. https://doi.org/10.3201/eid0701.010105
  2. World Health Organization. WHO Expert Committee on Malaria: Twentieth report, WHO Technical Report Series, No. 892. Geneva, Switzerland. WHO. 1998, p 3-18.
  3. World Health Organization. New Perspectives, Malaria Diagnosis. Geneva, Switzerland. WHO. 2000, p 5-40.
  4. Akdur R. Sıtma Temel Bilgiler. Ankara, Turkiye. Palme Yayincilik. 2004, p 1-21.
  5. Becker K, Tilley L, Vennerstrom JL, Roberts D, Rogerson S, Ginsburg H. Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions. Int J Parasitol 2004; 34: 163-189. https://doi.org/10.1016/j.ijpara.2003.09.011
  6. Schwartz E, Samuni A, Friedman I, Hempelmann E, Golenser J. The role of superoxide dismutation in malaria parasites. Inflammation 1999; 23: 361-370.
  7. Mishra NC, Kabilan L, Sharma A. Oxidative stress and malaria-infected erythrocytes. Indian J Malariol 1994; 31: 77-87.
  8. Sarin K, Kumar A, Prakash A, Sharma A. Oxidative stress and antioxidant defence mechanism in Plasmodium vivax malaria before and after chloroquine treatment. Indian J Malariol 1993; 30: 127-133.
  9. Draper HH, Hadley M. A review of recent studies on the metabolism of exogenous and endogenous malondialdehyde. Xenobiotica 1990; 20: 901-907. https://doi.org/10.3109/00498259009046905
  10. Nayak DU, Karmen C, Frishman WH, Vakili BA. Antioxidant vitamins and enzymatic and synthetic oxygen-derived free radical scavengers in the prevention and treatment of cardiovascular disease. Heart Dis 2001; 3: 28-45.
  11. Romero FJ, Bosch-Morell F, Romero MJ, Jareno EJ, Romero B, Marin N, Roma J. Lipid peroxidation products and antioxidants in human disease. Environ Health Perspect 1998; 106: 1229-1234. https://doi.org/10.1289/ehp.98106s51229
  12. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-358. https://doi.org/10.1016/0003-2697(79)90738-3
  13. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34: 497-500.
  14. Beutler E. Red Cell Metabolism: A Manual of Biochemical Methods. 2nd ed. New York, USA. Grune and Starton. 1975, p 74-76.
  15. Descamps-Latscha B, Lunel-Fabiani F, Kara-binis A, Druilhe P. Generation of reactive oxygen species in whole blood from patients with acute falciparum malaria. Parasite Immunol 1987; 9: 275-279. https://doi.org/10.1111/j.1365-3024.1987.tb00507.x
  16. Kaikai P, Thurnham DI. The influence of riboflavin deficiency on Plasmodium berghei infection in rats. Trans R Soc Trop Med Hyg 1983; 77: 680-686. https://doi.org/10.1016/0035-9203(83)90204-3
  17. Thurnham DI, Oppenheimer SJ, Bull R. Riboflavin status and malaria in infants in Papua New Guinea. Trans R Soc Trop Med Hyg 1983; 77: 423-424. https://doi.org/10.1016/0035-9203(83)90180-3
  18. Erel O, Kocyigit A, Avcı S, Aktepe N, Bulut V. Oxidative stress and antioxidative status of plasma and erythrocytes in patients with vivax malaria. Clin Biochem 1997; 30: 631-639. https://doi.org/10.1016/S0009-9120(97)00119-7
  19. Blum J, Fridovich I. Inactivation of glutathione peroxidase by superoxide radical. Arch Biochem Biophys 1985; 240: 500-508. https://doi.org/10.1016/0003-9861(85)90056-6
  20. Jacob HS, Jandl JH. Effects of sulfhydryl inhibition on red blood cells. 3. Glutathione in the regulation of the hexose monophosphate pathway. J Biol Chem 1966; 241: 4243-4250.
  21. Bhattacharya J, Swarup-Mitra S. Reduction in erythrocytic GSH level and stability in Plasmodium vivax malaria. Trans R Soc Trop Med Hyg 1987; 81: 64-66. https://doi.org/10.1016/0035-9203(87)90285-9
  22. Das BS, Nanda NK. Evidence for erythrocyte lipid peroxidation in acute falciparum malaria. Trans R Soc Trop Med Hyg 1999; 93: 58-62. https://doi.org/10.1016/S0035-9203(99)90180-3
  23. Yazar S, Kilic E, Saraymen R, Ozbilge H. Serum malondialdehyde levels in patients infected with Plasmodium vivax. West Indian Med J 2004; 53: 147-149.
  24. Pabón A, Carmona J, Burgos LC, Blair S. Oxidative stress in patients with non-complicated malaria. Clin Biochem 2003; 36: 71-78. https://doi.org/10.1016/S0009-9120(02)00423-X
  25. Hamel CT, Blum J, Harder F, Kocher T. Nonoperative treatment of splenic rupture in malaria tropica: review of literature and case report. Acta Trop 2002; 82: 1-5. https://doi.org/10.1016/S0001-706X(02)00025-6

Cited by

  1. Role of oxidative stress in infectious diseases. A review vol.58, pp.6, 2013, https://doi.org/10.1007/s12223-013-0239-5
  2. Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria vol.10, pp.4, 2012, https://doi.org/10.1371/journal.ppat.1004038
  3. Protective Effect of Aqueous Crude Extract of Neem ( Azadirachta indica ) Leaves on Plasmodium berghei -Induced Renal Damage in Mice vol.2015, pp.None, 2012, https://doi.org/10.1155/2015/961205
  4. Host genetic variations in glutathione-S-transferases, superoxide dismutases and catalase genes influence susceptibility to malaria infection in an Indian population vol.290, pp.3, 2015, https://doi.org/10.1007/s00438-014-0984-4
  5. Plasma glutathione and oxidized glutathione level, glutathione/oxidized glutathione ratio, and albumin concentration in complicated and uncomplicated falciparum malaria vol.6, pp.8, 2016, https://doi.org/10.1016/j.apjtb.2016.06.003
  6. Anti-erythrocyte antibodies may contribute to anaemia in Plasmodium vivax malaria by decreasing red blood cell deformability and increasing erythrophagocytosis vol.15, pp.None, 2012, https://doi.org/10.1186/s12936-016-1449-5
  7. Asymptomatic Intestinal Colonization with Protist Blastocystis Is Strongly Associated with Distinct Microbiome Ecological Patterns vol.3, pp.3, 2018, https://doi.org/10.1128/msystems.00007-18
  8. Anti-band 3 and anti-spectrin antibodies are increased in Plasmodium vivax infection and are associated with anemia vol.8, pp.None, 2018, https://doi.org/10.1038/s41598-018-27109-6
  9. Decreased uric acid levels in the acute phase of Plasmodium vivax malaria vol.52, pp.None, 2012, https://doi.org/10.1590/0037-8682-0412-2017
  10. Oxidative Stress and Pathogenesis in Malaria vol.11, pp.None, 2021, https://doi.org/10.3389/fcimb.2021.768182
  11. Reactive Oxygen Species as the Brainbox in Malaria Treatment vol.10, pp.12, 2012, https://doi.org/10.3390/antiox10121872