Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
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Prioritizing Management Ranking for Hazardous Chemicals Reflecting Aggregate Exposure

통합노출을 고려한 유해물질 관리의 우선순위 선정

  • Jeong, Ji-Yoon (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Jung, Yoo-Kyung (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Hwang, Myung-Sil (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Jung, Ki-Kyung (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Yoon, Hae-Jung (Risk Analysis & Research Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex)
  • 정지윤 (식품의약품안전청 식품의약품안전평가원 식품위해평가부 위해분석연구과) ;
  • 정유경 (식품의약품안전청 식품의약품안전평가원 식품위해평가부 위해분석연구과) ;
  • 황명실 (식품의약품안전청 식품의약품안전평가원 식품위해평가부 위해분석연구과) ;
  • 정기경 (식품의약품안전청 식품의약품안전평가원 식품위해평가부 위해분석연구과) ;
  • 윤혜정 (식품의약품안전청 식품의약품안전평가원 식품위해평가부 위해분석연구과)
  • Received : 2012.02.22
  • Accepted : 2012.09.18
  • Published : 2012.12.31
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Abstract

In this study, we configured a system which ranks hazardous chemicals to determine their management priorities based on experts' opinions and the existing CRS (chemical ranking and scoring). Aggregate exposure of food, health functional food, oriental/herbal medicine and cosmetics have been taken into account to determine management priority. In this study, 25 hazardous chemicals were selected, such as cadmium, lead, mercury, and arsenic, etc. These 25 materials were ranked according to their 1) risk (exposure or hazard) indexes, 2) exposure source-based weight, and 3) public interests, which were also formed based on the existing priority ranking system. Cadmium was scored the highest (178.5) and bisphenol A the lowest (56.8). Ten materials -- cadmium, lead, mercury, arsenic, tar, acrylamide, benzopyrene, aluminium, benzene, and PAHs -- scored higher than 100. Eight materials -- aflatoxin, manganese, phthalate, chromium, nitrate/nitrite, ethylcarbamate, formaldehyde, and copper -- recorded scores in the range from 70 to 100. Also evaluated as potential risks were 7 materials; sulfur dioxide, ochratoxin, dioxins, PCBs, fumonisin, methyl mercury, and bisphenol A, and these materials were scored above 50. Then we compared risk index and correlation coefficient of total scores to confirm the validity of the total scores; we analyzed correlation coefficient of parameter and indicator. We discovered that the total score and weight, which has incorporated public interests, were high and statistically significant. In conclusion, the result of this study contributes to strengthening risk assessment and risk management of hazardous chemicals.

통합노출을 고려한 식품, 건강기능식품, 생약/한약제제, 화장품에서의 유해물질 관리의 우선순위를 선정하기 위해 기존 CRS에서 활용한 위해크기 뿐만 아니라 사회적 인식도를 조사한 후 전문가 평가를 통해 합의된 결과를 점수화하는 우선순위 선정 시스템을 구성하였다. 본 연구에서는 카드뮴, 납, 수은 및 비소 등 25종의 유해물질을 선별하고 선정된 25개 물질에 대해 기존의 우선순위 선정 시스템을 토대로 대상물질별 1) 위해의 크기 (노출 또는 위해수준), 2) 노출원을 고려한 가중치, 3) 관심도의 3가지면에 대해 점수를 산출하였다. 그 결과 25개 물질 중 최종점수는 카드뮴이 178.5점으로 가장 높았으며, 비스페놀 A가 56.8점으로 가장 낮았다. 최종점수가 100점 이상인 물질은 카드뮴, 납, 수은, 비소, 타르, 아크릴아마이드, 벤조피렌, 알루미늄, 벤젠 및 PAHs의 10종이었으며, 아플라톡신, 망간, 프탈레이트, 크롬, 아질산염, 에틸카바메이트, 포름알데히드 및 구리의 8종 물질은 70점 이상이었다. 그 외 이산화황, 오크라톡신 등 7종의 물질이 50점 이상으로 평가되었다. 평가된 최종점수의 타당성 평가를 위해 변수 간의 관련성과 지표간의 상관성분석을 분석한 결과, 노출원에 가중치를 고려한 위해크기가 가중치를 고려하지 않은 위해크기에 비해 최종점수와 관심도 모두 상관성이 높게 나타났으며, 통계적으로 매우 유의한 것으로 나타났다. 이처럼 통합노출을 고려한 유해물질 관리의 우선순위 연구는 위해평가 및 위해관리 측면에서 활용 가능 할 것으로 판단되어 진다.

Keywords

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