The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Idiopathic Granulomatous Hypophysitis

  • Chung, Chul-Ho (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Song, Min-Soo (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Cho, Hyun-Deuk (Department of Pathology, Soonchunhyang University College of Medicine) ;
  • Jeong, Du-Shin (Department of Neurology, Soonchunhyang University College of Medicine) ;
  • Kim, Yeo-Joo (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Bae, Hack-Gun (Department of Neurosurgery, Soonchunhyang University College of Medicine) ;
  • Kim, Sang-Jin (Department of Internal Medicine, Soonchunhyang University College of Medicine)
  • Published : 2012.09.01
⟨ Previous Next ⟩

Abstract

Granulomatous hypophysitis is a rare pituitary condition that commonly presents with enlargement of the pituitary gland. A 31-year-old woman was admitted to the hospital with a severe headache and bitemporal hemianopsia. Magnetic resonance imaging (MRI) showed an 18 ${\times}$ 10-mm sellar mass with suprasellar extension and compression of the optic chiasm. Interestingly, brain MRI had shown no abnormal finding 4 months previously. On hormonal examination, hypopituitarism with mild hyperprolactinemia was noted. The biopsy revealed granulomatous changes with multinucleated giant cells. We herein report this rare case and discuss the relevant literature.

Keywords

References

  1. Cheung CC, Ezzat S, Smyth HS, Asa SL. The spectrum and significance of primary hypophysitis. J Clin Endocrinol Metab 2001;86:1048-1053. https://doi.org/10.1210/jc.86.3.1048
  2. Stott V, Manning P, Hung N. Idiopathic granulomatous hypophysitis. N Z Med J 2005;118:U1355.
  3. Vasile M, Marsot-Dupuch K, Kujas M, et al. Idiopathic granulomatous hypophysitis: clinical and imaging features. Neuroradiology 1997;39:7-11. https://doi.org/10.1007/s002340050357
  4. Lee CI, Chung YG, Kim SD, Lee HK. Idiopathic granulomatous hypophysitis. J Korean Neurosurg Soc 2003;34:386-388.
  5. Honegger J, Fahlbusch R, Bornemann A, et al. Lymphocytic and granulomatous hypophysitis: experience with nine cases. Neurosurgery 1997;40:713-722. https://doi.org/10.1097/00006123-199704000-00010
  6. Caturegli P, Newschaffer C, Olivi A, Pomper MG, Burger PC, Rose NR. Autoimmune hypophysitis. Endocr Rev 2005;26:599-614. https://doi.org/10.1210/er.2004-0011
  7. Mehndiratta MM, Phul P, Singh AK, Garg S, Bali R. Granulomatous hypophysitis: an interesting and rare cause mimicking pituitary mass. J Assoc Physicians India 2007;55:653-654.
  8. Brisman MH, Morgello S, Silvers A, Klein I, Post KD. Idiopathic granulomatous hypophysitis. Neurosurg Focus 1996;1:e7.

Cited by

  1. Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature vol.17, pp.4, 2012, https://doi.org/10.1007/s11102-013-0510-4
  2. Idiopathic Granulomatous Hypophysitis: A Rare Cystic Lesion of the Pituitary vol.54, pp.11, 2015, https://doi.org/10.2169/internalmedicine.54.3342
  3. Primary Granulomatous Hypophysitis Presenting with Panhypopituitarism and Central Diabetes Insipidus vol.88, pp.5, 2015, https://doi.org/10.3904/kjm.2015.88.5.581
  4. Idiopathic Granulomatous Hypophysitis Mimicking Pituitary Abscess vol.94, pp.28, 2015, https://doi.org/10.1097/md.0000000000001099
  5. Granulomatous hypophysitis: rare disease with challenging diagnosis vol.5, pp.7, 2017, https://doi.org/10.1002/ccr3.1007
  6. Idiopathic granulomatous hypophysitis: A report of an uncommon disorder vol.61, pp.3, 2012, https://doi.org/10.4103/ijpm.ijpm_77_17
  7. PRIMARY GRANULOMATOUS HYPOPHYSITIS PRESENTING WITH SECONDARY HYPOTHYROIDISM vol.4, pp.4, 2012, https://doi.org/10.4158/accr-2017-0121
  8. Hypophysitis (Including IgG4 and Immunotherapy) vol.110, pp.9, 2012, https://doi.org/10.1159/000506903