The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Role of Photodynamic Therapy in the Palliation of Obstructing Esophageal Cancer

  • Yoon, Hyeon-Young (Digestive Disease Center, Department of Internal Medicine, Konkuk University School of Medicine) ;
  • Cheon, Young-Koog (Digestive Disease Center, Department of Internal Medicine, Konkuk University School of Medicine) ;
  • Choi, Hye-Jin (Digestive Disease Center, Department of Internal Medicine, Konkuk University School of Medicine) ;
  • Shim, Chan-Sup (Digestive Disease Center, Department of Internal Medicine, Konkuk University School of Medicine)
  • Published : 2012.09.01
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Abstract

Background/Aims: The aim of this non-randomized study was to determine the role of photodynamic therapy (PDT) in a multimodal approach for the palliation of advanced esophageal carcinoma. Methods: Twenty consecutive patients with obstructing esophageal cancer were enrolled in this study. Each subject had dysphagia, and nine could not swallow fluid. External beam radiotherapy or a self-expandable metal stent was used following PDT for dysphagia due to recurrence of the malignancy. Results: At 4 weeks post-PDT, a significant improvement in the dysphagia score was observed in 90% of patients, from 2.75 ${\pm}$ 0.91 to 1.05 ${\pm}$ 0.83 (p < 0.05). Patients with recurrent dysphagia underwent stent insertion at an average of 63 days (range, 37 to 90). The rate of major complications was 10%. Two esophageal strictures occurred, which were treated by placement of a modified expandable stent across the stricture. The median survival in these cases was 7.0 ${\pm}$ 0.6 months. One patient that was treated with PDT and radiotherapy is alive and showed a complete tumor response. Conclusions: PDT as a multimodality treatment is safe and effective for relieving malignant esophageal obstruction with minimal complications.

Keywords

References

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